4-AMINOMETHYLINDOLE
- Product Name
- 4-AMINOMETHYLINDOLE
- CAS No.
- 3468-18-6
- Chemical Name
- 4-AMINOMETHYLINDOLE
- Synonyms
- NSC 131886;4-AMINOMETHYLINDOLE;CHEMBRDG-BB 4003293;INDOLE-4-METHYLAMINE;1H-INDOLE-4-METHANAMINE;1H-Indol-4-ylmethanamine;(1H-Indol-4-ymetyl)amine;4-(Aminomethyl)indole 95%;(1H-INDOL-4-YLMETHYL)AMINE;C-(1H-INDOL-4-YL)-METHYLAMINE
- CBNumber
- CB7744486
- Molecular Formula
- C9H10N2
- Formula Weight
- 146.19
- MOL File
- 3468-18-6.mol
4-AMINOMETHYLINDOLE Property
- Melting point:
- 132℃
- Boiling point:
- 335.6±17.0 °C(Predicted)
- Density
- 1.199
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Soluble in ethanol, dimethyl sulfoxide and dimethyl formamide.
- pka
- 17.21±0.30(Predicted)
- form
- A crystalline solid
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-41-37/38-22
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 10007085
- Product name
- 4-Aminomethylindole
- Purity
- ≥99%
- Packaging
- 500mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 10007085
- Product name
- 4-Aminomethylindole
- Purity
- ≥99%
- Packaging
- 1g
- Price
- $110
- Updated
- 2024/03/01
- Product number
- 10007085
- Product name
- 4-Aminomethylindole
- Purity
- ≥99%
- Packaging
- 5g
- Price
- $468
- Updated
- 2024/03/01
- Product number
- A633448
- Product name
- 4-Aminomethylindole
- Packaging
- 100mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- A633448
- Product name
- 4-Aminomethylindole
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
4-AMINOMETHYLINDOLE Chemical Properties,Usage,Production
Description
4-
Uses
4-Aminomethylindole is a useful research intermediate used in the preparation of dopamine receptor antagonist.
Uses
Reactant for preparation of dopamine receptor antagonists 1 Reactant for preparation of high-affinity ligands to α2δ subunit of voltage-gated calcium channels 2
Uses
4-(Aminomethyl)indole is used as a reactant for preparation of dopamine receptor antagonists and for preparation of high-affinity ligands to α2δ subunit of voltage-gated calcium channels. It is used as a synthetic intermediate.
Definition
ChEBI: 4-Aminomethylindole is a member of indoles.
Synthesis
16136-52-0
3468-18-6
The general procedure for the synthesis of 4-(aminomethyl)indole from 4-cyanoindole was as follows:Preparation of C-(1H-indol-4-yl)-methylamine. At room temperature, 4-cyanoindole (7.5 g, 53 mmol) was dissolved in THF (100 ml) and then slowly added to 1.0 M lithium aluminum hydride solution in THF (100 ml). The reaction mixture was heated to reflux for 30 min and subsequently cooled to room temperature. After completion of the reaction, the reaction mixture was quenched with 1N NaOH solution and filtered. The filtrate was acidified with 1N HCl and stirred at room temperature for 10 minutes. Subsequently, the pH was adjusted to about 10, saturated NaHCO3 solution was added and extracted with n-butanol. The organic layer was separated and concentrated to dryness. The residue was ground with methanol, filtered to remove insoluble matter and the filtrate was concentrated under reduced pressure to give the target product. The final product was dried under high vacuum at 50 °C to give a white solid (7.27 g, 94% yield).
References
[1] Journal of Medicinal Chemistry, 2010, vol. 53, # 6, p. 2646 - 2650
[2] Patent: US2012/238569, 2012, A1. Location in patent: Page/Page column 29
[3] European Journal of Medicinal Chemistry, 2017, vol. 134, p. 13 - 23
[4] Catalysis Science and Technology, 2014, vol. 4, # 3, p. 629 - 632
4-AMINOMETHYLINDOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-AMINOMETHYLINDOLE manufacturers
- Product
- 1H-indol-4-ylmethanamine 3468-18-6
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-09