7-Nitroindole-2-carboxylic acid

Product Name: 7-Nitroindole-2-carboxylic acid
CAS No.: 6960-45-8
Chemical Name: 7-Nitroindole-2-carboxylic acid
Synonyms: 7-NO2-ICA;NSC 69877;CRT0044876;7-Nitro-1H-indoL;CRT0044876, >=97%;TIMTEC-BB SBB003487;NSC 69877,7-NO2-ICA;2-Carboxy-7-nitro-1H-indole;7-NITROINDOLE-2-CARBOXYLIC ACID;7-NITRO-1H-INDOLE-2-CARBOXYLATE
CBNumber: CB7682546
Molecular Formula: C9H6N2O4
Formula Weight: 206.15
MOL File: 6960-45-8.mol

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7-Nitroindole-2-carboxylic acid Property

Melting point:: 260-261 °C
Boiling point:: 344.99°C (rough estimate)
Density: 1.4588 (rough estimate)
refractive index: 1.5570 (estimate)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: DMSO: >20mg/mL
form: Tan solid
pka: 4.03±0.30(Predicted)
color: Light yellow to yellow
Water Solubility: Insoluble
CAS DataBase Reference: 6960-45-8(CAS DataBase Reference)
EPA Substance Registry System: 1H-Indole-2-carboxylic acid, 7-nitro- (6960-45-8)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 36/37/38-21/22-43-36
Safety Statements: 36/37/39-26-22-36/37
WGK Germany: 3
TSCA: Yes
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C0496
Product name: CRT0044876
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $92.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 262015
Product name: DNA Base Excision Repair Pathway Inhibitor
Packaging: 25mg
Price: $130
Updated: 2024/03/01

Alfa Aesar

Product number: B20786
Product name: 7-Nitroindole-2-carboxylic acid, 96%
Packaging: 1g
Price: $96.65
Updated: 2024/03/01

Alfa Aesar

Product number: B20786
Product name: 7-Nitroindole-2-carboxylic acid, 96%
Packaging: 5g
Price: $360.65
Updated: 2024/03/01

Cayman Chemical

Product number: 16348
Product name: DNA Base Excision Repair Pathway Inhibitor
Purity: ≥98%
Packaging: 10mg
Price: $44
Updated: 2024/03/01

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7-Nitroindole-2-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

brown powder

Uses

7-Nitro-1H-indole-2-carboxylic Acid is a potent and selective APE1 inhibitor, which at low micromolar concentrations inhibits the AP endonuclease, 3''-phosphodiesterase and 3''-phosphatase activities of APE1 .

Biological Activity

crt0044876 is a potent and selective inhibitor of ape1 with ic50 value of 3.06 μm [1].apurinic/apyrimidinic endonuclease-1 (ape1) is a member of the highly conserved exonucleaseiii family of ap endonucleases and plays an important role in dna repair. ape1 exhibits 3’-phosphodiesterase activity and weak 3’-phosphatase activity, 3’-5’-exonuclease activity and rnaseh activity [1].crt0044876 is a potent and selective ape1 inhibitor. in hela whole cell extract, crt0044876 inhibited apurinic/apyrimidinic (ap) site cleavage catalyzed by ape1. crt0044876 inhibited both the ap endonuclease and exonuclease activities of exonuclease iii, the bacterial homologue of ape1. crt0044876 inhibited the 3’-phosphoglycolate diesterase activity of ape1 with ic50 value of 5 μm and also inhibited 3’-phosphatase activity through binding to dna repair active site of ape1. in ht1080 fibrosarcoma cells, crt0044876 significantly increased ap site accumulation and was non-toxic at concentrations up to 400 μm. also, crt0044876 potentiated the cytotoxicity induced by alkylating agent mms, temozolomide, hydrogen peroxide and hmdurd through specific inhibition of the base excision repair (ber) pathway [1].

References

[1]. madhusudan s, smart f, shrimpton p, et al. isolation of a small molecule inhibitor of dna base excision repair. nucleic acids res, 2005, 33(15): 4711-4724.

7-Nitroindole-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 7-Nitroindole-2-carboxylic acid manufacturers

Career Henan Chemical Co

Product: 7-Nitroindole-2-carboxylic acid 6960-45-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 85.0-99.8%
Supply Ability: 20 tons
Release date: 2019-12-25

6960-45-8, 7-Nitroindole-2-carboxylic acidRelated Search:

Indole Ethyl 2-(Chlorosulfonyl)acetate 4-Nitrophenyl chloroformate Indole-2-carboxylic acid 2-Nitrobenzoic acid 4-Nitrobenzoic acid 7-Nitroindole 4-Nitrobenzyl chloroformate NITROGEN DIOXIDE 7-NITROINDOLE-2-CARBOXYLIC ACID ETHYL ESTER 5-NITROINDOLE-2-CARBOXYLIC ACID ETHYL ESTER 5-NITROINDOLE-3-CARBOXYLIC ACID 5-NITROINDOLE-2-CARBOXYLIC ACID 4-NITROINDOLE-3-CARBOXYLIC ACID ETHYL 3-FORMYL-7-NITRO-1H-INDOLE-2-CARBOXYLATE 5-METHOXY-7-NITRO-2-INDOLECARBOXYLIC ACID 5,7-DINITROINDOLE-2-CARBOXYLIC ACID ETHYL 3-(2-CARBOXY-VINYL)-7-NITRO-1H-INDOLE-2-CARBOXYLATE

TIMTEC-BB SBB003487

7-nitro-1h-indole-2-carboxylicaci

7-NITRO-1H-INDOLE-2-CARBOXYLIC ACID

7-NITROINDOLE-2-CARBOXYLIC ACID

7-Nitroindole-2-carboxylic acid, 90-95%

7-NO2-ICA

2-Carboxy-7-nitro-1H-indole

7-Nitro-1H-indole-2-carboxylic acid 95+%

7-Nitro-2H-indole-2-carboxylic acid

1H-Indole-2-carboxylic acid, 7-nitro-

DNA Base Excision Repair Pathway Inhibitor

Indole-2-carboxylic acid, 7-nitro-

Indole-2-carboxylic acid, 7-nitro- (8CI)

CRT0044876, >=97%

CRT0044876

NSC 69877,7-NO2-ICA

7-Nitroindole-2-carboxylic acid 7-Nitro-1H-indole-2-carboxylic acid

NSC 69877

7-NITRO-1H-INDOLE-2-CARBOXYLATE

7-Nitro-1H-indole-2-carboxylic acid 96+%

DNA Base Excision Repair Pathway Inhibitor - CAS 6960-45-8 - Calbiochem

7-Nitro-1H-indoL

7-Nitroindole-2-carboxylic acid USP/EP/BP

6960-45-8

Indoles and derivatives

Inhibitors