2-Bromo-5-nitrobenzotrifluoride

Product Name: 2-Bromo-5-nitrobenzotrifluoride
CAS No.: 367-67-9
Chemical Name: 2-Bromo-5-nitrobenzotrifluoride
Synonyms: 2-Bromo-5-nitrobenzo;Alvocidib Impurity 32;LABOTEST-BB LT01143236;Bicalutamide Impurity 5;Bicalutamide Impurity 3;Bicalutamide Impurity 10;Bicalutamide Impurity 20;2-Bromo-5-nitrobenzotrifluorid;2-broMo-5-nitrotrifluorotoluol;2-Bromo-5-nitrobenzotrifluride
CBNumber: CB3721603
Molecular Formula: C7H3BrF3NO2
Formula Weight: 270
MOL File: 367-67-9.mol

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2-Bromo-5-nitrobenzotrifluoride Property

Melting point:: 41-44 °C (lit.)
Boiling point:: 87-88 °C/3 mmHg (lit.)
Density: 1.7750 (estimate)
Flash point:: >230 °F
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
color: White to Light yellow to Green
BRN: 2460260
Exposure limits: ACGIH: TWA 2.5 mg/m3
NIOSH: IDLH 250 mg/m3
InChI: InChI=1S/C7H3BrF3NO2/c8-6-2-1-4(12(13)14)3-5(6)7(9,10)11/h1-3H
InChIKey: SXEQQBBOAMHOID-UHFFFAOYSA-N
SMILES: C1(Br)=CC=C([N+]([O-])=O)C=C1C(F)(F)F
CAS DataBase Reference: 367-67-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 37/39-26-24/25
RIDADR: 2306
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29049090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 365769
Product name: 2-Bromo-5-nitrobenzotrifluoride
Purity: 97%
Packaging: 5g
Price: $31.2
Updated: 2023/06/20

TCI Chemical

Product number: B3686
Product name: 2-Bromo-5-nitrobenzotrifluoride
Purity: >98.0%(GC)
Packaging: 5g
Price: $24
Updated: 2025/07/31

TCI Chemical

Product number: B3686
Product name: 2-Bromo-5-nitrobenzotrifluoride
Purity: >98.0%(GC)
Packaging: 25g
Price: $95
Updated: 2025/07/31

TRC

Product number: B697970
Product name: 2-Bromo-5-nitrobenzotrifluoride
Packaging: 5g
Price: $75
Updated: 2021/12/16

Usbiological

Product number: 264248
Product name: 2-Bromo-5-nitrobenzotrifluoride
Packaging: 100g
Price: $380
Updated: 2021/12/16

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2-Bromo-5-nitrobenzotrifluoride Chemical Properties,Usage,Production

Chemical Properties

yellow crystals

Uses

2-Bromo-5-nitrobenzotrifluoride may be used in the preparation of:

new unsymmetrical diamine monomer containing both the benzimidazole ring and trifluoromethyl group, 6,4′-diamino-2′-trifluoromethyl-2-phenylbenzimidazole
2,5-bis[(4-nitro-2-trifluoromethylphenoxy)-phenyl]diphenylphosphine oxide (BNTFDPO)

Synthesis

392-83-6

367-67-9

General procedure for the synthesis of 2-bromo-5-nitrobenzotrifluoride from o-bromobenzotrifluoride: 260 g of concentrated sulfuric acid (98%) was placed in a reaction flask at room temperature, and 120 g of fuming nitric acid was added slowly to prepare a nitrification acid mixture. The temperature of the reaction system was maintained at 50-60°C, and 390g of o-bromobenzotrifluoride was slowly added to the mixed acid. After the addition was completed, the temperature was maintained and the reaction continued to be stirred until the GC test showed that the raw material was completely consumed and the reaction was completed. After the reaction solution was left to stratify, the upper organic phase was separated and washed to neutrality with alkali. A bright yellow liquid was obtained, which was immediately post-treated to finally obtain 450.4 g of 2-bromo-5-nitrobenzotrifluoride, with a GC purity of 95% and a yield of 92%.

References

[1] Patent: CN106905104, 2017, A. Location in patent: Paragraph 0020-0021
[2] Journal of the American Chemical Society, 1951, vol. 73, p. 3932

2-Bromo-5-nitrobenzotrifluoride Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-5-nitrobenzotrifluoride Suppliers

Americas 1 Belgium 3 China 282 Europe 3 France 2 Germany 6 India 18 Italy 1 Japan 3 Slovakia 1 Switzerland 2 The Netherlands 1 United Kingdom 22 United States 49 Global 394

Changzhou Chemscaler Pharmtech Co., Ltd.

Tel: 0519-81096292 15312577869
Email: chemscaler@yahoo.com.cn
Country: China
ProdList: 311
Advantage: 60

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Liaoning Tianhua Chemical Co., Ltd.

Tel: 0418-6530555 2855550
Fax: +86-418-6502885
Country: China
ProdList: 338
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Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
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TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
Email: sales@demochem.com
Country: China
ProdList: 2572
Advantage: 57

Ark Pharm, Inc.

Tel: 847-367-3680
Fax: 847-367-3681
Email: sales@arkpharminc.com
Country: United States
ProdList: 1670
Advantage: 56

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

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View Lastest Price from 2-Bromo-5-nitrobenzotrifluoride manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Bromo-5-nitrobenzotrifluoride 367-67-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-07-01

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Bromo-5-nitrobenzotrifluoride 367-67-9
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-05

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Bromo-5-nitrobenzotrifluoride 367-67-9
Price: US $0.00-0.00/KG
Min. Order: 50mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-08

367-67-9, 2-Bromo-5-nitrobenzotrifluorideRelated Search:

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Bicalutamide Impurity 3

Bicalutamide Impurity 20

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Alvocidib Impurity 32

(2RS)-N-[4-Bromo-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)-sulfonyl]-2-hydroxy-2-methylpropanam

2-Bromo-5-nitrobenzotrifluoride, 96%

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367-67-9

Building Blocks

Nitrogen Compounds

Organic Building Blocks

Nitro Compounds

ARYL HALIDE

Nitro Compounds

Nitrogen Compounds

Organic Building Blocks

Benzene series

API intermediates

Trifluoromethylbenzene serise