2,4-Pyridinedicarboxylic acid

ChemicalBook > CAS DataBase List > 2,4-Pyridinedicarboxylic acid

2,4-Pyridinedicarboxylic acid

Product Name: 2,4-Pyridinedicarboxylic acid
CAS No.: 499-80-9
Chemical Name: 2,4-Pyridinedicarboxylic acid
Synonyms: 2,4-PDCA;2, 4-PDCA;lutidinicaci;LUTIDINIC ACID;4-Lutidinic Acid;2,4-LUTIDINIC ACID;RARECHEM AL BO 0286;Topirast impurity 10;2,4-Dicarboxypyridine;Tuobisite Impurity 20
CBNumber: CB7678217
Molecular Formula: C7H5NO4
Formula Weight: 167.12
MOL File: 499-80-9.mol

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2,4-Pyridinedicarboxylic acid Property

Melting point:: 243-246 °C
Boiling point:: 295.67°C (rough estimate)
Density: 1.5216 (rough estimate)
vapor pressure: 0.001Pa at 25℃
refractive index: 1.6280 (estimate)
storage temp.: Store below +30°C.
solubility: 2.49g/l
form: Crystalline Powder
pka: 2.15(at 25℃)
color: White to almost white
Water Solubility: Soluble in water at 20°C 4.5 g/L.
λmax: 258nm(MeOH aq.)(lit.)
BRN: 131631
LogP: 0.57
CAS DataBase Reference: 499-80-9(CAS DataBase Reference)
EPA Substance Registry System: 2,4-Pyridinedicarboxylic acid (499-80-9)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 24/25-26
WGK Germany: 3
TSCA: Yes
HS Code: 29333999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.21052
Product name: 2,4-Pyridinedicarboxylic acid
Purity: for synthesis
Packaging: 10g
Price: $148
Updated: 2024/03/01

Sigma-Aldrich

Product number: 04473
Product name: 2,4-Pyridinedicarboxylic acid
Purity: ≥98.0%
Packaging: 5g
Price: $252
Updated: 2024/03/01

TCI Chemical

Product number: P0553
Product name: 2,4-Pyridinedicarboxylic Acid
Purity: min. 98.0 %
Packaging: 25G
Price: $132
Updated: 2023/06/20

TCI Chemical

Product number: P0553
Product name: 2,4-Pyridinedicarboxylic Acid Hydrate
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $44
Updated: 2021/12/16

TCI Chemical

Product number: P2416
Product name: 2,4-Pyridinedicarboxylic Acid
Purity: >98.0%(GC)
Packaging: 5g
Price: $69
Updated: 2024/03/01

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2,4-Pyridinedicarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

white to almost white crystalline powder

Uses

2,4-Pyridinedicarboxylic Acid is a jumonji C (JmjC) histone demethylase inhibitor.

Uses

2,4-Pyridinedicarboxylic acid is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases. 2,4-Pyridinedicarboxylic acid has been used in a study to determine that ruthenium(II) complexes exert antimetastatic effects on several tumor cell lines in vitro, achieved mostly by the effect on cell adhesion, migration and angiogenesis. 2,4-Pyridinedicarboxylic acid has been used in a study to develop an assay that represents the first report of a RapidFire mass spectrometery assay for an epigenetics target.

Definition

ChEBI: A pyridinedicarboxylic acid carrying carboxy groups at positions 2 and 4.

Flammability and Explosibility

Not classified

Biological Activity

2,4-pyridinedicarboxylic acid (2,4-pdca) is an inhibitor of histone lysine-specific demethylases that targets on jmjd2a (kdm4a), kdm4c, kdm4e (ic50, 1.4 μm), kdm5b (ic50, 3 μm), kdm6a and other 2-oxogynases [1][2].histone lysine-specific demethylases jmjd2a (kdm4a) and kdm4c are both members of the jumonji domain 2 (jmjd2) family and function as trimethylation-specific demethylases, converting specific trimethylated histone residues to the dimethylated form. kdm5b is an h3k4me3⁄ me2-specific lysine demethylase [1][2].2,4-pyridinedicarboxylic acid (2,4-pdca) is an inhibitor of jmjd2a (kdm4a), kdm4c and kdm5b. in the fdh-coupled assay, 2,4-pdca inhibited cckdm5b with ic50 value of 3 ± 1 μm. in maldi-tof analysis of h3(1-21)k4me3, 2,4-pdca reduced the level of h3(1-15) induced by cckdm5b. in u2-os cells transfected with kdm5b, 2,4-pdca inhibited the decrease of h3k4me3 [1]. in hg-treated vsmcs, 2,4-pdca (1.0 mm) inhibited jmjd2a and hg-induced proliferation in a concentration-dependent way, and inhibited hg-induced migration. 2,4-pdca also reduced the mrna and protein levels of mcp-1 and il-6 [2].in diabetic rats, 2,4-pdca (7.5 mg/kg/d) reduced neointimal area and i/m ratio in the injured arteries 28 days after injury. 2,4-pdca also inhibited the percentage of pcna-positive cells in the neointima [2].

References

[1]. kristensen lh, nielsen al, helgstrand c, et al. studies of h3k4me3 demethylation by kdm5b/jarid1b/plu1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor. febs j, 2012, 279(11): 1905-1914.
[2]. qi h, jing z, xiaolin w, et al. histone demethylase jmjd2a inhibition attenuates neointimal hyperplasia in the carotid arteries of balloon-injured diabetic rats via transcriptional silencing: inflammatory gene expression in vascular smooth muscle cells. cell physiol biochem, 2015, 37(2): 719-734.

2,4-Pyridinedicarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

PYRIDINE-2,4-DIAMINE

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View Lastest Price from 2,4-Pyridinedicarboxylic acid manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: 2,4-Pyridinedicarboxylic acid 499-80-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-01

Shaanxi Dideu Medichem Co. Ltd

Product: 2,4-Pyridinedicarboxylic acid 499-80-9
Price: US $1.00-0.00/KG
Min. Order: 1KG
Purity: 99%+
Supply Ability: 10000KG
Release date: 2019-12-27

Henan Fengda Chemical Co., Ltd

Product: 2,4-Pyridinedicarboxylic acid 499-80-9
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-03

499-80-9, 2,4-Pyridinedicarboxylic acidRelated Search:

Citric acid Hyaluronic acid OXALIC ACID Pyridine Folic acid Ethyl 2-(Chlorosulfonyl)acetate 2,6-Lutidine DIPIPERIDINOMETHANE 2,4-PYRIDINECARBOXYLIC ACID, 4-METHYL ESTER Dimethyl 2,4-pyridinedicarboxylate Ascoric Acid 2,4-Pyridinedicarboxylic acid, 2-Methyl ester 4-Pyridinecarboxamide,2-cyano-(9CI) isonicotinamide 1-oxide Pyridine-4-carboxylic acid N-oxide 2-Pyridinemethanethiol 3,5-DIHYDROXYPYRIDINE PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE

RARECHEM AL BO 0286

PYRIDINE-2,4-DICARBOXYLIC ACID

LUTIDINIC ACID

2,4-LUTIDINIC ACID

2,4-PYRIDINEDICARBOXYLIC ACID

2,4-Pyridinedicarboxylic acid hydrate

2,4-PyridinecarboxylicAcid

2,4-Pyridinedicarboxylic acid hydrate, 99+%

Pyridine-2,4-dicarboxylic acid, 98%, may contain up to ca 10% water

2,4-Dicarboxylpyridine

Pyridine-2,4-dicarboxylic acid, 98%, may cont. up to ca 10% water

4-Lutidinic Acid

2,4-Pyridinedicarboxylic acid hydrate, 99+% 5GR

lutidinic acid (2,4-PDCA)

2,4-PyridinedicarboxylicAcidHydrate&gt

2, 4-PDCA

2,4-Dicarboxypyridine

2,4-PDCA

2,4-PYRIDINEDICARBOXYLIC ACID FOR SYNTHE

Topiroxostat Impurity 49

3-Diphenylisobenzofuran

2,4-Pyridinedicarboxylic acid (8CI, 9CI, ACI)

lutidinicaci

Tuobisite Impurity 20

2,4-PYRIDINEDICARBOXYLIC ACID Lutidinic acid

2,4-Pyridinedicarboxylic acid|||2,4-Dicarboxypyridine|||2, 4-PDCA|||2,4-PDCA

Tuobisite Impurity 10

Topirast impurity 10

lutidinic acid, 10 mM in DMSO

499-80-9

NC5H3COOH2

C7H5NO4xH2O

C7H5NO4

Heterocycle-Pyridine series

Piperidines ,Piperazines ,Homopiperidines