XCT 790
- Product Name
- XCT 790
- CAS No.
- 725247-18-7
- Chemical Name
- XCT 790
- Synonyms
- CS-1881;XCT 790; XCT-790;XCT 790,Inhibitor,Estrogen Receptor/ERR,Autophagy,XCT790,inhibit,XCT-790;3-[4-(2,4-bis-trifluoromethylbenzyloxy)-3-methoxyphenyl]-2-cyano-n-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)acrylamide;2-Propenamide, 3-[4-[[2,4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-;(E)-3-[4-[[2,4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]prop-2-enamide;3-[4-[[2,4-Bis(trifluoromethyl)benzyl]oxy]-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-[1,3,4]thiadiazol-2-yl)acrylamide XCT 790;XCT 790 3-[4-[[2,4-Bis(trifluoromethyl)benzyl]oxy]-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-[1,3,4]thiadiazol-2-yl)acrylamide
- CBNumber
- CB7505302
- Molecular Formula
- C23H13F9N4O3S
- Formula Weight
- 596.42
- MOL File
- 725247-18-7.mol
XCT 790 Property
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥10mg/mL
- form
- solid
- color
- yellow
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
N-Bromosuccinimide Price
- Product number
- X4753
- Product name
- XCT790
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $223
- Updated
- 2024/03/01
- Product number
- X4753
- Product name
- XCT790
- Purity
- ≥98% (HPLC), solid
- Packaging
- 25mg
- Price
- $513.6
- Updated
- 2024/03/01
- Product number
- 16035
- Product name
- XCT790
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 16035
- Product name
- XCT790
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $131
- Updated
- 2024/03/01
- Product number
- 16035
- Product name
- XCT790
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $213
- Updated
- 2024/03/01
XCT 790 Chemical Properties,Usage,Production
Description
XCT790 is an inverse agonist of estrogen-related receptor α (ERRα; IC50 = ~300-500 nM). It demonstrates 90-100% inhibition of ERRα constitutive activity and has no significant activity at related nuclear receptors at 10 μM. XCT790 associates with the ligand-binding domain of ERRα and blocks ERRα/PGC-1α-dependent signaling, suppressing the expression of monoamine oxidases A and B. XCT790 induces proteasomal degradation of ERRα and potentiates the degradation of the estrogen receptor ERα by fulvestrant .
Uses
XCT790 is a potent inverse agonist of ERRα.
Definition
ChEBI: XCT 790 is a member of cinnamamides.
Biochem/physiol Actions
XCT 790 is a 5′adenosine monophosphate-activated protein kinase (AMPK) activator. It also acts as a proton ionophore and an uncoupler of oxidative phosphorylation in mitochondria. XCT790 impairs vascular endothelial growth factor (VEGF) and angiopoietin 2 (Ang-2) expression and exhibits suppression of endometrial tumor via estrogen-related receptor (ERRα) inhibition. XCT790 mediates cell cycle arrest and favors apoptosis in triple-negative breast cancer (TNBC).
storage
Store at +4°C
References
[1] lu x, peng l, lv m, ding k. recent advance in the design of small molecular modulators of estrogen-related receptors. curr pharm des. 2012;18(23):3421-31.
[2] wu f, wang j, wang y, kwok tt, kong sk, wong c. estrogen-related receptor alpha (erralpha) inverse agonist xct-790 induces cell death in chemotherapeutic resistant cancer cells. chem biol interact. 2009 oct 7;181(2):236-42.
XCT 790 Preparation Products And Raw materials
Raw materials
Preparation Products
XCT 790 Suppliers
- Tel
- --
- Fax
- --
- info@axonmedchem.com
- Country
- The Netherlands
- ProdList
- 477
- Advantage
- 30
View Lastest Price from XCT 790 manufacturers
- Product
- XCT 790 725247-18-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%HPLC
- Supply Ability
- 100KG
- Release date
- 2020-02-04