ChemicalBook > CAS DataBase List > 2H-1,3-Benzoxazine-2,4(3H)-dione

2H-1,3-Benzoxazine-2,4(3H)-dione

Product Name: 2H-1,3-Benzoxazine-2,4(3H)-dione
CAS No.: 2037-95-8
Chemical Name: 2H-1,3-Benzoxazine-2,4(3H)-dione
Synonyms: ruhmal;Casalen;Caxaran;Kasaron;carsalam;beaprine;Cacharon;Carsalame;Two ketone;4(3 H)-DIONE
CBNumber: CB7736467
Molecular Formula: C8H5NO3
Formula Weight: 163.13
MOL File: 2037-95-8.mol

Less

2H-1,3-Benzoxazine-2,4(3H)-dione Property

Melting point:: 228-232 °C(lit.)
Density: 1.402±0.06 g/cm3(Predicted)
vapor pressure: 0.73-1.27Pa at 89.94-107.94℃
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO : ≥ 40 mg/mL (245.20 mM)
form: Solid
pka: 9.16±0.20(Predicted)
color: White to off-white
Merck: 13,1879
InChI: InChI=1S/C8H5NO3/c10-7-5-3-1-2-4-6(5)12-8(11)9-7/h1-4H,(H,9,10,11)
InChIKey: OAYRYNVEFFWSHK-UHFFFAOYSA-N
SMILES: O1C2=CC=CC=C2C(=O)NC1=O
LogP: 0.78-0.88 at 20℃

Less

Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36
WGK Germany: 3
RTECS: DM3110000
HS Code: 2934999090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: B6742
Product name: 2H-Benzo[e][1,3]oxazine-2,4(3H)-dione
Packaging: 25G
Price: $106
Updated: 2025/07/31

TCI Chemical

Product number: B6742
Product name: 2H-Benzo[e][1,3]oxazine-2,4(3H)-dione
Packaging: 100G
Price: $267
Updated: 2025/07/31

TRC

Product number: C184748
Product name: Carsalam
Packaging: 10g
Price: $85
Updated: 2021/12/16

ApexBio Technology

Product number: C6933
Product name: Carsalam
Packaging: 200mg
Price: $85
Updated: 2021/12/16

Apolloscientific

Product number: OR941085
Product name: 2H-Benzo[e][1,3]oxazine-2,4(3H)-dione
Purity: 95%
Packaging: 25g
Price: $90
Updated: 2021/12/16

Less

2H-1,3-Benzoxazine-2,4(3H)-dione Chemical Properties,Usage,Production

Chemical Properties

Off-white to light brown crystalline powder

Uses

analgesic

Definition

ChEBI: Carsalam is a benzoxazine.

General Description

Kinetic studies of the alkaline hydrolysis of 2H-1,3-benzoxazine-2,4(3H)-dione (carsalam) were conducted and reaction was found to be of fractional order with respect to [OH^-].

Synthesis

2H-1,3-Benzoxazine-2,4(3H)-dione was prepared according to the procedure of Hoback, Crum and Carroll. To a solution of 411 g. (3. 0 moles) salicylamide in 483 ml. (6.0 moles) of anhydrous pyridine at 0℃ was added slowly with stirring 572 ml. (6.0 moles) of ethyl chlorocarbonate. The resulting orange solution was refluxed for 5 hr. and poured into 2L of ice water. The filtered product was washed twice with 0.5L of water and recrystallized three times from acetone-ethanol (50: 50), giving white needles 2H-1,3-Benzoxazine-2,4(3H)-dione (83% yield), m.p. 227.5-228.5° (lit. 12), m.p. 227-228°, which gave no coloration with ethanolic ferric chloride[1].

References

[1] J. D. Crum, J. A. Franks Jr. “The chemistry of heterocycles. III. 2H-1,3-benzoxazine-2,4(3H)-dione and Some 3-substituted derivatives.??.” Journal of Heterocyclic Chemistry 2 1 (1965): 37–40.

2H-1,3-Benzoxazine-2,4(3H)-dione Preparation Products And Raw materials

Raw materials

Preparation Products

Less

2H-1,3-Benzoxazine-2,4(3H)-dione Suppliers

Belgium 1 China 211 Germany 1 India 4 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 2 United States 22 Global 245

Gansu Haotian PharmaTech Co.,Ltd.

Tel: 17789447501
Email: zhuanxiajiang@haotianpharm.com
Country: China
ProdList: 202
Advantage: 58

Anhui Beirui Pharmaceutical Technology Co., Ltd

Tel: 0551-68665055 18130089676
Email: ahbrchem@163.com
Country: China
ProdList: 18
Advantage: 58

Hangzhou Xinbaisi Biomedical Co., Ltd.

Tel: 13325818654
Fax: 057188737015
Email: zhsj@synbestech.com
Country: China
ProdList: 249
Advantage: 58

Hangzhou Read Chemical Co., Ltd

Tel: 15306818081 15372061639;
Fax: 0571-87234255
Email: sales@freemindpharm.com
Country: China
ProdList: 56
Advantage: 58

Abydos Scientific

Tel: 025-84767922 18936879710
Email: sales@abydoscientific.com
Country: China
ProdList: 1002
Advantage: 58

Nanjing Lynsci Chemical Co., Ltd

Tel: +86-025-83208253 +86-13851694729
Fax: 0086-25-83208253
Email: layefe@163.com
Country: China
ProdList: 231
Advantage: 62

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9309
Advantage: 66

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527621225
Email: 1791901229@qq.com
Country: China
ProdList: 6945
Advantage: 52

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

Synthetics China Co.,Ltd

Tel: 0512-65218020 18248732722
Email: biz@pharmsyn.com
Country: China
ProdList: 99
Advantage: 60

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9546
Advantage: 55

Shanghai Synmedia Chemical Co., Ltd.

Tel: 021-38681880 13817889927
Fax: 0213390-8196
Email: sales@synmedia-chem.com
Country: China
ProdList: 249
Advantage: 58

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9979
Advantage: 55

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13350
Advantage: 58

Hefei TianRui Pharmaceutical Chemistry Co., Ltd.

Tel: 0551-68933033 13956024211
Fax: 0551-68935833
Email: trchem@163.com
Country: China
ProdList: 98
Advantage: 58

Beijing FYF Chemicals Co., Ltd

Tel: 010-57903446 15869909019
Fax: 010-57903446
Email: 168931144@qq.com
Country: China
ProdList: 2875
Advantage: 58

Hunan HuaTeng Pharmaceutical Co., Ltd.,

Tel: 400-8592883
Fax: 0731-82251112
Email: sales@huatengsci.com
Country: China
ProdList: 5872
Advantage: 58

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

Gansu HaoTian Chemical Technology Co., Ltd.

Tel: 0943-6900332 17789447501
Fax: 0931-8238232
Email: zhuanxiajiang@haotianpharm.com
Country: China
ProdList: 192
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Chengdu RunZeBenTu Chemical Co., Ltd

Tel: 028-88469284 18000562381
Email: rzbtsj@163.com
Country: China
ProdList: 9951
Advantage: 56

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

Nanjing XiLang Chemical Products Co., Ltd.

Tel: 18936048580
Email: chemxilang@163.com
Country: China
ProdList: 3909
Advantage: 58

Shanghai Xilong Biochemical Technology Co., Ltd.

Tel: 021-52907766-8042
Fax: 021-52906523
Country: China
ProdList: 9941
Advantage: 58

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Grader reagent

Tel: 18221735425
Email: sales@xinpingchem.com
Country: China
ProdList: 9942
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 10109
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29759
Advantage: 68

Shenzhen Simeiquan Biotechnology Co. Ltd

Tel: 18126413629 0755-23311925 2355327053
Fax: 0755-23311925
Email: abel@ycgmp.com
Country: China
ProdList: 5113
Advantage: 58

Shijiazhuang yaoBo Pharmaceutical Co., Ltd.

Tel: 15633056635
Email: 2880679888@qq.com
Country: China
ProdList: 2373
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886750 13927877953
Fax: 0751-2886750
Email: 3005811397@qq.com
Country: China
ProdList: 13305
Advantage: 58

TIANJIN MINXIANG BIOMEDICAL INC.

Tel: 13313219033; 13313219033
Fax: 86-22-88718329
Email: tjmx@mxpharm.com
Country: China
ProdList: 50
Advantage: 58

Shenzhen Sendi Biological Technology Co., Ltd.

Tel: 18124570582 TEL：0755-23574479 2355327139
Fax: 0755-23229476 QQ: 2355327139
Email: siliao02@yccreate.com
Country: China
ProdList: 6116
Advantage: 58

Guangzhou Kafen Biotech Co.,Ltd

Tel: 18029243487 2355327168
Fax: 020-31121510
Email: gy@yccreate.com
Country: China
ProdList: 4749
Advantage: 55

Wuhai Shuou Technology Co., Ltd.

Tel: 17792809151
Fax: 18872220797
Email: 2355916837@ycphar.com
Country: China
ProdList: 6133
Advantage: 55

Henan Anky Chemical Technology Co., Ltd.

Tel: 17836913271
Fax: 0374-8348899
Email: 3224305243@qq.com
Country: China
ProdList: 2952
Advantage: 58

Taian Jiaye Biotechnology Co.Ltd

Tel: 13127280945
Email: 285424065@qq.com
Country: China
ProdList: 9976
Advantage: 55

Shandong Ono Chemical Co., Ltd.

Tel: 0539-6362799 20）
Fax: 0539-6362799（To 20）
Country: China
ProdList: 10007
Advantage: 58

Shanghai BaiShun Biological Technology Co., Ltd

Tel: 021-37581181
Fax: 021-57456066
Email: sales@chem-mall.com
Country: China
ProdList: 10330
Advantage: 58

Less

View Lastest Price from 2H-1,3-Benzoxazine-2,4(3H)-dione manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: 2H-1,3-Benzoxazine-2,4(3H)-dione 2037-95-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-27

Shaanxi Dideu New Materials Co. Ltd

Product: 2H-1,3-Benzoxazine-2,4(3H)-dione 2037-95-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-15

Henan Aochuang Chemical Co.,Ltd.

Product: 2H-1,3-Benzoxazine-2,4(3H)-dione;Carsalam 2037-95-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-28

2037-95-8, 2H-1,3-Benzoxazine-2,4(3H)-dioneRelated Search:

3-[2-(Diethylamino)ethyl]-2H-1,3-benzoxazine-2,4(3H)-dione 6-Chloro-2H-3,1-benzoxazine-2,4(1H)-dione,6-Chloro-4H-3,1-benzoxazine-2(1H),4-dione,6-chloro-4h-3,1-benzoxazine-2,4(1h)-dione 7-METHOXY-1,3-BENZOXAZINE-2,4-DIONE Isatoic Anhydride N-methylisatoic anhydride 6-chloro-1-methyl-2H-3,1-benzoxazine-2,4(1H)-dione 2H-1,3-Benzoxazine-2,4(3H)-dione 6-BROMO-2H-BENZO[E][1,3]OXAZINE-2,4(3H)-DIONE 8-Hydroxy-2H-1,3-benzoxazine-2,4(3H)-dione 6-Hydroxy-2H-3,1-benzoxazine-2,4(1H)-dione 3-Methyl-2H-1,3-benzoxazine-2,4(3H)-dione 2H-1,4-BENZOXAZINE-2,3(4H)-DIONE 3-OXIME 6-METHYL-2H-1,4-BENZOXAZINE-2,3(4H)-DIONE 3-OXIME 6-CHLORO-2H-1,4-BENZOXAZINE-2,3(4H)-DIONE 3-OXIME 5-Nitro-2H-3,1-benzoxazine-2,4(1H)-dione 7-Methyl-2H-1,3-benzoxazine-2,4(3H)-dione 5-FLUORO-2H-3,1-BENZOXAZINE-2,4(1H)-DIONE 2H-1,4-benzoxazine-2,3(4H)-dione

beaprine

carsalam

oxophenhydroxazine

ruhmal

TIMTEC-BB SBB003929

1,3-BENZOXAZINE-2,4-DIONE

2H-1,3-Benzoxazine-2,4(3H)-dione 98%

CAS:2037-95-8

Carsalam≥ 99% (HPLC)

Two ketone

2 H-1,3-BENZOXAZINE-2,4(3 H)-DIONE

1,3-Benzoxazine-2,4-(3H)-dione

Carsalame

Carbonylsalicylamide

1,3-benzoxazine-2,4-quinone

2H-Benzo[e][1,3]oxazine-2,4(3H)-dione

CarsalaM (1,3-benzoxazine-2,4-(3H)-dione)

2,4-Dioxo-3,4-dihydro-2H-1,3-benzoxazine

3,4-dihydro-2H-1,3-benzoxazine-2,4-dione

2 H-1,3-BENZOXAZINE-2,4(3 H)-DIONE ISO 9001：2015 REACH

3-BENZOXAZINE-2

4(3 H)-DIONE

Carsalam(Carbonyl salicylamide)

Kasharin reference substance

Salcaprozate Impurity 9

Cacharon

8- (2-hydroxybenzamide) sodium octanoate impurity 22

Carsalam, 10 mM in DMSO

2<i>H</i>-1,3-Benzoxazine-2,4(3<i>H</i>)-dione

Casalen

Caxaran

Oxolinicdiketone

Kasaron

2037-95-8

2307-95-8

2037-65-8

Building Blocks

Benzoxazines

Heterocyclic Building Blocks

Benzoxazines

Building Blocks

Heterocyclic Building Blocks