N-Nitrosodiphenylamine
Health effects- Product Name
- N-Nitrosodiphenylamine
- CAS No.
- 86-30-6
- Chemical Name
- N-Nitrosodiphenylamine
- Synonyms
- Ndpa;NdphA;Nitrosodiphenylamine;TJB;Redax;delacj;Ortard;Sconoc;Delac J;Vultrol
- CBNumber
- CB7712443
- Molecular Formula
- C12H10N2O
- Formula Weight
- 198.22
- MOL File
- 86-30-6.mol
N-Nitrosodiphenylamine Property
- Melting point:
- 65-66 °C
- Boiling point:
- 268°C
- Density
- 1.23
- vapor pressure
- 0.1 at 25 °C (assigned by analogy, Mabey et al., 1982)
- refractive index
- 1.6330 (estimate)
- Flash point:
- 11 °C
- storage temp.
- 2-8°C
- solubility
- methanol: 0.1 g/mL, clear
- pka
- -5.83±0.50(Predicted)
- form
- Yellow to brown or orange powder or flakes
- color
- Yellow to brown to orange power or flakes
- Water Solubility
- Insoluble
- BRN
- 909531
- Henry's Law Constant
- 2.33 at 25 °C (approximate - calculated from water solubility and vapor pressure)
- Stability:
- Stability Combustible. Incompatible with oxidising agents.
- LogP
- 3.13 at 25℃
- CAS DataBase Reference
- 86-30-6(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzenamine, N-nitroso-N-phenyl-(86-30-6)
- IARC
- 3 (Vol. 27, Sup 7) 1987
- EPA Substance Registry System
- N-Nitrosodiphenylamine (86-30-6)
Safety
- Hazard Codes
- Xn,T,F
- Risk Statements
- 22-39/23/24/25-23/24/25-11
- Safety Statements
- 22-36/37-53-45-16-7
- RIDADR
- UN 1230 3/PG 2
- WGK Germany
- 3
- RTECS
- JJ9800000
- F
- 4.10-9-23
- HS Code
- 2921.44.0500
- HazardClass
- 9
- PackingGroup
- III
- Hazardous Substances Data
- 86-30-6(Hazardous Substances Data)
- Toxicity
- Acute oral LD50 for mice 3,850 mg/kg, rats 1,650 mg/kg (quoted, RTECS, 1985).
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H301Toxic if swalloed
H302Harmful if swallowed
H311Toxic in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H320Causes eye irritation
H331Toxic if inhaled
H341Suspected of causing genetic defects
H351Suspected of causing cancer
H370Causes damage to organs
H371May cause damage to organs
H373May cause damage to organs through prolonged or repeated exposure
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P311Call a POISON CENTER or doctor/physician.
P391Collect spillage. Hazardous to the aquatic environment
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 40060
- Product name
- N-Nitrosodiphenylamine solution
- Purity
- certified reference material, 5000?μg/mL in methanol
- Packaging
- 1ML
- Price
- $62.3
- Updated
- 2024/03/01
- Product number
- D0899
- Product name
- N-Nitrosodiphenylamine
- Purity
- >98.0%(HPLC)
- Packaging
- 25g
- Price
- $28
- Updated
- 2024/03/01
- Product number
- D0899
- Product name
- N-Nitrosodiphenylamine
- Purity
- >98.0%(HPLC)
- Packaging
- 500g
- Price
- $222
- Updated
- 2024/03/01
- Product number
- N525775
- Product name
- N-Nitrosodiphenylamine
- Packaging
- 5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- CHM0014747
- Product name
- N-NITROSO DIPHENYLAMINE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $679.14
- Updated
- 2021/12/16
N-Nitrosodiphenylamine Chemical Properties,Usage,Production
Health effects
N-nitrosodiphenylamine is classified by the Environmental Protection Agency (EPA) as a probable human carcinogen. This is based on increased bladder tumors in male and female rats, an increase in reticulum cell sarcomas (a form of malignant lymphoma) in mice, and the chemical’s structural similarity to nitrosamines (known carcinogens). Animal studies involving chronic exposure to high levels of N-nitrosodiphenylamine resulted in cancer of the bladder and changes in body weight. The EPA considers N-nitrosodiphenylamine a hazardous waste, and spills exceeding 100 pounds must immediately be reported. Being exposed to N-nitrosodiphenylamine over a long period can cause cancer in animals, including bladder cancer and lymphoma, and may cause cancer in humans.
Chemical Properties
N-Nitrosodiphenylamine is a yellow to orangebrown crystalline solid. Soluble in acetone, benzene, ethyl acetate, dichloromethane, carbon tetrachloride, ether and carbon disulfide, soluble in hot alcohol, slightly soluble in gasoline, insoluble in water. In the hydrochloric acid methanol solution, a shift reaction can occur, and it can be transformed into p-nitrosodiphenylamine.
Uses
N-Nitrosodiphenylamine is the N-nitroso analogue of diphenylamine that was once used as a rubber additive but is no longer due to undesirable carcinogenic effects (1). N-Nitrosodiphenylamine may have potential carcinogenic activity and is currently classified as a probable carcinogen by EPA with genetic toxicity (2,3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
Definition
ChEBI: N-Nitrosodiphenylamine is a member of phenylhydrazines. It is an industrial compound that formerly used as a vulcanization retarder in the rubber industry.
General Description
N-nitrosodiphenylamine appears as yellow to brown or orange powder or flakes or a black solid. Insoluble in water and denser in water. Hence sinks in water. (NTP, 1992)
Air & Water Reactions
Insoluble in water.
Reactivity Profile
N-Nitrosodiphenylamine may be sensitive to moisture at elevated temperatures in strongly acidic solutions. May react vigorously with oxidizing agents. May undergo trans-nitrosation reactions with secondary amines .
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition N-Nitrosodiphenylamine emits toxic fumes of nitrogen oxides.
Fire Hazard
Flash point data for N-Nitrosodiphenylamine are not available; however, N-Nitrosodiphenylamine is probably combustible.
Flammability and Explosibility
Non flammable
Safety Profile
Moderately toxic by ingestion. An eye irritant. Questionable carcinogen with experimental carcinogenic and tumorigenic data. Human mutation data reported. Dangerous fire hazard when exposed to heat, flame, or oxidzing materials. Can react vigorously with oxidizing materials. When heated to decomposition it emits highly toxic fumes of NOx,. See also NITROSAMINES.
Potential Exposure
N-Nitrosodiphenylamine is not a naturally occurring substance; it is a man-made chemical that is no longer produced in the United States. It was used in the manufacture of plastics, resins, rubber and synthetic textiles; to help control processes involved in making rubber products, such as tires and mechanical goods; however, in the early 1980s, the United States manufacturers stopped producing N-nitrosodiphenylamine because new and more efficient chemicals were found to replace its uses. In addition, the use of N-nitrosodiphenylamine had several undesirable side effects which do not occur with the replacement chemicals.
Carcinogenicity
Two feeding experiments with NDPhA in rats were totally negative (no tumors). One used daily doses of 120 mg/kg body weight to a total dose of 65 g/kg, and another used a lower dose for only 53 weeks. Another experiment involved larger groups of rats and mice and higher doses. In mice, after 2 years, there was occasional hyperplasia of the bladder mucosa, but no tumors; in rats given 4000 mg NDPhA/kg diet for 2 years, 16/45 males and 40/49 females had transitional cell carcinomas of the bladder. IARC classified NDPhA as not classifiable as to carcinogenicity in humans (Group 3).
Environmental Fate
Chemical/Physical. At temperatures greater than 85 °C, technical grades may decompose to
nitrogen oxides (IARC, 1978). N-Nitrosodiphenylamine will not hydrolyze because it does not
contain a hydrolyzable functional group (Kollig, 1993).
At influent concentrations of 10, 1.0, 0.1, and 0.01 mg/L, the GAC adsorption capacities were 510,
120, 91, and 38 mg/g, respectively (Dobbs and Cohen, 1980).
Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Contact with reducing agents may form hydrazine; hydrogen bromide. Light sensitive; rapidly decomposes.
Waste Disposal
Burn in admixture with flammable solvent in furnace equipped with afterburner and scrubber.
References
[1] Peng, Xiuying et al. “Electrochemical sensor for facile detection of trace N-nitrosodiphenylamine based on poly(diallyldimethylammonium chloride)-stabilized graphene/platinum nanoparticles.” New Journal of Chemistry 2 (2018): 820–826.
N-Nitrosodiphenylamine Preparation Products And Raw materials
Raw materials
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View Lastest Price from N-Nitrosodiphenylamine manufacturers
- Product
- N-Nitrosodiphenylamine 86-30-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 200kg
- Release date
- 2019-08-30