4-Bromo-3-(trifluoromethyl)aniline

Product Name: 4-Bromo-3-(trifluoromethyl)aniline
CAS No.: 393-36-2
Chemical Name: 4-Bromo-3-(trifluoromethyl)aniline
Synonyms: BUTTPARK 37\11-68;5-AMINO-2-BROMOBE;5-Amino-2-bromobenzotrifluo;Amino-2-bromobenzotrifluoride;3-Trifluoromethyl-4-bromoanili;2-BROMO-5-AMINOBENZOTRIFLUORIDE;5-AMINO-2-BROMOBENZOTRIFLUORIDE;3-trifluoromethyl-4-bromoaniline;4-BROMO-3-(TRIFLUOROMETHYL)ANILINE;5-Amino-2-bromobenzotrifluoride97%
CBNumber: CB9242401
Molecular Formula: C7H5BrF3N
Formula Weight: 240.02
MOL File: 393-36-2.mol

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4-Bromo-3-(trifluoromethyl)aniline Property

Melting point:: 47-49 °C(lit.)
Boiling point:: 81-84 °C0.5 mm Hg(lit.)
Density: 1.6925 (rough estimate)
refractive index: 1.5320 (estimate)
Flash point:: >230 °F
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: soluble in Methanol
form: Solid:crystalline
pka: 2.67±0.10(Predicted)
color: White to Orange to Green
PH: 6.86 at 25℃ and 10g/L
BRN: 641589
LogP: 2.7 at 30℃
CAS DataBase Reference: 393-36-2(CAS DataBase Reference)
NIST Chemistry Reference: 5-Amino-2-bromobenzotrifluoride(393-36-2)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36
RIDADR: 2811
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
HS Code: 29214300

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 297712
Product name: 4-Bromo-3-(trifluoromethyl)aniline
Purity: 98%
Packaging: 5g
Price: $50
Updated: 2023/06/20

Sigma-Aldrich

Product number: 297712
Product name: 4-Bromo-3-(trifluoromethyl)aniline
Purity: 98%
Packaging: 25g
Price: $147
Updated: 2023/06/20

TCI Chemical

Product number: A1847
Product name: 5-Amino-2-bromobenzotrifluoride
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $30
Updated: 2025/07/31

TCI Chemical

Product number: A1847
Product name: 5-Amino-2-bromobenzotrifluoride
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $85
Updated: 2025/07/31

TRC

Product number: B810695
Product name: 4-Bromo-3-(trifluoromethyl)aniline
Packaging: 250mg
Price: $45
Updated: 2021/12/16

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4-Bromo-3-(trifluoromethyl)aniline Chemical Properties,Usage,Production

Chemical Properties

White to off-white crystalline

Uses

4-Bromo-3-(trifluoromethyl)aniline has been used in the preparation of:

2,5-dibromo-(trifluoromethyl)benzene and 2-bromo-5-iodo-(trifluoromethyl)benzene
AUY954, an aminocarboxylate analog of FTY720, a low nanomolar, monoselective agonist of the sphingosine-1-phosphate receptor

Synthesis

367-67-9

393-36-2

General procedure for the synthesis of 5-amino-2-bromobenzotrifluoride from 2-bromo-5-nitrobenzotrifluoride: 300 mL of methanol, 284 g of 2-bromo-5-nitrobenzotrifluoride, 20 g of Raney Ni Catalyst, and 1.0 g of piperazine were added to a 1 L high pressure hydrogenation reactor. The air in the reactor was replaced with hydrogen 3-4 times, followed by the hydrogenation reaction at a hydrogen pressure of 0.8-1.0 MPa and 80-90 °C until no more hydrogen was consumed. Upon completion of the reaction, the reaction mixture was cooled and filtered to remove the Raney Ni catalyst. Methanol and water were removed by distillation under reduced pressure, and the final product was obtained by simple distillation as a pale yellow liquid product, 5-amino-2-bromobenzotrifluoride, 250 g, with a GC purity of 95% and a yield of 98.8%.The Raney Ni catalyst and the solvent, methanol, can be recovered for reuse.

References

[1] Patent: CN106905104, 2017, A. Location in patent: Paragraph 0020; 0022
[2] Journal of the American Chemical Society, 1951, vol. 73, p. 3932

4-Bromo-3-(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-3-(trifluoromethyl)aniline Suppliers

Americas 1 Canada 2 China 297 Europe 3 France 1 Germany 2 India 15 Italy 1 Japan 3 Slovakia 1 Switzerland 2 Ukraine 2 United Kingdom 20 United States 44 Global 394

Shanghai Boyle Chemical Co., Ltd.

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View Lastest Price from 4-Bromo-3-(trifluoromethyl)aniline manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 4-Bromo-3-(trifluoromethyl)aniline 393-36-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-07-01

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Bromo-3-(trifluoromethyl)aniline 393-36-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-28

Hangzhou ICH Biofarm Co., Ltd

Product: 4-Bromo-3-(trifluoromethyl)aniline 393-36-2
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: 99.0%min
Supply Ability: 20000kg
Release date: 2023-06-28

393-36-2, 4-Bromo-3-(trifluoromethyl)anilineRelated Search:

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4-Bromo-3-(trifluoromethyl)aniline 98%min

5-Amino-2-bromobenzotrifluoride &gt

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4-Bromo-3-(trifluoromethyl)aniline ISO 9001：2015 REACH

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393-36-2

393-63-6

93-36-2

396-36-2

BrC6H3CF3NH2

Organic Building Blocks

Nitrogen Compounds

C7

Building Blocks

Amines

Miscellaneous

Benzotrifluoride Series

C7

Nitrogen Compounds

Aniline series

Aniline

Amines

blocks

Bromides

Building Blocks

Chemical Synthesis

Nitrogen Compounds

Organic Building Blocks

Trifluoromethylbenzene serise

amine| alkyl bromide

bc0001