ChemicalBook > CAS DataBase List > Dimethyl methoxymethylenemalonate

Dimethyl methoxymethylenemalonate

Product Name
Dimethyl methoxymethylenemalonate
CAS No.
22398-14-7
Chemical Name
Dimethyl methoxymethylenemalonate
Synonyms
DiMethyl 2-(MethoxyMethylene)Malonate;MMMM;Dimethyl 2-(methoxymethylene);Dimethylmethoxymethylenmalonat;DIMETHYL METHOXYMETHYLENEMALONATE;DimethylMethoxymethylenemalonate>Dimethyl methoxymethylenemalonate, 98+%;thyl 2-(methoxymethylidene)propanedioate;imethyl2-(methoxymethylidene)propanedioate;METHOXYMETHYLENEMALONIC ACID DIMETHYL ESTER
CBNumber
CB7686827
Molecular Formula
C7H10O5
Formula Weight
174.15
MOL File
22398-14-7.mol
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Dimethyl methoxymethylenemalonate Property

Melting point:
40-44 °C
Boiling point:
98 °C (0.5 mmHg)
Density 
1.2311 (rough estimate)
refractive index 
1.4390 (estimate)
Flash point:
158 °C
storage temp. 
Sealed in dry,Room Temperature
form 
Crystalline Solid
color 
White
InChI
InChI=1S/C7H10O5/c1-10-4-5(6(8)11-2)7(9)12-3/h4H,1-3H3
InChIKey
RHFZTBSULNJWEI-UHFFFAOYSA-N
SMILES
C(OC)(=O)/C(=C\OC)/C(OC)=O
CAS DataBase Reference
22398-14-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
43-36/38-22
Safety Statements 
37/39-26-24
HS Code 
29171990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P284Wear respiratory protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M1207
Product name
Dimethyl Methoxymethylenemalonate
Purity
>98.0%(GC)
Packaging
25g
Price
$32
Updated
2022/04/27
TCI Chemical
Product number
M1207
Product name
Dimethyl Methoxymethylenemalonate
Purity
>98.0%(GC)
Packaging
500g
Price
$361
Updated
2021/12/16
Alfa Aesar
Product number
B23803
Product name
Dimethyl methoxymethylenemalonate, 98+%
Packaging
10g
Price
$32.4
Updated
2021/12/16
Alfa Aesar
Product number
B23803
Product name
Dimethyl methoxymethylenemalonate, 98+%
Packaging
50g
Price
$86.1
Updated
2021/12/16
Alfa Aesar
Product number
B23803
Product name
Dimethyl methoxymethylenemalonate
Purity
98+%
Packaging
250g
Price
$291
Updated
2021/12/16
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Dimethyl methoxymethylenemalonate Chemical Properties,Usage,Production

Chemical Properties

white crystalline solid

Uses

Dimethyl 2-(Methoxymethylene)malonate is a useful synthetic intermediate. It is used in preparation of (phenoxyethoxy)quinolones with antimalarial activities. It is also a reagent used in the synthesis of bicyclic pyridones prepn. as oral selective CB2 agonists with anti-pruritic activity.

Synthesis

264.2 g (2.0 mol) of dimethyl malonate, 637 g (6 mol) of trimethyl orthoformate and 20.4 g (0.2 mol) of acetic anhydride containing 2 g of H2 SO4 -activated bentonite were initially introduced into a reaction flask provided with a stirrer, thermometer, dropping funnel, column and reflux condensor, and the mixture was heated to boiling. 40.8 g (0.4 mol) of acetic anhydride was continuously metered for6 hours. The low boiling component formed was distilled off at a head temperature of 62° to 67° C. The bottom temperature increased slowly from 109° to 133° C. After 8 hours; the excess orthoester was distilled off at reduced pressure. 40.8 g (0.4 mol) of acetic anhydride was added to the remaining reaction mixture, and the mixture was heated at 140° C. for 2 hours. The catalyst was filtered off, and the crude product was distilled in vacuo. 330.4 g of dimethyl methoxymethylenemalonate (98% pure), having a melting point of 44° to 46° C., were obtained at 0.5 mbar and a head temperature of 110° C.

Dimethyl methoxymethylenemalonate Preparation Products And Raw materials

Raw materials

Preparation Products

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Dimethyl methoxymethylenemalonate Suppliers

Hangzhou Xiao Bei Medical Technology Co., LTD
Tel
+86-571-8526 3177 13962438025
Email
beixi.dong@heryipharma.com
Country
China
ProdList
164
Advantage
58
Haimen DsHare Pharmaceutical Technology Co., Ltd.
Tel
+86-0513-68050136 +86-13023574398
Fax
0513-68050130
Email
zhuwdsh@126.com
Country
China
ProdList
157
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
021-51613915-820 13611835272
Fax
021 51613951
Email
mmwang@sunwaypharm.cn
Country
China
ProdList
9734
Advantage
57
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12438
Advantage
60
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19172
Advantage
64
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View Lastest Price from Dimethyl methoxymethylenemalonate manufacturers

Career Henan Chemical Co
Product
DIMETHYL METHOXYMETHYLENEMALONATE 22398-14-7
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-10

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