Glabridin

Product Name: Glabridin
CAS No.: 59870-68-7
Chemical Name: Glabridin
Synonyms: Q-100692;LGB-GD 90;LGB-GD 40;GLABRIDIN;KB-289522;LS-176045;Aids096010;glabridine;Aids-096010;Glabridin-RM
CBNumber: CB7670448
Molecular Formula: C20H20O4
Formula Weight: 324.37
MOL File: 59870-68-7.mol

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Glabridin Property

Melting point:: 154～155℃
Boiling point:: 518.6±50.0 °C(Predicted)
Density: 1.257±0.06 g/cm3(Predicted)
Flash point:: 267℃
storage temp.: room temp
solubility: DMSO: soluble5mg/mL, clear (warmed)
form: powder
pka: 9.66±0.40(Predicted)
color: white to light brown
BRN: 7141956
Stability:: Hygroscopic
InChI: InChI=1S/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1
InChIKey: PMPYOYXFIHXBJI-ZDUSSCGKSA-N
SMILES: C1(O)=CC=C([C@@H]2COC3=C4C=CC(C)(C)OC4=CC=C3C2)C(O)=C1
LogP: 4.260 (est)
CAS DataBase Reference: 59870-68-7(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G9548
Product name: Glabridin
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $129
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHL80463
Product name: Glabridin
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $584
Updated: 2024/03/01

Sigma-Aldrich

Product number: 53633
Product name: Glabridin
Purity: analytical standard
Packaging: 10mg
Price: $826
Updated: 2022/05/15

Cayman Chemical

Product number: 11843
Product name: Glabridin
Purity: ≥98%
Packaging: 5mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 11843
Product name: Glabridin
Purity: ≥98%
Packaging: 10mg
Price: $89
Updated: 2024/03/01

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Glabridin Chemical Properties,Usage,Production

Chemical Properties

White to tan powder, insoluble in water, easily soluble in organic solvents such as ethanol, propylene glycol, 1,3-butanediol, etc.

Uses

Glabridin is a compound extracted from Licorice (root) shows properties that are cytotoxic, antimicrobial, estrogenic and anti-proliferative.

Definition

ChEBI: Glabridin is a member of the class of hydroxyisoflavans that is (R)-isoflavan substituted by hydroxy groups at positions 2' and 4' and a 2,2-dimethyl-2H-pyran group across positions 7 and 8 respectively. It has a role as an antiplasmodial drug. It derives from a hydride of a (R)-isoflavan.

benefits

Glabridin has strong antibacterial effects and can prevent inflammation, pigmentation, and rough skin caused by ultraviolet rays. It can also remove superoxide ions and inhibit hemolysis caused by hydrogen peroxide. Moreover, it can inhibit the activity of tyrosinase and the conversion of dopachrome, making it an effective and environmentally-friendly additive for whitening and freckle removal in cosmetics. Additionally, Glabridin possesses similar abilities to scavenge oxygen free radicals as SOD (superoxide dismutase) and vitamin E, making it a powerful antioxidant.

Biochem/physiol Actions

Glabridin is a bio-available isoflavan isolated from licorice (Glycyrrhiza glabra L.) root extract. Glabridin has been reported to posses varies biological activities including strong antioxidant activity, antioxidant against LDL oxidation, anti-Helicobacter pylori properties, estrogen-like activity and antinephritic and radical scavenging activities. Also it appears to inhibit serotonin re-uptake, melanogenesis, inflammation and cytochrome P450 3A4, 2B6, and 2C9.

Mode of action

Glabridin[59870-68-7] is one of the main flavonoid components in Glycyrrhiza glabra. It shows a strong anti-free radical oxidation effect in the cytochrome P450/NADPH oxidation system, which can significantly inhibit the free radicals produced in the metabolic process of the body, to avoid oxidative damage to oxidation-sensitive biological macromolecules (low-density lipoprotein LDL, DNA) and the cell wall, etc. by free radical oxidation. Thus, it can prevent certain pathological changes related to free radical oxidation, such as atherosclerosis, and cellular aging. In addition, Glabridin has some hypolipidemic and hypotensive effects.

References

Glabridin, a functional compound of liquorice, attenuates colonic inflammation in mice with dextran sulphate sodium‐induced colitis DOI:10.1111/j.1365-2249.2007.03539.x
Structural insights into the binding behavior of isoflavonoid glabridin with human serum albumin DOI:10.1016/J.FOODHYD.2019.01.031
A novel ?uorescent recombinant cell-based biosensor for screening NLRP3 inflammasome inhibitors DOI:10.1016/j.snb.2019.126864
Glavonoid, a possible supplement for prevention of ATTR amyloidosis DOI:10.1016/j.heliyon.2021.e08101
Tian, M. et al.: Int. J. Mol. Sci., 9, 571 (2008); Simmler, C. et al.: Fitoterapia, 90, 160 (2013);

Glabridin Preparation Products And Raw materials

Raw materials

Preparation Products

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Glabridin Suppliers

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View Lastest Price from Glabridin manufacturers

Hangzhou Lin'an tianhong biotechnology co.,ltd.

Product: Glycyrrhiza glabra extract 90% -called "Whitening Gold". 59870-68-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 90%
Supply Ability: 100kgs
Release date: 2024-07-15

Hangzhou Lin'an tianhong biotechnology co.,ltd.

Product: Glabridin -Glycyrrhiza glabra extract 59870-68-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 40%
Supply Ability: 100kgs
Release date: 2024-07-16

Hebei Longbang Technology Co., Ltd

Product: Glabridin 59870-68-7
Price: US $4.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20TONS
Release date: 2024-05-07

59870-68-7, GlabridinRelated Search:

Dimethyl sulfide Dihydromyrcenol ETHANE Dimethyl ether Dimethyl fumarate Dimethyl sulfate Dimethyl carbonate DGL Dimethyl sebacate Dimethyl sulfoxide FLAVONE Isoflavone N,N-Dimethylformamide N-DECYL-BETA-D-GLUCOPYRANOSIDE glucosylglycerol TATM ISOFLAVONES Zinc Glycyrrhizinate acid 30% HPLC

1,3-Benzenediol, 4-(3,4-dihydro-8,8-diMethyl-2H,8H-benzo(1,2-b:3,4-b')dipyran-3-yl)-, (R)-

(R)-4-(3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-3-yl)-1,3-benzenediol

4-[(3R)-3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-3-yl]-1,3-benzenediol

Glabridin, >=98%

Glabridin/Propylene Glycol

4-[(3R)-8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol

Glabridin/OIL SOLUBLE LICORICE(GLYCYRRHIZA) EXTRACT

professional manufacturer Glabridin 59870-68-7

98% Glabridin 59870-68-7 Light-yellow powder

Light liquorice set

LGB-GD 90

LGB-GD 40

Soluble GLABRIDIN, Liposomal GLABRIDIN, GLABRIDIN NanoEmulsion, NanoActive GLABRIDIN

GLABRIDIN

4-[(3R)-8,8-Dimethyl-3,4-dihydro-2H-pyrano[6,5-f]chromen-3-yl]benzene-1,3-diol

4-((R)-8,8-Dimethyl-3,4-dihydro-2H,8H-benzo[1,2-B:4,3-B']dipyran-3-yl)-benzene-1,3-diol

Aids096010

Aids-096010

GLABRIDIN(RG)

GLABRIDIN (GLYCYRRHIZA GLABRA ROOT EXTRACT)

4-(8,8-DiMethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chroMen-3-yl)-benzene-1,3-diol

2H,8H-Benzo[1,2-b:3,4-b']dipyran,1,3-benzenediolderiv

Liquorice flavonoids

BioaActive Glabridin

Nanoactive Glabridin

Soluble Glabridin

Glabridin, froM Liquorice root

1,3-Benzenediol,4-[(3R)-3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-yl]-

Glabridin, 98%, from Liquorice root

KB-289522

LS-176045

Q-100692

Glabridin，96%

Glabridin USP/EP/BP

glabridin 90%

Licorice Extract – Glabridin

water soluble glabridin

(R)-4-(8,8-Dimethyl-2,3,4,8-tetrahydropyrano[2,3-f]chromen-3-yl)benzene-1,3-diol

Glabridin、Glycyrrhiza Glabra (Licorice) Root Extract

GlabridinQ: What is Glabridin Q: What is the CAS Number of Glabridin Q: What is the storage condition of Glabridin Q: What are the applications of Glabridin

Glabridin 90%(White powder)

Light licorice

Nano-Liposomal Glabridin, Water-Soluble Glabridin

Glabridin Glycyrrhiza extract

Guanggancao Ding

glabridine

Licorice root Extract Glabridin

Glycyrrhiza glabra extract 90% -called "Whitening Gold".

Glabridin -Glycyrrhiza glabra extract

Glabridin-RM

1,3-Benzenediol, 4-(3,4-dihydro-8,8-dimethyl-2H,8H-benzo(1,2-b:3,4-b')dipyran-3-yl)-, (R)-

Carbazochrome Impurity 26

59870-68-7

5987-68-7

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chemical reagent

pharmaceutical intermediate

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