ChemicalBook > CAS DataBase List > 4-Bromo-3-(trifluoromethyl)aniline

4-Bromo-3-(trifluoromethyl)aniline

Product Name
4-Bromo-3-(trifluoromethyl)aniline
CAS No.
393-36-2
Chemical Name
4-Bromo-3-(trifluoromethyl)aniline
Synonyms
BUTTPARK 37\11-68;5-AMINO-2-BROMOBE;5-Amino-2-bromobenzotrifluo;Amino-2-bromobenzotrifluoride;3-Trifluoromethyl-4-bromoanili;2-BROMO-5-AMINOBENZOTRIFLUORIDE;5-AMINO-2-BROMOBENZOTRIFLUORIDE;3-trifluoromethyl-4-bromoaniline;4-BROMO-3-(TRIFLUOROMETHYL)ANILINE;5-Amino-2-bromobenzotrifluoride97%
CBNumber
CB9242401
Molecular Formula
C7H5BrF3N
Formula Weight
240.02
MOL File
393-36-2.mol
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4-Bromo-3-(trifluoromethyl)aniline Property

Melting point:
47-49 °C(lit.)
Boiling point:
81-84 °C0.5 mm Hg(lit.)
Density 
1.6925 (rough estimate)
refractive index 
1.5320 (estimate)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
soluble in Methanol
form 
Solid:crystalline
pka
2.67±0.10(Predicted)
color 
White to Orange to Green
PH
6.86 at 25℃ and 10g/L
BRN 
641589
LogP
2.7 at 30℃
CAS DataBase Reference
393-36-2(CAS DataBase Reference)
NIST Chemistry Reference
5-Amino-2-bromobenzotrifluoride(393-36-2)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36
RIDADR 
2811
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
6.1
HS Code 
29214300
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
297712
Product name
4-Bromo-3-(trifluoromethyl)aniline
Purity
98%
Packaging
5g
Price
$50
Updated
2023/06/20
Sigma-Aldrich
Product number
297712
Product name
4-Bromo-3-(trifluoromethyl)aniline
Purity
98%
Packaging
25g
Price
$147
Updated
2023/06/20
TCI Chemical
Product number
A1847
Product name
5-Amino-2-bromobenzotrifluoride
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$30
Updated
2025/07/31
TCI Chemical
Product number
A1847
Product name
5-Amino-2-bromobenzotrifluoride
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$85
Updated
2025/07/31
TRC
Product number
B810695
Product name
4-Bromo-3-(trifluoromethyl)aniline
Packaging
250mg
Price
$45
Updated
2021/12/16
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4-Bromo-3-(trifluoromethyl)aniline Chemical Properties,Usage,Production

Chemical Properties

White to off-white crystalline

Uses

4-Bromo-3-(trifluoromethyl)aniline has been used in the preparation of:

  • 2,5-dibromo-(trifluoromethyl)benzene and 2-bromo-5-iodo-(trifluoromethyl)benzene
  • AUY954, an aminocarboxylate analog of FTY720, a low nanomolar, monoselective agonist of the sphingosine-1-phosphate receptor

Synthesis

367-67-9

393-36-2

General procedure for the synthesis of 5-amino-2-bromobenzotrifluoride from 2-bromo-5-nitrobenzotrifluoride: 300 mL of methanol, 284 g of 2-bromo-5-nitrobenzotrifluoride, 20 g of Raney Ni Catalyst, and 1.0 g of piperazine were added to a 1 L high pressure hydrogenation reactor. The air in the reactor was replaced with hydrogen 3-4 times, followed by the hydrogenation reaction at a hydrogen pressure of 0.8-1.0 MPa and 80-90 °C until no more hydrogen was consumed. Upon completion of the reaction, the reaction mixture was cooled and filtered to remove the Raney Ni catalyst. Methanol and water were removed by distillation under reduced pressure, and the final product was obtained by simple distillation as a pale yellow liquid product, 5-amino-2-bromobenzotrifluoride, 250 g, with a GC purity of 95% and a yield of 98.8%.The Raney Ni catalyst and the solvent, methanol, can be recovered for reuse.

References

[1] Patent: CN106905104, 2017, A. Location in patent: Paragraph 0020; 0022
[2] Journal of the American Chemical Society, 1951, vol. 73, p. 3932

4-Bromo-3-(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-3-(trifluoromethyl)aniline Suppliers

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View Lastest Price from 4-Bromo-3-(trifluoromethyl)aniline manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
4-Bromo-3-(trifluoromethyl)aniline 393-36-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-07-01
Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Bromo-3-(trifluoromethyl)aniline 393-36-2
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-28
Hangzhou ICH Biofarm Co., Ltd
Product
4-Bromo-3-(trifluoromethyl)aniline 393-36-2
Price
US $0.00-0.00/kg
Min. Order
0.10000000149011612kg
Purity
99.0%min
Supply Ability
20000kg
Release date
2023-06-28

393-36-2, 4-Bromo-3-(trifluoromethyl)anilineRelated Search:

4-Bromo-3-(trifluoromethyl)aniline 2-Bromo-5-nitrobenzotrifluoride 4-BROMO-3-(TRIFLUOROMETHYL)ACETANILIDE 4-BROMO-2-(TRIFLUOROMETHYL)ANILINE,4-BROMO-2-(TRIFLUOROMETHYL)ANILINE 97% 4-Bromo-2-TrifluoromethylAniline/4-Bromo-2-(Trifluoromethyl)Aniline/2-Amino-5-Bromobenzotrifluoride 2-bromo-3-(trifluoromethyl)aniline 5-BROMO-2-(TRIFLUOROMETHYL)ANILINE,5-BROMO-O-(TRIFLUOROMETHYL)ANILINE 3-BROMO-5-(TRIFLUOROMETHYL)ANILINE 2-BROMO-4-(TRIFLUOROMETHYL)ANILINE 2-BROMO-5-(TRIFLUOROMETHYL)ANILINE,2-BROMO-5-(TRIFLUOROMETHYL)ANILINE/3-AMINO-4-BROMOBENZOTRIFLUORIDE/ 2-Bromobenzotrifluoride Bicalutamide 4-Bromoaniline Toluene 4-BROMO-5-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE N-(4-BROMO-5-(TRIFLUOROMETHYL)-2-NITROPHENYL)ACETAMIDE 4-BROMO-2-FLUORO-5-(TRIFLUOROMETHYL)ANILINE N-(2-AMINO-4-BROMO-5-(TRIFLUOROMETHYL)PHENYL)ACETAMIDE

  • 4-Bromo-alpha,alpha,alpha-trifluoro-m-toluidine
  • Benzenamine, 4-bromo-3-(trifluoromethyl)-
  • 5-amino-2-bromo-trifluoromethylbenzene / 4-bromo-3-trifluoromethyl-aniline
  • 4-Bromo-3-(trifluoromethyl)aniline, 4-Bromo-alpha,alpha,alpha-trifluoro-m-toluidine
  • 2-BROMO-5-AMINOBENZOTRIFLUORIDE
  • 4-BROMO-3-(TRIFLUOROMETHYL)ANILINE
  • 4-BROMO-3-TRIFLUOROMETHYL-PHENYLAMINE
  • 4-AMINO-1-BROMO-2-(TRIFLUOROMETHYL)BENZENE
  • 5-AMINO-2-BROMOBENZOTRIFLUORIDE
  • BUTTPARK 37\11-68
  • 3-trifluoromethyl-4-bromoaniline
  • 3-Trifluoromethyl-4-bromoanili
  • 5-amino-2-bromobenzotrifluoride (intermediate of bicalutamide)
  • 5-Amino-2-bromobenzotrifluoride 97%
  • 5-Amino-2-bromobenzotrifluoride97%
  • 4-bromo-3-(Trilfuoromethyl)aniline
  • 1-Bromo-2-(trifluoromethyl)-4-aminobenzene
  • 4-Bromo-3-(trifluoromethyl)benzenamine
  • 5-Amino-2-bromobenzotrifluo
  • 4-BROMO-3-(TRIFLUOROMETHYL)ANILIME
  • 4-BROMO-3-(TRIFLUOROMETHYL)ANILINE / 5-AMINO-2-BROMOBENZOTRIFLUORIDE
  • 4-BROMO-3-(TRIFLUOROMETHYL)ANILINE 98%
  • 4-Amino-1-bromo-2-(trifluoromethyl)benzene 4-Bromo-3-(trifluoromethyl)aniline
  • 4-Bromo-3-(trifluoromethyl)aniline,98%
  • 5-AMINO-2-BROMOBE
  • 4-Bromo-3-(trifluoromethyl)aniline 98%min
  • 5-Amino-2-bromobenzotrifluoride &gt
  • Amino-2-bromobenzotrifluoride
  • 4-Bromo-3-(trifluoromethyl)aniline ISO 9001：2015 REACH
  • 4-bromo-?,?,?-trifluoro-m-toluidine
  • 4-Bromo-3-(trifluoromethyl)aniline,96%
  • 4-bromo-α,α,α-trifluoro-m-toluidine
  • 393-36-2
  • 393-63-6
  • 93-36-2
  • 396-36-2
  • BrC6H3CF3NH2
  • Organic Building Blocks
  • Nitrogen Compounds
  • C7
  • Building Blocks
  • Amines
  • Miscellaneous
  • Benzotrifluoride Series
  • C7
  • Nitrogen Compounds
  • Aniline series
  • Aniline
  • Amines
  • blocks
  • Bromides
  • Building Blocks
  • Chemical Synthesis
  • Nitrogen Compounds
  • Organic Building Blocks
  • Trifluoromethylbenzene serise
  • amine| alkyl bromide
  • bc0001