ChemicalBook > CAS DataBase List > N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide

N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide

Product Name
N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide
CAS No.
77377-52-7
Chemical Name
N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide
Synonyms
DK398;tbstfa;MTBSTFA;MBDSTFA;DKFELEX0083;MTBSTFA=TBSTFA;MTBSTFA AND TBDMCS;DEUTERO-REGISIL-D18;MTBSTFA AND TBDMSCL;N-(tert-Butyldimethy
CBNumber
CB7707814
Molecular Formula
C9H18F3NOSi
Formula Weight
241.33
MOL File
77377-52-7.mol
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N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide Property

Boiling point:
172-175 °C(lit.)
Density 
1.036 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.402(lit.)
Flash point:
127 °F
storage temp. 
2-8°C
solubility 
sol most aprotic organic solvents.
pka
-1.50±0.70(Predicted)
form 
Liquid
Specific Gravity
1.023
color 
Clear colorless to slightly yellow
Water Solubility 
decomposes
Sensitive 
Moisture Sensitive
Hydrolytic Sensitivity
8: reacts rapidly with moisture, water, protic solvents
BRN 
3606546
CAS DataBase Reference
77377-52-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,F
Risk Statements 
10-36/37/38
Safety Statements 
26-36-16-37/39-36/37/39
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
F 
10-21
Hazard Note 
Flammable
TSCA 
No
HS Code 
2931 90 00
HazardClass 
3
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.14219
Product name
N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide
Purity
for synthesis
Packaging
1mL
Price
$65.3
Updated
2024/03/01
Sigma-Aldrich
Product number
M-108
Product name
MTBSTFA (with 1% t-BDMCS)
Purity
ampule of 5 × 1?mL, (with 1% t-BDMCS), analytical standard, Cerilliant?
Packaging
5x1mL
Price
$74.4
Updated
2024/03/01
Sigma-Aldrich
Product number
8.14219
Product name
N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide
Purity
for synthesis
Packaging
5ml
Price
$206
Updated
2024/03/01
Sigma-Aldrich
Product number
77626
Product name
N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide
Purity
for GC derivatization, LiChropur?, ≥99.0% (GC)
Packaging
10ml
Price
$271
Updated
2024/03/01
Sigma-Aldrich
Product number
77626
Product name
N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide
Purity
for GC derivatization, LiChropur?, ≥99.0% (GC)
Packaging
10X1ML
Price
$352
Updated
2024/03/01
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N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide Chemical Properties,Usage,Production

Chemical Properties

clear colorless to slightly yellow liquid

Physical properties

bp 168–170°C; d 1.12 g cm?3.

Uses

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide with 1% tert-butyldimethylchlorosilane is commonly used for the preparation of N-tert-butyldimethylsilyl ethanolamines resulting from the hydrolysis of nitrogen mustards. It is also used for selective O-silylation of N,O-diacylhydroxyl amines.

Uses

In the presence of 1% of t-butyldimethylchlorosilane as the catalyst, N-(t-butyldimethylsilyl)-N-methyltrifluoroacetamide (BSMTFA) functions as an extremely reactive t-butyldimethylsilylating reagent for alcohols, amines, carboxylic acids, and thiols. Silylation is generally completed within 5 min at 25°C in acetonitrile. This amide is more reactive than N-(t-butyldimethylsilyl)-N-methylacetamide.
In the protection of a hydroxy group, the resultant tbutyldimethylsilyl (TBDMS) ethers are stable under the conditions for acetate saponification and hydrogenation.These silyl ethers also remain intact towards the Jones reagent and Wittig reagents. The TBDMS ethers are approx. 10 times more stable against hydrolysis than the corresponding trimethylsilyl (TMS) ethers.Selective removal of the TBDMS group can be accomplished by use of dilute acetic acid or tetra-n-butylammonium fluoride in THF at 25°C.
Silylation of ketones by use ofBSMTFAoccurs in triethylamine and DMF at 40–60°C to give the corresponding silyl enol ethers in good to excellent yields (eq 1).In addition, silyl ether formation takes place in N-hydroxysuccinimide (88% yield) and Nhydroxypyrrole (99% yield) by use of BSMTFA in THF.

Uses

N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide is a silylating agent used in the derivatization of various organic compounds (such as amino acids) for gas chromatogography-mass spectrometry (GC-MS) analysis.

Preparation

obtained in 91% yield by reaction of N-methyl-2,2,2-trifluoroacetamide (1.0 equiv) in benzene and acetonitrile (1:1 v/v) with NaH (1.0 equiv) and then with t-BuMe2SiCl (1.2 equiv) at 4°C.

Definition

ChEBI: An N-silyl compound that is N-methyltrifluoroacetamide in which the amide nitrogen is replaced by a tert-butyldimethylsilyl group.

General Description

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide is a silylating reagent which replaces the active hydrogen with tert-Butyldimethylsilyl group. The tert-Butyldimethylsilyl derivatives are found to be more resistant to hydrolysis and stable compared to trimethylsilyl (TMS) derivatives. This reagent is suitable for GC-MS analysis since it produces mass spectra, which can be easily interpreted. It is widely used for the silylation of different alcohols, thiols, phenols, carboxylic acids, amines, and amides.

N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide Suppliers

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View Lastest Price from N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide manufacturers

Hebei Mojin Biotechnology Co.,Ltd
Product
N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide 77377-52-7
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000KG/month
Release date
2024-08-08
Career Henan Chemical Co
Product
N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide 77377-52-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000KGS
Release date
2020-01-02

77377-52-7, N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamideRelated Search:

METSULFURON METHYL Basic Violet 1 Trifluoroacetamide N-Methylacetamide N,N-Dimethylformamide N,N-Dimethylacetamide Methyl acrylate Tribenuron methyl POLYDIMETHYLSILOXANE Kresoxim-methyl Methylparaben Dimethyl sulfoxide Methyl salicylate Dimethyl sulfone Methanol Poly(dimethylsiloxane) tert-Butyldimethylsilyl chloride Methyl

  • MBDSTFA
  • DEUTERO-REGISIL-D18
  • N-TERT-BUTYLDIME.SILYL-N-ME.TRIFLUOROACE
  • N-TERT-BUTYLDIME.SILYL-N-ME.TRIFLUOROACE TAMIDE + 1% TBDMSCL
  • N-(TERT-BUTYLDIMETHYLSILYL)-N-METHYL-TRI FLUOROACETAMIDE, 97+%
  • N-(TERT-BUTYLDIMETHYLSILYL)-N-METHYLTRIF LUOROACETA
  • N-(TERT-BUTYLDIMETHYLSILYL)-N-METHYL-TRIFLUOROACETAMIDE, W/1% TBDMSCL, >=95%
  • N-TERT-BUTYLDIMETHYLSILYL-N-METHYL TRIFL
  • MTBSTFA=TBSTFA
  • SILYLATING MIXTURE FLUKA VI
  • MTBSTFA
  • MTBSTFA AND TBDMCS
  • MTBSTFA AND TBDMSCL
  • N-METHYL(TERT-BUTYLDIMETHYLSILYL)TRIFLUOROACETAMIDE
  • N-METHYL-N-(T-BUTYLDIMETHYLSILYL)TRIFLUOROACETAMIDE
  • N-METHYL-N-TERT-BUTYLDIMETHYLSILYLTRIFLUOROACETAMIDE
  • N-METHYL-N-[TERT-BUTYLDIMETHYL-SILYL]TRIFLUOROACETAMIDE AND TERT-BUTYLDIMETHYLCHLOROSILANE
  • N-(T-BUTYLDIMETHYLSILYL)-N-METHYLTRIFLUOROACETAMIDE
  • N-(TERT-BUTYLDIMETHYLSILYL)-N-METHYLTRIFLUORACETAMIDE
  • N-(TERT-BUTYLDIMETHYLSILYL)-N-METHYLTRIFLUOROACETAMIDE
  • MTBSTFA + 1% TBDMSCl, MTBSTFA+TBDMSCl, 99:1, Silylating mixture Fluka VI, N-Methyl-N-tert-butyldimethylsilyltrifluoroacetamide
  • MTBSTFA + 1% TBDMSCl, Silylating mixture Fluka VI, N-Methyl-N-tert-butyldimethylsilyltrifluoroacetamide
  • Acetamide, N-(1,1-dimethylethyl)dimethylsilyl-2,2,2-trifluoro-N-methyl-
  • N-(tert-B-butyldimethylsilyl)-n-methyl- trifluoroacetamide, 98%
  • N-Methyl-N-(tert-butyldimethylsilyl)-2,2,2-trifluoroacetamide
  • N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide,98%
  • N-Methyl-N-[Tert-Butyld
  • N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide with 1% tert-Butyldimethylchlorosilane,N-Methyl-N-tert-butyldimethylsilyltrifluoroacetamide, MTBSTFA + 1% TBDMSCl, MTBSTFA+TBDMSCl, 99:1, Silylatin
  • N-(tert-Butyldimethy
  • MTBSTFA (with 1% t-BDMCS)
  • N-[(tert-Butyl)dimethylsilyl]-N-methyl-2,2,2-trifluoroacetamide, [Methyl(trifluoroacetyl)amino]dimethylsilane
  • [tert-butyl-(2,2,2-trifluoro-1-oxoethyl)amino]methyl-dimethylsilicon
  • MTBSTFA + 1% TBDMSCl
  • MTBSTFA (N-(tert-butyldiMethylsilyl)-N-METHYLTRIFLUOROACETAMIDE)
  • MTBSTFA /1% tert-butyldiMethylchlorosilane
  • N-tert-ButyldiMethylsilyl-N-MethyltrifluoroacetaMide with 1% tert-ButyldiMethylchlorosilane >=95%
  • n-tert-butyldimethylsilyl-n-methyltrifluoroacetamide with 1% tert-butyldimethylchlorosilane
  • tbstfa
  • N-Methyl-(tert-Butydimethylsilyl)-trifluoroacetamide
  • N-Methyl(tert-butyldimethylsilyl)trifluoroacetamide 95%
  • N-Methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide 99+%
  • N-Methyl(tert-butyldimethylsilyl)trifluoroacetamide95%
  • N-Methyl-N-(tert-butyldimethylsilyl)trifluoro-
  • N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide (MTBSTFA)
  • MTBSTFA+TBDMSCl, 99:1
  • N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide >=97.0% (GC)
  • N-[(1,1-DiMethylethyl)diMethylsilyl]-2,2,2-trifluoro-N-MethylacetaMide
  • N-Methyl-N-(tert-butyldiMethylsilyl)-1,1,1-trifluoroacetaMide
  • N-Methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide MTBSTFA
  • N-TERT-BUTYLDIMETHYLSILYL-N-METHYLTRIFLU
  • N-[(tert-Butyl)dimethylsilyl]-N-methyltrifluoroacetamide 97%
  • N-(tert-ButyldiMethylsilyl)-N-Methyl-trifluoroacetaMide, 98% 1GR
  • N-(t-butyldiMethylsilyl)-N-MethyltrifluoroacetaMide with N-(t-butlydiMethylsilylchloride)
  • N-[tert-butyl(dimethyl)silyl]-2,2,2-trifluoro-N-methylacetamide
  • N-(t-Butyldimethylsilyl)-N-methyltrifluoroacetamid
  • N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide &gt
  • N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide (Technical Grade)
  • DK398