ChemicalBook > CAS DataBase List > Dimethyl methoxymethylenemalonate

Dimethyl methoxymethylenemalonate

Product Name
Dimethyl methoxymethylenemalonate
CAS No.
22398-14-7
Chemical Name
Dimethyl methoxymethylenemalonate
Synonyms
DiMethyl 2-(MethoxyMethylene)Malonate;MMMM;Dimethyl 2-(methoxymethylene);Dimethylmethoxymethylenmalonat;DIMETHYL METHOXYMETHYLENEMALONATE;DimethylMethoxymethylenemalonate>Dimethyl methoxymethylenemalonate, 98+%;thyl 2-(methoxymethylidene)propanedioate;imethyl2-(methoxymethylidene)propanedioate;METHOXYMETHYLENEMALONIC ACID DIMETHYL ESTER
CBNumber
CB7686827
Molecular Formula
C7H10O5
Formula Weight
174.15
MOL File
22398-14-7.mol
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Dimethyl methoxymethylenemalonate Property

Melting point:
40-44 °C
Boiling point:
98 °C (0.5 mmHg)
Density 
1.2311 (rough estimate)
refractive index 
1.4390 (estimate)
Flash point:
158 °C
storage temp. 
Sealed in dry,Room Temperature
form 
Crystalline Solid
color 
White
InChI
InChI=1S/C7H10O5/c1-10-4-5(6(8)11-2)7(9)12-3/h4H,1-3H3
InChIKey
RHFZTBSULNJWEI-UHFFFAOYSA-N
SMILES
C(OC)(=O)/C(=C\OC)/C(OC)=O
CAS DataBase Reference
22398-14-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
43-36/38-22
Safety Statements 
37/39-26-24
HS Code 
29171990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P284Wear respiratory protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M1207
Product name
Dimethyl Methoxymethylenemalonate
Purity
>98.0%(GC)
Packaging
25g
Price
$32
Updated
2022/04/27
TCI Chemical
Product number
M1207
Product name
Dimethyl Methoxymethylenemalonate
Purity
>98.0%(GC)
Packaging
500g
Price
$361
Updated
2021/12/16
Alfa Aesar
Product number
B23803
Product name
Dimethyl methoxymethylenemalonate, 98+%
Packaging
10g
Price
$32.4
Updated
2021/12/16
Alfa Aesar
Product number
B23803
Product name
Dimethyl methoxymethylenemalonate, 98+%
Packaging
50g
Price
$86.1
Updated
2021/12/16
Alfa Aesar
Product number
B23803
Product name
Dimethyl methoxymethylenemalonate
Purity
98+%
Packaging
250g
Price
$291
Updated
2021/12/16
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Dimethyl methoxymethylenemalonate Chemical Properties,Usage,Production

Chemical Properties

white crystalline solid

Uses

Dimethyl 2-(Methoxymethylene)malonate is a useful synthetic intermediate. It is used in preparation of (phenoxyethoxy)quinolones with antimalarial activities. It is also a reagent used in the synthesis of bicyclic pyridones prepn. as oral selective CB2 agonists with anti-pruritic activity.

Synthesis

264.2 g (2.0 mol) of dimethyl malonate, 637 g (6 mol) of trimethyl orthoformate and 20.4 g (0.2 mol) of acetic anhydride containing 2 g of H2 SO4 -activated bentonite were initially introduced into a reaction flask provided with a stirrer, thermometer, dropping funnel, column and reflux condensor, and the mixture was heated to boiling. 40.8 g (0.4 mol) of acetic anhydride was continuously metered for6 hours. The low boiling component formed was distilled off at a head temperature of 62° to 67° C. The bottom temperature increased slowly from 109° to 133° C. After 8 hours; the excess orthoester was distilled off at reduced pressure. 40.8 g (0.4 mol) of acetic anhydride was added to the remaining reaction mixture, and the mixture was heated at 140° C. for 2 hours. The catalyst was filtered off, and the crude product was distilled in vacuo. 330.4 g of dimethyl methoxymethylenemalonate (98% pure), having a melting point of 44° to 46° C., were obtained at 0.5 mbar and a head temperature of 110° C.

Dimethyl methoxymethylenemalonate Preparation Products And Raw materials

Raw materials

Preparation Products

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Dimethyl methoxymethylenemalonate Suppliers

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View Lastest Price from Dimethyl methoxymethylenemalonate manufacturers

Career Henan Chemical Co
Product
DIMETHYL METHOXYMETHYLENEMALONATE 22398-14-7
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-10

22398-14-7, Dimethyl methoxymethylenemalonateRelated Search:

isopropyl 2-Methoxyacetate (Z)-2-Methoxyimino-2-(furyl-2-yl) acetic acid ammonium salt Methyl (triphenylphosphoranylidene)acetate (Carbomethoxymethyl)triphenylphosphonium bromide Methoxyammonium chloride DIMETHYL METHOXYMALONATE Dibutyl maleate Dimethyl methylmalonate Dimethyl malonate DIMETHYL METHOXYMETHYLENEMALONATE ((MMMM) DIMETHYL METHOXYMETHYLENEMALONATE SALOR-INT L305529-1EA Diethyl ethoxymethylenemalonate

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