ChemicalBook > CAS DataBase List > 42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin

42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin

Product Name
42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin
CAS No.
143030-02-8
Chemical Name
42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin
Synonyms
Rapamycin Impurity 32;42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin;Rapamycin, 42-O-[(1,1-dimethylethyl)dimethylsilyl]-;Clobetasone Butyrate Impurity 9 (Clobetasone Butyrate EP Impurity I)
CBNumber
CB75177306
Molecular Formula
C57H93NO13Si
Formula Weight
1028.45
MOL File
143030-02-8.mol
More
Less

42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin Property

Boiling point:
977.0±75.0 °C(Predicted)
Density 
1.12±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Dichloromethane, Methanol
form 
Solid
pka
10.40±0.70(Predicted)
color 
White
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

TRC
Product number
D479400
Product name
42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin
Packaging
25mg
Price
$735
Updated
2021/12/16
More
Less

42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin Chemical Properties,Usage,Production

Uses

42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin is an intermediate in the synthesis of 8-O-Methyl-rapamycin which is a derivative of Rapamycin (R124000), a triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic. Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants.

42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin Suppliers

China 7 United States 1 Global 8

143030-02-8, 42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycinRelated Search:

Everolimus 2-Piperidinecarboxylic acid, 1-[[(2R,3R,6S)-6-[(2S,3E,5E,7E,9S,11R)-2,13-dimethoxy-3,9,11-trimethyl-12-oxo-3,5,7-tridecatrienyl]tetrahydro-2-hydroxy-3-methyl-2H-pyran-2-yl]oxoacetyl]-, (1S,4R,5E)-1-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-4,6-dimethyl-3,7-dioxo-5-heptenyl es... Everolimus EP Impurity E USDOYNAPNXMXOE-SPSCNLKESA-N Everolimus Impurity 1 23,27-Epoxy(7E,15E,17E,19E)-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone, 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexam... Everolimus Related Compound 3 EveroliMus-d4 Everolimus Related Compound 2 Rapamycin, 32-O-demethyl- Seco Rapamycin Everolimus Hydrolized Impurity 28-epirapamycin Everolimus Ring-Opening Impurity 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone

  • 42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin
  • Rapamycin Impurity 32
  • Rapamycin, 42-O-[(1,1-dimethylethyl)dimethylsilyl]-
  • Clobetasone Butyrate Impurity 9 (Clobetasone Butyrate EP Impurity I)
  • 143030-02-8