METHYL 4-(4-PYRIDINYL)BENZOATE

METHYL 4-(4-PYRIDINYL)BENZOATE Property

Melting point:

103-105℃

Boiling point:

160 °C(Press: 1 Torr)

Density 

1.147

storage temp. 

Inert atmosphere,Room Temperature

pka

4.98±0.10(Predicted)

Safety

HS Code 

2933399990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H320Causes eye irritation

H371May cause damage to organs

H400Very toxic to aquatic life

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

METHYL 4-(4-PYRIDINYL)BENZOATE Chemical Properties,Usage,Production

Synthesis

Step A: 4-Bromopyridine (3.0 g, 19.0 mmol), 4-methoxycarbonylphenylboronic acid (2.63 g, 14.6 mmol), Pd(PPh3)2Cl2 (0.35 g, 0.5 mmol) and sodium carbonate (6.91 g, 65.2 mmol) were dissolved in 1,2-dimethoxyethane (40 mL) under nitrogen protection. The reaction mixture was heated to 90 °C and stirred for 10 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 6:1 to 2:1) to afford methyl 4-(pyridin-4-yl)benzoate (2.7 g, yield: 86.8%) as a white solid. m/z MS (ESI): 214 [M+H]+.

References

[1] Patent: EP3190113, 2017, A1. Location in patent: Paragraph 0101
[2] Patent: TWI558709, 2016, B. Location in patent: Page/Page column 50; 51
[3] Patent: US2004/242572, 2004, A1. Location in patent: Page/Page column 73