4-Bromo-3-(trifluoromethyl)phenol

Product Name: 4-Bromo-3-(trifluoromethyl)phenol
CAS No.: 320-49-0
Chemical Name: 4-Bromo-3-(trifluoromethyl)phenol
Synonyms: 4-bromo-3-trifluromethylphenol;3-TRIFLUOROMETHYL-4-BROMO PHENOL;4-BROMO-3-(TRIFLUOROMETHYL)PHENOL;2-BROMO-5-HYDROXYBENZOTRIFLUORIDE;Phenol,4-bromo-3-(trifluoromethyl)-;4-BROMO-3-TRIFLUOROMETHYLPHENOL 98%;2-Bromo-5-hydroxybenzotrifluoride99%;2-Bromo-5-hydroxybenzotrifluoride 99%;4-Bromo-3-(trifluoromethyl)phenol >4-Bromo-3-(trifluoromethyl)phenol,98%
CBNumber: CB7702051
Molecular Formula: C7H4BrF3O
Formula Weight: 241.01
MOL File: 320-49-0.mol

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4-Bromo-3-(trifluoromethyl)phenol Property

Melting point:: 44-46°C
Boiling point:: 61-63 °C(Press: 3.5-4.0 Torr)
Density: 1.752±0.06 g/cm3(Predicted)
Flash point:: >110°(230°F)
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Methanol
pka: 8.39±0.18(Predicted)
form: Solid
color: Yellow
InChI: InChI=1S/C7H4BrF3O/c8-6-2-1-4(12)3-5(6)7(9,10)11/h1-3,12H
InChIKey: VOWPIDJSINRFPZ-UHFFFAOYSA-N
SMILES: C1(O)=CC=C(Br)C(C(F)(F)F)=C1
CAS DataBase Reference: 320-49-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HazardClass: 8
HS Code: 2908190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4494
Product name: 4-Bromo-3-(trifluoromethyl)phenol
Purity: >98.0%(GC)
Packaging: 1g
Price: $23
Updated: 2025/07/31

TCI Chemical

Product number: B4494
Product name: 4-Bromo-3-(trifluoromethyl)phenol
Purity: >98.0%(GC)
Packaging: 5g
Price: $65
Updated: 2025/07/31

TRC

Product number: B695960
Product name: 4-Bromo-3-(trifluoromethyl)phenol
Packaging: 1g
Price: $75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0018759
Product name: 2-BROMO-5-HYDROXYBENZOTRIFLUORIDE
Purity: 95.00%
Packaging: 1G
Price: $647.36
Updated: 2021/12/16

AK Scientific

Product number: J98124
Product name: 4-Bromo-3-(trifluoromethyl)phenol
Packaging: 5g
Price: $30
Updated: 2021/12/16

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4-Bromo-3-(trifluoromethyl)phenol Chemical Properties,Usage,Production

Chemical Properties

light yellow crystalline powder

Synthesis

98-17-9

320-49-0

General procedure for the synthesis of 3-trifluoromethyl-4-bromophenol from 3-trifluoromethylphenol: To a solution of 3-trifluoromethylphenol (7.50 mL, 62 mmol) was added dropwise bromine (3.47 mL, 68 mmol) and the reaction mixture was stirred overnight at room temperature. After completion of the reaction, the mixture was poured into water and extracted with dichloromethane. The organic layers were combined and washed sequentially with 4% sodium bicarbonate solution and saturated saline. The solvent was removed by distillation under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with hexane/ethyl acetate solvent mixture as mobile phase. Finally, 5.17 g of 3-trifluoromethyl-4-bromophenol was obtained in 30% yield. lRMS: m/z 241 (M-1)+; retention time: 6.18 min (Method B). 1H NMR (400 MHz, CDCl3) δ 7.53 (d, J = 8.6 Hz, 1H), 7.19 (d, J = 2.9 Hz, 1H), 6.87 (dd. J = 8.6, 2.9 Hz, 1H), 5.98 (s, 1H).

References

[1] Patent: WO2011/35900, 2011, A1. Location in patent: Page/Page column 80
[2] Patent: WO2004/35556, 2004, A1. Location in patent: Page 94
[3] Patent: US5183934, 1993, A
[4] Patent: EP423991, 1991, A2

4-Bromo-3-(trifluoromethyl)phenol Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-3-(trifluoromethyl)phenol Suppliers

Americas 1 CHINA 156 Europe 3 Germany 2 India 6 Italy 1 Japan 2 Ukraine 1 United Kingdom 9 United States 30 Global 211

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View Lastest Price from 4-Bromo-3-(trifluoromethyl)phenol manufacturers

Career Henan Chemical Co

Product: 2-Bromo-5-hydroxybenzotrifluoride 320-49-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98%HPLC
Supply Ability: g/kg/ton
Release date: 2020-02-01

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