2H-1,3-Benzoxazine-2,4(3H)-dione
- Product Name
- 2H-1,3-Benzoxazine-2,4(3H)-dione
- CAS No.
- 2037-95-8
- Chemical Name
- 2H-1,3-Benzoxazine-2,4(3H)-dione
- Synonyms
- ruhmal;carsalam;beaprine;Cacharon;Carsalame;Two ketone;4(3 H)-DIONE;CAS:2037-95-8;3-BENZOXAZINE-2;oxophenhydroxazine
- CBNumber
- CB7736467
- Molecular Formula
- C8H5NO3
- Formula Weight
- 163.13
- MOL File
- 2037-95-8.mol
2H-1,3-Benzoxazine-2,4(3H)-dione Property
- Melting point:
- 228-232 °C(lit.)
- Density
- 1.402±0.06 g/cm3(Predicted)
- vapor pressure
- 0.73-1.27Pa at 89.94-107.94℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO : ≥ 40 mg/mL (245.20 mM)
- form
- Solid
- pka
- 9.16±0.20(Predicted)
- color
- White to off-white
- Merck
- 13,1879
- InChI
- InChI=1S/C8H5NO3/c10-7-5-3-1-2-4-6(5)12-8(11)9-7/h1-4H,(H,9,10,11)
- InChIKey
- OAYRYNVEFFWSHK-UHFFFAOYSA-N
- SMILES
- O1C2=CC=CC=C2C(=O)NC1=O
- LogP
- 0.78-0.88 at 20℃
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C184748
- Product name
- Carsalam
- Packaging
- 10g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- C6933
- Product name
- Carsalam
- Packaging
- 200mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- OR941085
- Product name
- 2H-Benzo[e][1,3]oxazine-2,4(3H)-dione
- Purity
- 95%
- Packaging
- 25g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- FB45734
- Product name
- 2H-1,3-Benzoxazine-2,4(3H)-dione
- Packaging
- 25g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- J20503
- Product name
- Carsalam
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
2H-1,3-Benzoxazine-2,4(3H)-dione Chemical Properties,Usage,Production
Chemical Properties
Off-white to light brown crystalline powder
Uses
analgesic
Definition
ChEBI: Carsalam is a benzoxazine.
General Description
Kinetic studies of the alkaline hydrolysis of 2H-1,3-benzoxazine-2,4(3H)-dione (carsalam) were conducted and reaction was found to be of fractional order with respect to [OH-].
Synthesis
2H-1,3-Benzoxazine-2,4(3H)-dione was prepared according to the procedure of Hoback, Crum and Carroll. To a solution of 411 g. (3. 0 moles) salicylamide in 483 ml. (6.0 moles) of anhydrous pyridine at 0℃ was added slowly with stirring 572 ml. (6.0 moles) of ethyl chlorocarbonate. The resulting orange solution was refluxed for 5 hr. and poured into 2L of ice water. The filtered product was washed twice with 0.5L of water and recrystallized three times from acetone-ethanol (50: 50), giving white needles 2H-1,3-Benzoxazine-2,4(3H)-dione (83% yield), m.p. 227.5-228.5° (lit. 12), m.p. 227-228°, which gave no coloration with ethanolic ferric chloride[1].
References
[1] J. D. Crum, J. A. Franks Jr. “The chemistry of heterocycles. III. 2H-1,3-benzoxazine-2,4(3H)-dione and Some 3-substituted derivatives.??.” Journal of Heterocyclic Chemistry 2 1 (1965): 37–40.
2H-1,3-Benzoxazine-2,4(3H)-dione Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2H-1,3-Benzoxazine-2,4(3H)-dione manufacturers
- Product
- 2H-1,3-Benzoxazine-2,4(3H)-dione;Carsalam 2037-95-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-28
- Product
- 1,3-benzoxazine-2,4-dione 2037-95-8
- Price
- US $0.00/KG
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 1 ton
- Release date
- 2019-10-24
- Product
- 2H-1,3-Benzoxazine-2,4(3H)-dione 2037-95-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 10g
- Purity
- 99.0%+
- Supply Ability
- 100 tons
- Release date
- 2019-12-25