ChemicalBook > CAS DataBase List > tert-Butyl 3-aminopyrrolidine-1-carboxylate

tert-Butyl 3-aminopyrrolidine-1-carboxylate

Product Name: tert-Butyl 3-aminopyrrolidine-1-carboxylate
CAS No.: 186550-13-0
Chemical Name: tert-Butyl 3-aminopyrrolidine-1-carboxylate
Synonyms: 1-BOC-3-AMINOPYRROLIDINE;CAS:186550-13-0;Methyl N-benzyl-3-;1-Boc-3-aminopyrro;3-AMINO-1-BOC-PYRROLIDINE;3-AMINO-1-N-BOC-PYRROLIDINE;1-N-BOC-3-AMINO-PYRROLIDINE;1-Boc-3-aminopyrrolidine 95%;1-Boc-3-aminopyrrolidine ,97%;DL-3-AMINO-1-N-BOC-PYRROLIDINE
CBNumber: CB7664832
Molecular Formula: C9H18N2O2
Formula Weight: 186.25
MOL File: 186550-13-0.mol

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tert-Butyl 3-aminopyrrolidine-1-carboxylate Property

Boiling point:: 257.4±33.0 °C(Predicted)
Density: 1.022
Flash point:: 91°C
refractive index: 1.4710
storage temp.: 2-8°C
pka: 9.55±0.20(Predicted)
form: powder to lump to clear liquid
color: White or Colorless to Light yellow
Sensitive: Air Sensitive
CAS DataBase Reference: 186550-13-0(CAS DataBase Reference)

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Safety

Hazard Codes: C,Xi,Xn
Risk Statements: 36/37/38-44-41-22
Safety Statements: 26-36/37/39
RIDADR: 2810
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 8
PackingGroup: Ⅲ
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 706582
Product name: 1-Boc-3-aminopyrrolidine
Purity: 95%
Packaging: 1g
Price: $55.4
Updated: 2025/07/31

TCI Chemical

Product number: B3890
Product name: 3-Amino-1-(tert-butoxycarbonyl)pyrrolidine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $85
Updated: 2025/07/31

TCI Chemical

Product number: B3890
Product name: 3-Amino-1-(tert-butoxycarbonyl)pyrrolidine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $338
Updated: 2025/07/31

TRC

Product number: T204658
Product name: Tert-butyl3-Aminopyrrolidine-1-carboxylate
Packaging: 1g
Price: $75
Updated: 2021/12/16

Usbiological

Product number: 263596
Product name: 1-Boc-3-aminopyrrolidine
Packaging: 1g
Price: $319
Updated: 2021/12/16

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tert-Butyl 3-aminopyrrolidine-1-carboxylate Chemical Properties,Usage,Production

Chemical Properties

Colorless low melting solid or liquid

Uses

1-Boc-3-Aminopyrrolidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Synthesis

862906-31-8

186550-13-0

Step (ii): preparation of tert-butyl 3-aminopyrrolidine-1-carboxylate (Formula 49) To a stirred solution of tert-butyl 3-hydroxypyrrolidine-1-carboxylate (Formula 48, 1.15 g, 4.16 mmol) in methanol (16.6 mL) was added 10% palladium/carbon catalyst (345 mg). The reaction mixture was stirred for 16 hours under a hydrogen atmosphere (hydrogen pressure applied via a double-layer balloon). Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad to remove the catalyst and the filtrate was concentrated under reduced pressure. The crude product was purified by silica gel fast column chromatography to afford the target compound tert-butyl 3-aminopyrrolidine-1-carboxylate (Formula 49, 640 mg) in 82% yield. 1H-NMR (CDCl3): δ 3.65-3.45 (m, 3H), 3.45-3.33 (m, 1H), 3.20-3.0 (m, 1H), 2.12-2.02 (m, 1H), 1.80-1.65 (m, 1H), 1.46 (s, 9H). Mass spectrum (m/z): 187 [M+H]+.

References

[1] Patent: WO2005/77924, 2005, A1. Location in patent: Page/Page column 76
[2] Patent: WO2011/30349, 2011, A1. Location in patent: Page/Page column 36-37

tert-Butyl 3-aminopyrrolidine-1-carboxylate Preparation Products And Raw materials

Raw materials

3-Aminopyrrolidine dihydrochloride Ethanol Di-tert-butyl dicarbonate Sodium Triethylamine Tosyl chloride Tetrahydrofuran 1-(tert-Butoxycarbonyl)-3-pyrrolidinol Dichloromethane Methanol Sodium hydroxide Isopropyl alcohol 1-Butanol Ammonia

Preparation Products

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View Lastest Price from tert-Butyl 3-aminopyrrolidine-1-carboxylate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 1-Boc-3-aminopyrrolidine 186550-13-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-22

Career Henan Chemical Co

Product: tert-Butyl 3-aminopyrrolidine-1-carboxylate 186550-13-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 500kg
Release date: 2018-08-17

186550-13-0, tert-Butyl 3-aminopyrrolidine-1-carboxylateRelated Search:

Crospovidone Butyl acetate Povidone iodine Dibutyl phthalate Cyhalofop-butyl 3-Aminopyrrolidine Diethylene glycol monobutyl ether BUTYL OLEATE Buprofezin RESMETHRIN Polyvinylpyrrolidone N-Methyl-2-pyrrolidone N-Vinyl-2-pyrrolidone tert-butyl 3-bromoazetidine-1-carboxylate METHYL-2-PYRROLIDONE N-Boc-cis-4-Fmoc-Amino-L-proline N-Boc-trans-4-amino-L-proline methyl ester hydrochloride (2S,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate hydrochloride

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3-Amino-1-(tert-butoxycarbonyl)pyrrolidine

Methyl N-benzyl-3-

tert-butyl 3-aminopyrrolidine-1-carboxylate(SALTDATA: FREE)

DL-3-Amino-1-N-Boc-Pyrrolidine 1-N-Boc-3-Aminopyrrolidine

1-Boc-3-aminopyrrolidine ,97%

(+/-)-3-AMINO-1-N-BOC-PYRROLIDINE-cictric acid salt

tert-Butyl 3-aminopyrrolidine-1-carboxylate, 3-Amino-1-(tert-butoxycarbonyl)pyrrolidine

(+/-)-3-AMINO-1-N-BOC-PYRROLIDINE-citrate

1-Boc-3-aminopyrrolidine 1-(tert-Butoxyarbonyl)-3-aminopyrrolidine 3-Amino-1-Boc-pyrrolidine

3-aMino-1-pyrrolidinecarboxylic acid,1,1-diMethylethyl ester

1-Pyrrolidinecarboxylic acid, 3-amino-, 1,1-dimethylethyl ester

(^+)-1-Boc-3-aminopyrrolidine,96%

3-amino-1-(t-butoxycarbonyl)pyrrolidine

1-Boc-3-aminopyrro

1-Boc-3-tert-Butyl3-aminopyrrolidine-1-carboxylate

3-Amino-1-(tert-butoxycarbonyl)pyrrolidine &gt

1-(tert-Butoxyarbonyl)-3-aminopyrrolidine

(+/-)-3-Amino-1-N-Boc-pyrrolidine

1,1-Dimethylethyl 3-amino-1-pyrrolidinecarboxylate

tert-Butyl3-aminipyrrolidine-1-carboxylate

CAS:186550-13-0

186550-13-0

pharmacetical

Amines

Pyrrolidines

Pyrrole&Pyrrolidine&Pyrroline