ChemicalBook > CAS DataBase List > 2,8-Bis(trifluoromethyl)-4-quinolinol

2,8-Bis(trifluoromethyl)-4-quinolinol

Product Name: 2,8-Bis(trifluoromethyl)-4-quinolinol
CAS No.: 35853-41-9
Chemical Name: 2,8-Bis(trifluoromethyl)-4-quinolinol
Synonyms: BUTTPARK 94\04-03;Mefloquine Impurity 6;2,8-Bis(Trifluoromethyl)-4-Hyd;2,8-Bis-(trifluoromethyl)-4-quinoli;2,8-DI(TRIFLUOROMETHYL)QUINOLIN-4-OL;2,8-BIS(TRIFLUOROMETHYL)QUINOLIN-4-OL;2,8-BIS(TRIFLUOROMETHYL)-4-QUINOLINOL;2,8-Bis(trifluoromethyl)quinoline-4-ol;4-Quinolinol,2,8-bis(trifluoroMethyl)-;2,8-BIS-TRIFLUOROMETHYL-4-HYDROXYCHINOLE
CBNumber: CB7705522
Molecular Formula: C11H5F6NO
Formula Weight: 281.15
MOL File: 35853-41-9.mol

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2,8-Bis(trifluoromethyl)-4-quinolinol Property

Melting point:: 130-134 °C(lit.)
Boiling point:: 305.9±37.0 °C(Predicted)
Density: 1.4837 (estimate)
storage temp.: Inert atmosphere,Room Temperature
pka: 5.84±0.40(Predicted)
form: Liquid
color: Clear colorless to slightly yellow
InChI: InChI=1S/C11H5F6NO/c12-10(13,14)6-3-1-2-5-7(19)4-8(11(15,16)17)18-9(5)6/h1-4H,(H,18,19)
InChIKey: JIWHKBAFGFPZKM-UHFFFAOYSA-N
SMILES: N1C2C(=CC=CC=2C(F)(F)F)C(O)=CC=1C(F)(F)F
CAS DataBase Reference: 35853-41-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
RIDADR: 2811
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29334900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B3714
Product name: 2,8-Bis(trifluoromethyl)-4-hydroxyquinoline
Purity: >98.0%(GC)
Packaging: 1g
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: B3714
Product name: 2,8-Bis(trifluoromethyl)-4-hydroxyquinoline
Purity: >98.0%(GC)
Packaging: 5g
Price: $109
Updated: 2022/04/27

TRC

Product number: T790673
Product name: 2,8-Bis(trifluoromethyl)-4-hydroxyquinoline
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: T790673
Product name: 2,8-Bis(trifluoromethyl)-4-hydroxyquinoline
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: PC9017
Product name: 2,8-Bis(trifluoromethyl)-4-hydroxyquinoline
Purity: 97%
Packaging: 25g
Price: $82
Updated: 2021/12/16

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2,8-Bis(trifluoromethyl)-4-quinolinol Chemical Properties,Usage,Production

Chemical Properties

light grey powder

Synthesis

372-31-6

88-17-5

35853-41-9

2-(Trifluoromethyl)aniline (0.54 mL, 4.3 mmol) and ethyl 4,4,4-trifluoro-3-oxobutanoate (0.62 mL, 4.3 mmol) were mixed in a round-bottomed flask fitted with a large oval stir bar. Subsequently, polyphosphoric acid (4.0 g) was added to the reaction system. The reaction mixture was stirred at 120 °C for 3 h under nitrogen protection. Upon completion of the reaction, the reaction was quenched with ice water (50 mL) to give a golden-brown sticky substance. Extraction was carried out with dichloromethane (2 x 20 mL) and the organic layers were combined and dried over anhydrous magnesium sulfate. After filtration, the organic phase was concentrated under reduced pressure to give a beige solid product that did not require further purification (0.27 g, 23% yield).

References

[1] European Journal of Medicinal Chemistry, 2010, vol. 45, # 8, p. 3374 - 3383
[2] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 2012, vol. 51, # 9, p. 1411 - 1416,6
[3] Monatshefte fur Chemie, 2008, vol. 139, # 2, p. 179 - 181
[4] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 23, p. 5466 - 5469
[5] CrystEngComm, 2018, vol. 20, # 16, p. 2316 - 2323

2,8-Bis(trifluoromethyl)-4-quinolinol Preparation Products And Raw materials

Raw materials

Preparation Products

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2,8-Bis(trifluoromethyl)-4-quinolinol Suppliers

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View Lastest Price from 2,8-Bis(trifluoromethyl)-4-quinolinol manufacturers

Career Henan Chemical Co

Product: 2,8-Bis(trifluoromethyl)-4-quinolinol 35853-41-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-25

35853-41-9, 2,8-Bis(trifluoromethyl)-4-quinolinolRelated Search:

2-(Trifluoromethyl)benzyl chloride 4-Hydroxyquinoline Quinhydrone 2-(Trifluoromethyl)benzoic acid 3-(Trifluoromethyl)benzaldehyde 3-Aminobenzotrifluoride Trifluoromethanesulfonic acid (Trifluoromethyl)trimethylsilane 2-Methylbenzotrifluoride 8-Methylquinoline 4-HYDROXY-2-METHYLQUINOLINE 2-(Trifluoromethyl)pyridine 8-(TRIFLUOROMETHYL)QUINOLIN-4-OL 2,8-Dimethylquinoline 2,8-DIMETHYL-4-HYDROXYQUINOLINE 8-Trifluoromethylquinoline 4-HYDROXY-8-METHYL-2-(TRIFLUOROMETHYL)QUINOLINE 2,6-BIS(TRIFLUOROMETHYL)-4-HYDROXYQUINOLINE

BUTTPARK 94\04-03

2,8-DI(TRIFLUOROMETHYL)QUINOLIN-4-OL

2,8-BIS(TRIFLUOROMETHYL)-4-QUINOLINOL

2,8-BIS(TRIFLUOROMETHYL)QUINOLIN-4-OL

2,8-BIS-TRIFLUOROMETHYL-4-HYDROXYCHINOLE

2,8-BIS TRIFLUOROMETHYL-4-HYDROXY QUINOLEINE

2,8-BIS(TRIFLUOROMETHYL)-4-HYDROXYQUINOLINE

2,8-Bis(Trifluoromethyl)-4-Hyd

2,8-Bis(trifluoromethyl)-4-hydroxyquinoline 97%

2,8-Bis(trifluoromethyl)-4-hydroxyquinoline97%

2,8-BIS(TRIFLUOROMETHYL)-4-QUINOLINOL 99%

2,8-Bis(trifluoromrthyl)-4-hydroxyquinoline

2,8-Bis(trifluoromethyl)quinoline-4-ol

2,8-Bis(trifluoromethyl)-4-quinolinol,99%

2,8-Bis(trifluoroMethyl)-4-quinolinol, 99% 1GR

4-Quinolinol,2,8-bis(trifluoroMethyl)-

2,8- double(three fluoroMethyl)-4- hydroxyquinoline

2,8-bis(trifluoromethyl)-1H-quinolin-4-one

2,8-Bis(trifluoromethyl)quinolin-4-ol, 2,8-Bis(trifluoromethyl)-4-hydroxy-1-azanaphthalene

2,8-Bis(trifluoroMethyl)-4-hydroxyquoline

2,8-Bis-(trifluoromethyl)-4-quinoli

2,8-Bis(trifluoromethyl)-4-hydroxyquinoline &gt

2,8-Bis(trifluoromethyl)-4-quinolinol ISO 9001：2015 REACH

Mefloquine Impurity 6

(1RS,3SR,8aSR)-1,3-Bis[2,8-bis(trifluoromethyl)-4-quinolyl]-3,5,6,7,8,8a-hexahydro-1H-oxazolo[3,4-a

35853-41-9

Strontium Ranelate

Quinoline&Isoquinoline

API intermediates