4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Uses

Product Name: 4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.: 478832-21-2
Chemical Name: 4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms: 1-Boc-4-Hydroxyazepane;N-Boc-4-hydroxyazepane;1-Boc-Hexahydro-1H-azepin...;N-BOC-HEXAHYDRO-1H-AZEPIN-4-OL;1-Boc-Hexahydro-1H-azepin-4-ol;4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;4-hydroxy-1-azepanecarboxylic acid tert-butyl ester;tert-Butyl 4-hydroxyhexahydro-1H-azepine-1-carboxylate;4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER, 95+%;1H-AZEPINE-1-CARBOXYLIC ACID, HEXAHYDRO-4-HYDROXY-, 1,1-DIMETHYLETHYL ESTER
CBNumber: CB7678424
Molecular Formula: C11H21NO3
Formula Weight: 215.29
MOL File: 478832-21-2.mol

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4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property

Boiling point:: 310.6±35.0 °C(Predicted)
Density: 1.079±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 15.06±0.20(Predicted)
Appearance: White to off-white Solid

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN2811
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: H829958
Product name: 4-Hydroxyazepane-1-carboxylicacidtert-butylester
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: H829958
Product name: 4-Hydroxyazepane-1-carboxylicacidtert-butylester
Packaging: 500mg
Price: $65
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-LP
Product name: 1-Boc-hexahydro-1H-azepin-4-ol
Packaging: 250mg
Price: $59
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-LP
Product name: 1-Boc-hexahydro-1H-azepin-4-ol
Packaging: 1g
Price: $119
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM1050601
Product name: 4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Purity: 95.00%
Packaging: 1G
Price: $160.65
Updated: 2021/12/16

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4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Uses

4-Hydroxyazine-1-carboxylic acid tert-butyl ester is a carboxylic acid ester organic compound that can be used as a pharmaceutical intermediate.

Synthesis

39888-51-2

24424-99-5

478832-21-2

(c) Synthesis of tert-butyl 4-hydroxyazepane-1-carboxylate: Ammonium formate (900 mg) and 10% palladium/carbon catalyst (200 mg) were added to an ethanol solution (10 mL) of 1-benzyl-4-azepane (450 mg, 2.19 mmol), and the reaction mixture was heated and refluxed for 1 hour. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated. The resulting residue was dissolved in dichloromethane (10 mL) and di-tert-butyl dicarbonate (0.504 mL, 2.19 mmol) was added at room temperature with continuous stirring for 19 hours. At the end of the reaction, saturated aqueous sodium bicarbonate solution was added to the mixture, followed by water and extraction with chloroform. The organic layers were combined, dried with anhydrous magnesium sulfate and the solvent was removed by distillation under reduced pressure. The resulting crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=2/1) to afford the target compound tert-butyl 4-hydroxyazepane-1-carboxylate (333 mg, 70% yield).

References

[1] Patent: EP1500643, 2005, A1. Location in patent: Page 48

4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers

China 102 Germany 1 India 1 United Kingdom 2 United States 14 Global 120

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View Lastest Price from 4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers

Career Henan Chemical Co

Product: 4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 478832-21-2
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 725
Release date: 2019-09-01

478832-21-2, 4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTERRelated Search:

4-Pyrimidinecarbonitrile (7CI,9CI) TERT-BUTYL 4-HYDROXYBUTYRATE 4-Hydroxyquinoline-6-carboxylic acid 4-cyanophenylacetaldehyde 4-Cyanobutyric acid ISOQUINOLINE-4-CARBONITRILE 4-Mercaptobenzyl alcohol 4-CYANO-2-METHOXYPYRIDINE 4-HYDROXY-8-CYANOQUINOLINE 2-(4-HYDROXYPHENYL)ACETALDEHYDE 4-CYANO-3-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE Cyclohexanecarbonitrile, 4-hydroxy- 4-HYDROXYPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE 2-Pyridinecarbonitrile,4-hydroxy-(9CI) 4-CYANOTHIAZOLE 1H-indazole-4-carbonitrile 4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-tert-Butyl 4-ethyl 5-hydroxyazepane-1,4-dicarboxylate

N-BOC-HEXAHYDRO-1H-AZEPIN-4-OL

1H-AZEPINE-1-CARBOXYLIC ACID, HEXAHYDRO-4-HYDROXY-, 1,1-DIMETHYLETHYL ESTER

4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

4-HYDROXYAZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER, 95+%

1-Boc-4-Hydroxyazepane

4-hydroxy-1-azepanecarboxylic acid tert-butyl ester

1-Boc-Hexahydro-1H-azepin-4-ol

1-Boc-Hexahydro-1H-azepin...

tert-Butyl 4-hydroxyhexahydro-1H-azepine-1-carboxylate

N-Boc-4-hydroxyazepane

478832-21-2

C11H21O3N