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(S)-(-)-2-(Boc-Amino)-1,4-butanediol

Product Name
(S)-(-)-2-(Boc-Amino)-1,4-butanediol
CAS No.
128427-10-1
Chemical Name
(S)-(-)-2-(Boc-Amino)-1,4-butanediol
Synonyms
(S)-2-Boc-amino-butane-1,4-diol;(S)-2-N-Boc-aMinobutane-1,4-diol;(S)-N-BOC-2-AMINO-BUTANE-1,4-DIOL;(S)-(-)-2-(boc-Amino)-1,4-butendiol;(S)-(-)-N-Boc-2-Amino-1,4-butanediol;(S)-(-)-2-(Boc-Amino)-1,4-butanediol;(S)-N-BOC-2-AMINO-BUTANE-1,4-DIOL ,97%;tert-butyl N-(4,4-dihydroxybutyl)carbaMate;(S)-(?)-2-(Boc-amino)-1,4-butanediol;tert-butyl(S)-1,4-dihydroxybutan-2-ylcarbamate
CBNumber
CB7504648
Molecular Formula
C9H19NO4
Formula Weight
205.25
MOL File
128427-10-1.mol
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(S)-(-)-2-(Boc-Amino)-1,4-butanediol Property

Melting point:
65-69 °C(lit.)
alpha 
-8 º (c=1 in chloroform)
Boiling point:
365.0±32.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
2-8°C
form 
Crystalline Powder
pka
11.81±0.46(Predicted)
color 
White
optical activity
[α]20/D 8°, c = 1 in chloroform
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Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29051990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
536652
Product name
(S)-(?)-2-(Boc-amino)-1,4-butanediol
Purity
97%
Packaging
5g
Price
$283
Updated
2025/07/31
Sigma-Aldrich
Product number
536652
Product name
(S)-(?)-2-(Boc-amino)-1,4-butanediol
Purity
97%
Packaging
1g
Price
$91
Updated
2023/06/20
TRC
Product number
B630043
Product name
(S)-(-)-2-(BOC-Amino)-1,4-butanediol
Packaging
50mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB151964
Product name
(S)-(-)-2-(Boc-amino)-1,4-butanediol
Packaging
5G
Price
$225
Updated
2021/12/16
AK Scientific
Product number
X7005
Product name
(S)-(-)-2-(Boc-Amino)-1,4-butanediol
Packaging
5g
Price
$242
Updated
2021/12/16
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(S)-(-)-2-(Boc-Amino)-1,4-butanediol Chemical Properties,Usage,Production

Chemical Properties

whitecrystallinepowde

Uses

(S)-(?)-2-(Boc-amino)-1,4-butanediol can be used as a reactant to synthesize:

  • Thiourea-based organocatalysts for asymmetric Michael addition reactions of nitroalkenes to α-nitrocyclohexanone.
  • Bis-copper (II) complex based catalysts for enantioselective Michael reactions.

Synthesis

130622-08-1

128427-10-1

B. Add lithium aluminum hydride (0.870 g, 22.9 mmol) to a pre-oven-dried round-bottomed flask under a dry nitrogen atmosphere. The flask was cooled to 0°C in an ice bath, followed by the addition of 100 mL of anhydrous ether. In another dry round-bottomed flask, compound 2 (2.021 g, 7.735 mmol) was dissolved in 50 mL of anhydrous ether, sonicated if necessary to ensure complete dissolution. This ester solution was slowly added dropwise to the reaction mixture. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 0°C for 30 minutes, then warmed to room temperature and reacted for 2 hours. Upon completion of the reaction, 0.87 mL of water, 0.87 mL of 15% w/w NaOH solution and 2.6 mL of water were added slowly and sequentially at 0°C to quench the reaction. The mixture was stirred at room temperature for 1 hour. The aluminum salt was collected by vacuum filtration and subjected to sequential solid-liquid extraction with dichloromethane using a Soxhlet extractor. The organic extract was combined with the original organic filtrate and concentrated under reduced pressure. Purification by fast chromatography (eluent: ethyl acetate) afforded (S)-tert-butyl-1,4-dihydroxybutan-2-ylcarbamate (3) (1.310 g, 82% yield) in white solid form. Compound 3 was prepared from L-aspartic acid by a different route. [00161] 1H NMR (400 MHz, DMSO-d6) δ = 6.46 (d, J = 8.8 Hz, 1H), 4.56 (t, J = 5.7 Hz, 1H), 4.34 (t, J = 5.1 Hz, 1H), 3.46-3.37 (m, 3H), 3.32 (dt, J = 10.6, 5.4 Hz, 1H) 3.23 (dt, J = 10.6, 5.9 Hz, 1H), 1.69-1.61 (m, 1H), 1.45-1.37 (m, 1H), 1.37 (s, 9H); 13C NMR (75 MHz, CDCl3) δ = 157.2, 80.1, 65.4, 58.9, 49.5, 35.0, 28.5; HRMS ( ESI) calculated value [C9H19NO4Na]+ (M + Na+) m/z = 228.1207, measured value 228.1201.

References

[1] Synthesis, 2010, # 2, p. 293 - 303
[2] Journal of the American Chemical Society, 2012, vol. 134, # 9, p. 4057 - 4059
[3] Patent: WO2013/123382, 2013, A1. Location in patent: Paragraph 00160; 00161
[4] Heterocycles, 1997, vol. 44, # 1, p. 213 - 225
[5] Synthetic Communications, 1998, vol. 28, # 21, p. 3919 - 3926

(S)-(-)-2-(Boc-Amino)-1,4-butanediol Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-(-)-2-(Boc-Amino)-1,4-butanediol Suppliers

China 123 Europe 1 Germany 3 India 5 Switzerland 1 United Kingdom 3 United States 21 Global 157
Shanghai Fengluan Biotechnology Co., LTD
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View Lastest Price from (S)-(-)-2-(Boc-Amino)-1,4-butanediol manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd
Product
(S)-(-)-2-(Boc-Amino)-1,4-Butanediol 128427-10-1
Price
US $100.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
98%
Supply Ability
10KG
Release date
2021-09-14
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
(s)-(-)-2-(Boc-amino) -1,4-Butanediol 128427-10-1
Price
US $100.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
10kg
Release date
2021-09-15
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
(s)-(-)-2-(Boc-amino) -1,4-Butanediol 128427-10-1
Price
US $100.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2021-09-17

128427-10-1, (S)-(-)-2-(Boc-Amino)-1,4-butanediolRelated Search:

BUTYL OLEATE tert-Butyl acetate (S)-(+)-2-Amino-1-butanol Buprofezin Butylparaben ALTRENOGEST tert-Butyl carbazate CHLOROPHOSPHONAZO III Methylparaben 4-Dimethylaminopyridine Tris(trimethylsilyl)phosphate 6-Aminocaproic acid Cyhalofop-butyl Butyl acetate tert-Butyl carbamate 4-Hydroxybenzoic acid Acetaminophen Tris(hydroxymethyl)aminomethane

  • tert-butyl N-(1,4-dihydroxybutan-2-yl)carbaMate
  • (S)-2-N-Boc-aMinobutane-1,4-diol
  • tert-butyl N-(4,4-dihydroxybutyl)carbaMate
  • tert-butyl(S)-1,4-dihydroxybutan-2-ylcarbamate
  • Carbamic acid, N-[(1S)-3-hydroxy-1-(hydroxymethyl)propyl]-, 1,1-dimethylethyl ester
  • tert-butyl N-[(2S)-1,4-dihydroxybutan-2-yl]carbamate
  • (S)-(-)-N-Boc-2-Amino-1,4-butanediol
  • Carbamic acid, [(1S)-3-hydroxy-1-(hydroxymethyl)propyl]-, 1,1-dimethylethyl
  • (S)-(-)-2-(boc-Amino)-1,4-butendiol
  • (S)-N-BOC-2-AMINO-BUTANE-1,4-DIOL
  • (S)-TERT-BUTYL 1,4-DIHYDROXYBUTAN-2-YLCARBAMATE
  • (S)-N-BOC-2-AMINO-BUTANE-1,4-DIOL ,97%
  • (S)-(-)-2-(Boc-Amino)-1,4-butanediol
  • (S)-(3-Hydroxy-1-hydroxymethylpropyl)carbamic acid tert-butyl ester
  • (S)-2-Boc-amino-butane-1,4-diol
  • (S)-2-(((neopentyloxy)carbonyl)amino)succinic acid
  • (S)-(-)-2-(Boc-Amino)-1,4-butanediol USP/EP/BP
  • (<i>S</i>)-(?)-2-(Boc-amino)-1,4-butanediol
  • 128427-10-1
  • HOCH2CH2CHNHCO2CCH33CH2OH
  • N-BOC
  • API intermediates
  • Chiral Compounds
  • Amino Alcohols
  • Chiral Building Blocks
  • Organic Building Blocks