ChemicalBook > CAS DataBase List > Actarit

Actarit

Product Name: Actarit
CAS No.: 18699-02-0
Chemical Name: Actarit
Synonyms: Orcl;ms932;Mover;FAM79A;TPRG1L;ACTARIT;Ake him;Aktalin;Mirabegron M9;Protein FAM79A
CBNumber: CB7732469
Molecular Formula: C10H11NO3
Formula Weight: 193.2
MOL File: 18699-02-0.mol

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Actarit Property

Melting point:: 173-175°C
Boiling point:: 449.1±28.0 °C(Predicted)
Density: 1.288±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO, Ethanol, Methanol
form: Solid
pka: 4.34±0.10(Predicted)
color: White to Off-White
Merck: 14,133
CAS DataBase Reference: 18699-02-0(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
RTECS: CY1542000
HS Code: 29163990
Toxicity: LD50 in male, female mice, male, female rats (mg/kg): 1.06, 1.30, 1.95, 2.03 i.p.; 5.68, 5.48, 5.48, 6.12 s.c.; 15.3, 14.7, 14.8, 15.4 orally (Toshida)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2793
Product name: Actarit
Purity: >97.0%(GC)
Packaging: 100mg
Price: $27
Updated: 2025/07/31

Cayman Chemical

Product number: 20852
Product name: Actarit
Purity: ≥98%
Packaging: 5g
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 20852
Product name: Actarit
Purity: ≥98%
Packaging: 10g
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 20852
Product name: Actarit
Purity: ≥98%
Packaging: 25g
Price: $185
Updated: 2024/03/01

Cayman Chemical

Product number: 20852
Product name: Actarit
Purity: ≥98%
Packaging: 50g
Price: $302
Updated: 2024/03/01

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Actarit Chemical Properties,Usage,Production

Description

Actarit is an orally administered disease-modifying antirheumatic drug launched in Japan. Although its structure resembles that of non-steroidal anti-inflammatory drugs, it has no effect on experimental acute inflammation and has no analgesic or antipyretic effects. Its preventative and therapeutic effects on adjuvant arthritis are mediated via modulation of production and serum level of interleukin-2 which enhances production of suppressor T-cells to the immune system, thereby, preventing development of articular lesions.

Chemical Properties

Crystalline Solid

Originator

Nippon Shlnyaku;Mltaublshl Kasel (Japan)

Uses

Antiarthritic

Uses

Chronic rheumatoid arthritis

Definition

ChEBI: Actarit is an anilide and a member of acetamides.

brand name

Orcl; Mover

Synthesis

1197-55-3

108-24-7

18699-02-0

General procedure: 1.02 mmol of p-aminophenylacetic acid (Wako Pure Pharmaceutical Industries, Ltd.) was dissolved in 50 mL of a solvent mixture of dichloromethane-methanol-water (1:3:1, v/v). Under ice bath cooling conditions, 2.12 mmol of acetic anhydride was slowly added. The reaction mixture was gradually brought to room temperature with stirring and continued to stir overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to give 196.4 mg of 2-(4-acetylaminophenyl)acetic acid in 99% yield. The structure of the product was confirmed by 1H-NMR (500 MHz, CD3OD): δ 2.11 (3H, s, Ac), 3.55 (2H, s, Ph-CH2-), 7.21-7.49 (4H, m, aromatic H).

Purification Methods

Crystallise the acid from MeOH/Me2CO, aqueous EtOH or H2O. The amide has m 231o (from 50% aqueous EtOH). [Gabriel Chem Ber 15 841 1882, Cerecedo et al. J Biol Chem 42 238 1924, Tramontano et al. J Am Chem Soc 110 2282 1988, Beilstein 14 II 281.]

References

[1] Patent: EP3363463, 2018, A2. Location in patent: Paragraph 0148
[2] Asian Journal of Chemistry, 2012, vol. 24, # 4, p. 1538 - 1540
[3] Journal of the American Chemical Society, 1988, vol. 110, # 7, p. 2282 - 2286
[4] Journal of the American Chemical Society, 2009, vol. 131, p. 456 - 457
[5] Patent: WO2015/145371, 2015, A1. Location in patent: Page/Page column 40

Actarit Preparation Products And Raw materials

Raw materials

Preparation Products

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Actarit Suppliers

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View Lastest Price from Actarit manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Actarit 18699-02-0
Price: US $13.50/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000tons
Release date: 2021-12-28

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Actarit 18699-02-0
Price: US $16.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 69KG
Release date: 2022-01-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Actarit 18699-02-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

18699-02-0, ActaritRelated Search:

Acetaminophen 4-Hydroxyphenylacetic acid 4-Methoxyphenylacetic acid 2-Hydroxyphenylacetic acid ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID dexindoprofen 7-Diethylamino-3-(4'-maleimidylphenyl)-4- methylcoumarin Phenylacetic acid Indobufen 4-Aminophenylacetic acid PKSI 527 7-Diethylamino-3-[4-(iodoacetamido)phenyl]-4-methylcoumarin (4-[(3-METHYL-FURAN-2-CARBONYL)-AMINO]-PHENYL)-ACETIC ACID Actarit-d4 Desacetyl Actarit-d4 Actarit ASISCHEM D13241 N-(3-METHYL-4-(2-OXO-2H-CHROMEN-3-YL)PHENYL)-2-(O-TOLYLOXY)ACETAMIDE

4-(acetylamino)-benzeneacetic acid

[4-(ACETYLAMINO)PHENYL]ACETIC ACID

(p-acetamidophenyl)-aceticaci

(p-acetamidophenyl)aceticacid

4-(acetylamino)-benzeneaceticaci

4-n-acetylaminophenylaceticacid

ms932

RARECHEM AL BO 1520

4-ACETAMIDO-PHENYLACETIC ACID

ACTARIT

Mover

Orcl

ANTI-TPRGL (N-TERM) antibody produced in rabbit

FAM79A

Mossy fiber terminal-associated vertebrate-specific presynaptic protein

Protein FAM79A

TPRG1L

Tumor protein p63-regulated gene 1-like protein

Mirabegron M9 (YM-340790)

4-Acetamido-phenylacetic acid ,97%

O-(Carboxymethyl)paracetamol

p-Acetylaminophenylacetic acid

N-acetyl-4-aMinophenyl-acetic acid

ActaritIn-houseStandard

AKETALI (ACTARIT)

Mirabegron M9

Benzeneaceticacid, 4-(acetylamino)-

2-(4-acetamidocyclohexyl)acetate

Actarit USP/EP/BP

Mirabegron-metabolite M9

Ake him

2-(4-acetamidophenyl)aceticaci

Aktalin

Actarit, 10 mM in DMSO

18699-02-0

Aromatic Phenylacetic Acids and Derivatives

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals