ChemicalBook > CAS DataBase List > Dimethyl methoxymethylenemalonate

Dimethyl methoxymethylenemalonate

Product Name: Dimethyl methoxymethylenemalonate
CAS No.: 22398-14-7
Chemical Name: Dimethyl methoxymethylenemalonate
Synonyms: DiMethyl 2-(MethoxyMethylene)Malonate;MMMM;Dimethyl 2-(methoxymethylene);Dimethylmethoxymethylenmalonat;DIMETHYL METHOXYMETHYLENEMALONATE;DimethylMethoxymethylenemalonate>Dimethyl methoxymethylenemalonate, 98+%;thyl 2-(methoxymethylidene)propanedioate;imethyl2-(methoxymethylidene)propanedioate;METHOXYMETHYLENEMALONIC ACID DIMETHYL ESTER
CBNumber: CB7686827
Molecular Formula: C7H10O5
Formula Weight: 174.15
MOL File: 22398-14-7.mol

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Dimethyl methoxymethylenemalonate Property

Melting point:: 40-44 °C
Boiling point:: 98 °C (0.5 mmHg)
Density: 1.2311 (rough estimate)
refractive index: 1.4390 (estimate)
Flash point:: 158 °C
storage temp.: Sealed in dry,Room Temperature
form: Crystalline Solid
color: White
InChI: InChI=1S/C7H10O5/c1-10-4-5(6(8)11-2)7(9)12-3/h4H,1-3H3
InChIKey: RHFZTBSULNJWEI-UHFFFAOYSA-N
SMILES: C(OC)(=O)/C(=C\OC)/C(OC)=O
CAS DataBase Reference: 22398-14-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 43-36/38-22
Safety Statements: 37/39-26-24
HS Code: 29171990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P284Wear respiratory protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M1207
Product name: Dimethyl Methoxymethylenemalonate
Purity: >98.0%(GC)
Packaging: 25g
Price: $32
Updated: 2022/04/27

TCI Chemical

Product number: M1207
Product name: Dimethyl Methoxymethylenemalonate
Purity: >98.0%(GC)
Packaging: 500g
Price: $361
Updated: 2021/12/16

TRC

Product number: D447505
Product name: Dimethyl2-(Methoxymethylene)malonate
Packaging: 25mg
Price: $385
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0165100
Product name: DIMETHYL METHOXYMETHYLENEMALONATE
Purity: 98.00%
Packaging: 5MG
Price: $498.74
Updated: 2021/12/16

Crysdot

Product number: CD13017961
Product name: Dimethyl2-(methoxymethylene)malonate
Purity: 95+%
Packaging: 500g
Price: $440
Updated: 2021/12/16

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Dimethyl methoxymethylenemalonate Chemical Properties,Usage,Production

Chemical Properties

white crystalline solid

Uses

Dimethyl 2-(Methoxymethylene)malonate is a useful synthetic intermediate. It is used in preparation of (phenoxyethoxy)quinolones with antimalarial activities. It is also a reagent used in the synthesis of bicyclic pyridones prepn. as oral selective CB2 agonists with anti-pruritic activity.

Synthesis

264.2 g (2.0 mol) of dimethyl malonate, 637 g (6 mol) of trimethyl orthoformate and 20.4 g (0.2 mol) of acetic anhydride containing 2 g of H2 SO4 -activated bentonite were initially introduced into a reaction flask provided with a stirrer, thermometer, dropping funnel, column and reflux condensor, and the mixture was heated to boiling. 40.8 g (0.4 mol) of acetic anhydride was continuously metered for6 hours. The low boiling component formed was distilled off at a head temperature of 62° to 67° C. The bottom temperature increased slowly from 109° to 133° C. After 8 hours; the excess orthoester was distilled off at reduced pressure. 40.8 g (0.4 mol) of acetic anhydride was added to the remaining reaction mixture, and the mixture was heated at 140° C. for 2 hours. The catalyst was filtered off, and the crude product was distilled in vacuo. 330.4 g of dimethyl methoxymethylenemalonate (98% pure), having a melting point of 44° to 46° C., were obtained at 0.5 mbar and a head temperature of 110° C.

Dimethyl methoxymethylenemalonate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Dimethyl methoxymethylenemalonate manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Dimethyl methoxymethylenemalonate 22398-14-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-07-05

Career Henan Chemical Co

Product: DIMETHYL METHOXYMETHYLENEMALONATE 22398-14-7
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-10

22398-14-7, Dimethyl methoxymethylenemalonateRelated Search:

isopropyl 2-Methoxyacetate (Z)-2-Methoxyimino-2-(furyl-2-yl) acetic acid ammonium salt Methyl (triphenylphosphoranylidene)acetate (Carbomethoxymethyl)triphenylphosphonium bromide Methoxyammonium chloride DIMETHYL METHOXYMALONATE Dibutyl maleate Dimethyl methylmalonate Dimethyl malonate DIMETHYL METHOXYMETHYLENEMALONATE ((MMMM) DIMETHYL METHOXYMETHYLENEMALONATE SALOR-INT L305529-1EA Diethyl ethoxymethylenemalonate

METHOXYMETHYLENEMALONIC ACID DIMETHYL ESTER

DIMETHYL METHOXYMETHYLENEMALONATE

MMMM

Dimethyl methoxymethylenemalonate, 98+%

Dimethylmethoxymethylenmalonat

DiMethyl 2-(MethoxyMethylene)Malonate

Propanedioic acid, 2-(methoxymethylene)-, 1,3-dimethyl ester

1,3-dimethyl 2-(methoxymethylidene)propanedioate

Dimethyl 2-(methoxymethylene)

Propanedioic acid, (methoxymethylene)-, dimethyl ester

2-methoxy-5,5-dimethyl-1,3-dioxane-4,6-dione

DimethylMethoxymethylenemalonate&gt

Dimethyl 2-(methoxymethylidene)propanedioate

imethyl2-(methoxymethylidene)propanedioate

thyl 2-(methoxymethylidene)propanedioate

1,3-Dimethyl 2-(methoxymethylene)propanedioate

2-Methoxymethylene-malonic acid dimethyl ester

22398-14-7

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