ChemicalBook > CAS DataBase List > 3-Hydroxypiperidine
3-Hydroxypiperidine
Background- Product Name
- 3-Hydroxypiperidine
- CAS No.
- 6859-99-0
- Chemical Name
- 3-Hydroxypiperidine
- Synonyms
- PIPERIDIN-3-OL;3-PIPERIDINOL;Benidipine Impurity 17;3-hydroxyperidine;3-HYDROXYPIPERIDINE;3-Hydroxypiperadine;OEM 3-Hydroxypiperidin;3-Hydroxypiperidine>3-HYDROXYPIPERIDINE 98%;(3R)-3-piperidin-1-iumol
- CBNumber
- CB7687884
- Molecular Formula
- C5H11NO
- Formula Weight
- 101.15
- MOL File
- 6859-99-0.mol
More
Less
3-Hydroxypiperidine Property
- Melting point:
- 57-61 °C
- Boiling point:
- 67-69 °C (2 mmHg)
- Density
- 1.016±0.06 g/cm3(Predicted)
- Flash point:
- >100°C
- storage temp.
- 2-8°C
- solubility
- ethanol: 0.1 g/mL, clear
- pka
- 14.91±0.20(Predicted)
- form
- Crystalline Powder and Lumps
- color
- White to light yellow
- PH
- 11.5-11.7 (H2O)Aqueous solution
- Water Solubility
- soluble
- Sensitive
- Air Sensitive & Hygroscopic
- BRN
- 102696
- InChIKey
- BIWOSRSKDCZIFM-UHFFFAOYSA-N
- LogP
- -0.35
- CAS DataBase Reference
- 6859-99-0(CAS DataBase Reference)
More
Less
Safety
- Hazard Codes
- C,Xi
- Risk Statements
- 34-20/21/22-36/37/38
- Safety Statements
- 26-36/37/39-45-27
- RIDADR
- UN 3263 8/PG 2
- WGK Germany
- 3
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29333990
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 56210
- Product name
- 3-Hydroxypiperidine
- Purity
- 99%
- Packaging
- 10g
- Price
- $38.58
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 56210
- Product name
- 3-Hydroxypiperidine
- Purity
- ≥98.0% (NT)
- Packaging
- 50g
- Price
- $115.8
- Updated
- 2024/03/01
TCI Chemical
- Product number
- H0412
- Product name
- 3-Hydroxypiperidine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $28
- Updated
- 2024/03/01
TCI Chemical
- Product number
- H0412
- Product name
- 3-Hydroxypiperidine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $88
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- L01333
- Product name
- 3-Hydroxypiperidine, 98+%
- Packaging
- 2g
- Price
- $18.65
- Updated
- 2024/03/01
More
Less
3-Hydroxypiperidine Chemical Properties,Usage,Production
Background
Many piperidine derivatives have multiple pharmacological activities such as antibacterial, antitumor, treatment of Alzheimer's disease and anesthesia. They are also important drugs for the treatment of viral infections (including AIDS) and diabetes. 3-Hydroxypiperidine or its derivatives are one of the important intermediates, which are widely used in the synthesis of drug intermediates such as chiral 3-aminopiperidine. It is of great significance to develop a synthesis method suitable for industrial production.
Chemical Properties
White to light yellow crystalline powder and lumps
Application
3-Hydroxypiperidine may be used to synthesize the following:
2-pyrrolidinone via oxidation with iodosylbenzene
1-[2,8-bis(trifluoromethyl)quinolin-4-yl]piperidin-3-ol via reaction with 4-bromoquinoline
Reactant for:
Synthesis of unsymmetrical ureas
Synthesis of piperidine nucleoside analogs
Fluorination reactions
Synthesis of substituted pyridines
Uses
3-Hydroxypiperidine is usually used for Synthesis of unsymmetrical ureas,Synthesis of piperidine nucleoside analogs,Fluorination reactions,Synthesis of substituted pyridines.
General Description
3-Hydroxypiperidine can be obtained from the reduction of 3-hydroxypyridine.
Synthesis
Dissolve 86.0g of 5-bromo-2-hydroxypentylamine hydrobromide in 150mL of water, and add a solution of 60mL of water containing 15.0g of sodium carbonate at 10-15°C, and drip it for about 1 hour. After dripping, react at about 15°C for 2 hours. Then heat to 30-40°C and react for 2 hours. Stop the reaction, cool it to room temperature, and concentrate the reaction solution under reduced pressure to remove most of the water. Filter it to remove salt, wash it with cold water, and continue to concentrate the mother liquor. The crude product is distilled under reduced pressure to obtain 26.5g of colourless oily 3-hydroxypiperidine, yielding 80%.
3-Hydroxypiperidine Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
3-Hydroxypiperidine Suppliers
- Tel
- 0518-87108777 13585296001
- haizaofu@163.com
- Country
- China
- ProdList
- 42
- Advantage
- 58
- Tel
- 028-61550113 13981882980
- 2277503856@qq.com
- Country
- China
- ProdList
- 15
- Advantage
- 58
- Tel
- 021-021-021-65281118 15921781258
- Fax
- 021-6528 2963
- sales@yongzchem.com
- Country
- China
- ProdList
- 66
- Advantage
- 58
- Tel
- 21-31038972 15721252604
- Fax
- +86-21-51385350
- ammyzuo@harvest-chem.com
- Country
- China
- ProdList
- 2540
- Advantage
- 64
- Tel
- 0531-82375880 15098789112
- 2710825968@qq.com
- Country
- China
- ProdList
- 309
- Advantage
- 58
- Tel
- 0579-86886233 18006543966
- Fax
- QQ：355093164
- 355093164@qq.com
- Country
- China
- ProdList
- 103
- Advantage
- 58
- Tel
- 13347833233
- 120300346@qq.com
- Country
- China
- ProdList
- 31
- Advantage
- 58
- Tel
- 18560810705
- 354907727@qq.com
- Country
- China
- ProdList
- 172
- Advantage
- 58
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-61259108 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44688
- Advantage
- 61
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- sales@capotchem.com
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 010-82967028 13552068683
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12390
- Advantage
- 60
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- +86-28-86127071
- Fax
- +86-28-86127072
- info@sino-produce.com
- Country
- China
- ProdList
- 406
- Advantage
- 66
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9512
- Advantage
- 66
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11655
- Advantage
- 64
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 19179
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42958
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 028-84252981
- Fax
- +86-28-84252965
- sales@chembon.com.cn
- Country
- China
- ProdList
- 814
- Advantage
- 64
- Tel
- 15527768850
- 1791901229@qq.com
- Country
- China
- ProdList
- 8836
- Advantage
- 52
- Tel
- 021-58955608,2250286 15921236618
- blinkzeng@gmail.com
- Country
- China
- ProdList
- 522
- Advantage
- 62
- Tel
- 15050866711
- Fax
- QQ:2677337387
- saleszchem@163.com
- Country
- China
- ProdList
- 110
- Advantage
- 62
- Tel
- 400-1166-196 18981987031
- Fax
- 028-84555506 800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 11707
- Advantage
- 57
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14435
- Advantage
- 57
- Tel
- 86-21-63210123
- Fax
- 86-21-63290778 86-21-63218885
- sj_scrc@sinopharm.com
- Country
- China
- ProdList
- 9815
- Advantage
- 79
- Tel
- 021-51613915-820 13611835272
- Fax
- 021 51613951
- mmwang@sunwaypharm.cn
- Country
- China
- ProdList
- 9734
- Advantage
- 57
- Tel
- 0731-85526065 13308475853
- ivy@hnhbsj.com
- Country
- China
- ProdList
- 4554
- Advantage
- 62
- Tel
- Please Send Email 18652950785
- Fax
- 025-87193546
- chemweiao@163.com
- Country
- China
- ProdList
- 4378
- Advantage
- 65
- Tel
- 0086-755-86198205
- acinfo@aemonchem.com
- Country
- China
- ProdList
- 1931
- Advantage
- 57
- Tel
- +86 (573) 82222445 (0)18006601000 452520369
- Fax
- +86 (573) 82222643
- sales@maya-r.com
- Country
- China
- ProdList
- 11707
- Advantage
- 57
- Tel
- 0370-2785118 17550508557
- Fax
- QQ：3470079902
- 675141927@qq.com
- Country
- China
- ProdList
- 3203
- Advantage
- 55
- Tel
- 021-56491756 13512199871
- Fax
- 021-5649-1756
- 2819742715@qq.com
- Country
- China
- ProdList
- 4000
- Advantage
- 55
- Tel
- 18030648795 18030648795
- Fax
- 028-61777050
- sales@cdforestchem.com
- Country
- China
- ProdList
- 1997
- Advantage
- 58
- Tel
- 021-50793966 18917198199
- Fax
- +86-21-50793967
- info@synfarm.com
- Country
- China
- ProdList
- 280
- Advantage
- 58
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9865
- Advantage
- 52
- Tel
- 800-810-5118
- Fax
- +86-10-84193589
- cnchemical@thermofisher.com
- Country
- China
- ProdList
- 17770
- Advantage
- 75
- Tel
- 400-810-7969 010-59572699
- Fax
- 010-59572688
- ningzi.li@inno-chem.com.cn
- Country
- China
- ProdList
- 6134
- Advantage
- 55
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- 13901585132
- Fax
- +86-25-52131256
- 799750417@qq.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- 18017383231 18017383231
- Fax
- qq：2817624287
- lyh_antaeus@163.com
- Country
- China
- ProdList
- 9347
- Advantage
- 55
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
- Tel
- 400-400-6206333 18521732826
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 021-61552785
- Fax
- 021-55660885
- sales@shshiji.com
- Country
- China
- ProdList
- 9545
- Advantage
- 55
- Tel
- 021-60451682 15021268886
- Fax
- +86-21-60451682
- sales@arborchemical.com
- Country
- China
- ProdList
- 856
- Advantage
- 55
- Tel
- 86-0755-86635001
- Fax
- 86-0755-22642228
- cantotech@126.com
- Country
- China
- ProdList
- 4566
- Advantage
- 55
- Tel
- +86-021-50935922
- Fax
- +86-021-33847795
- Country
- China
- ProdList
- 7865
- Advantage
- 55
More
Less
View Lastest Price from 3-Hydroxypiperidine manufacturers
Anhui Dexinjia Biopharm Co., Ltd
- Product
- 3-Hydroxypiperidine 6859-99-0
- Price
- US $100.00-2000.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 5MT per Month
- Release date
- 2021-01-11
Shanghai Yongzeng Technology Co.,Ltd
- Product
- 3-Hydroxypiperidine 6859-99-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kgs
- Release date
- 2024-09-03
Hebei Kingfiner Technology Development Co.Ltd
- Product
- 3-Hydroxypiperidine 6859-99-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 50000kg
- Release date
- 2024-06-19
6859-99-0, 3-HydroxypiperidineRelated Search:
2,2,6,6-Tetramethyl-4-piperidinol
DROPERIDOL
3,5-Dihydroxybenzoic acid
Haloperidol
PHENCYCLIDINE-D5 HYDROCHLORIDE
4-HYDROXYPIPERIDINE 98.5%,4-Hydroxypiperidine, 99+%,4-HYDROXYPIPERIDINE=4-PIPERIDIOL,4-Hydroxypiperidine 98%
SWAINSONINE
3-Quinuclidinyl benzilate
3-Quinuclidinol hydrochloride
3-Hydroxy-1-methylpiperidine
VERATRINE
Naloxone hydrochloride
3-hydroxypiperidin-2-one
4-[4-Chloro-3-(trifluoro methyl)phenyl]-4-hydroxypiperidine
3-HYDROXYPIPERIDINE HCL 98+%
PIPERIDOLATE HYDROCHLORIDE
1-Deoxynojirimycin
Diphenoxylate