2-Picoline-N-oxide

Product Name: 2-Picoline-N-oxide
CAS No.: 931-19-1
Chemical Name: 2-Picoline-N-oxide
Synonyms: 2-picoline-oxide;-Picoline N-oxide;a-Picoline N-oxide;a-Picoline 1-oxide;2-PICOLINE-N-OXIDE;2-Picoline, 1-oxide;Alfa picoline oxide;2-Picoline-N-oxide,98%;alpha-Picoline 1-oxide;ALPHA-PICOLINE N-OXIDE
CBNumber: CB7748015
Molecular Formula: C6H7NO
Formula Weight: 109.13
MOL File: 931-19-1.mol

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2-Picoline-N-oxide Property

Melting point:: 41-45 °C(lit.)
Boiling point:: 259-261 °C
Density: 1.1143 (rough estimate)
refractive index: 1.5444 (estimate)
Flash point:: >230 °F
storage temp.: RT, stored under nitrogen
pka: pK1:1.029(+1) (25°C)
form: powder to lump to clear liquid
color: White or Colorless to Light yellow
Water Solubility: soluble
Sensitive: Hygroscopic
BRN: 106916
InChI: InChI=1S/C6H7NO/c1-6-4-2-3-5-7(6)8/h2-5H,1H3
InChIKey: CFZKDDTWZYUZKS-UHFFFAOYSA-N
SMILES: C1(C)[N+]([O-])=CC=CC=1
CAS DataBase Reference: 931-19-1(CAS DataBase Reference)
NIST Chemistry Reference: Pyridine, 2-methyl-, 1-oxide(931-19-1)
EPA Substance Registry System: 2-Methylpyridine-1-oxide (931-19-1)

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Safety

Hazard Codes: Xi,Xn,F
Risk Statements: 36/37/38-20/21/22-10
Safety Statements: 26-36-24/25-16
WGK Germany: 3
F: 3
TSCA: TSCA listed
HS Code: 29333990
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P42207
Product name: 2-Methylpyridine N-oxide
Purity: ≥96%
Packaging: 100g
Price: $140
Updated: 2023/06/20

TCI Chemical

Product number: P0418
Product name: 2-Methylpyridine N-Oxide
Purity: >99.0%(GC)
Packaging: 25g
Price: $34
Updated: 2025/07/31

TCI Chemical

Product number: P0418
Product name: 2-Methylpyridine N-Oxide
Purity: >99.0%(GC)
Packaging: 500g
Price: $247
Updated: 2025/07/31

TRC

Product number: M340915
Product name: 2-Methylpyridine1-oxide
Packaging: 25g
Price: $45
Updated: 2021/12/16

TRC

Product number: M340915
Product name: 2-Methylpyridine1-oxide
Packaging: 50g
Price: $60
Updated: 2021/12/16

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2-Picoline-N-oxide Chemical Properties,Usage,Production

Chemical Properties

light yellow to brown crystalline low melting mass

Uses

2-Picoline N-oxide is used in proteomics research. Also used as pharmaceutical intermediates.

Application

2-Methylpyridine 1-oxide is a useful building block for organic synthesis.

Definition

ChEBI: Picoline N-oxide is a member of methylpyridines and a member of pyridine N-oxides.

Synthesis

K2CO3 (20 mmol) and urea peroxide (10 mmol) were dissolved in dry 1,4-dioxane (100 mL), which was then stirred and reacted at room temperature for 1 hour. Trifluoroacetic anhydride (10 mmol) was added dropwise to the mixture below 12 ??C to bring the mixture back to room temperature. To the reaction mixture was added the corresponding 2-methylpyridine (1 mmol) and the mixture was stirred at 50 ??C overnight. The 1,4-dioxane was removed by distillation and replaced with dichloromethane, the mixture was washed with water (50 mL) and the resulting organic layer was dried over anhydrous MgSO4, filtered to remove the desiccant and the resulting filtrate was concentrated under vacuum to remove the solvent to give the 2-methylpyridine oxide.

Purification Methods

Purify the N-oxide by fractional distillation, and it can be recrystallised from *C6H6/hexane but is hygroscopic. [Bullitt & Maynard J Am Chem Soc 76 1370 1954, Ross et al. J Am Chem Soc 78 3625 1956, IR: Wiley & SlaymAker J Am Chem Soc 79 2233 1957.] The picrate has m 125-126.5o (from EtOH) [Boekelheide & Linn J Am Chem Soc 76 1286 1954]. The phthalate has m 115-116o (from EtOH) [den Hertog et al. Recl Trav Chim Pays-Bas 70 591 1951.]. [Beilstein 20 III/IV 2689, 20/5 V 479.]

2-Picoline-N-oxide Preparation Products And Raw materials

Raw materials

Preparation Products

4-(DIMETHYLAMINO)PYRIDINE-2-CARBOXYLIC ACID

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2-Picoline-N-oxide Suppliers

Americas 1 Belgium 3 China 193 Europe 4 Germany 6 India 37 Japan 4 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 2 United Kingdom 11 United States 38 Global 303

Suzhou Highfine Biotech Co., Ltd

Tel: 0512-68417696 13962195629
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Anhui Dexinjia Biopharm Co., Ltd

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Email: 3416953599@qq.com
Country: China
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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
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Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
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INTATRADE GmbH

Tel: +49 3493/605464
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Email: sales@intatrade.de
Country: Germany
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Alfa Aesar

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TCI (Shanghai) Development Co., Ltd.

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Energy Chemical

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Shijiazhuang Sdyano Fine Chemical Co., Ltd.

Tel: 0311-89250318 031166536426
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Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
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View Lastest Price from 2-Picoline-N-oxide manufacturers

Anhui Dexinjia Biopharm Co., Ltd

Product: 2-Picoline-N-oxide 931-19-1
Price: US $100.00-2500.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 5MT per month
Release date: 2025-05-19

Career Henan Chemical Co

Product: 2-Picoline-N-oxide 931-19-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2019-05-24

931-19-1, 2-Picoline-N-oxideRelated Search:

2,6-Lutidine 2,4,6-Collidine Pyridine-N-oxide Azamethiphos Magnesium oxide Iron oxide Iron oxide black Zinc oxide 2,2,6,6-Tetramethylpiperidinooxy NITRIC OXIDE 2-Chloro-5-chloromethylpyridine 2-Picoline ETHYLENE OXIDE Chromium picolinate 4-Methylpyridine Rutile (Diethoxymethyl)diphenylphosphine oxide 7-CHLORO-1,3-DIHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPINE-2-ONE-4-OXIDE

2-PICOLINE-N-OXIDE 95%(MIN)

2-Methylpyridine-N-oxide hemihydrate(2-Picoline-N-oxide hemihydrate)

Alpha-picoline N-oxide, 2-Picoline N-oxide

2-Methyl-1-oxidopyridin-1-ium

a-Picoline 1-oxide

a-Picoline N-oxide

1-Oxylato-2-methylpyridinium

2-Picoline-N-oxide,98%

Pyridinium, 1-hydroxy-2-methyl-, chloride

2-Methyl pyridine oxide

2-Methyl-1$l^{5}-pyridin-1-one

2-Methylpyridine N-oxide >=96%

2-Methylpyridine <i>N</i>-Oxide

2-methyl-pyridin1-oxide

2-Picoline, 1-oxide

2-picoline-oxide

alpha-Picoline 1-oxide

-Picoline N-oxide

Pyridine,2-methyl-,1-oxide

N-OXIDE OF 2-METHYL PYRIDINE

ALPHA-PICOLINE N-OXIDE

2-PICOLINE-N-OXIDE

2-METHYLPYRIDINE N-OXIDE

2-METHYLPYRIDINE 1-OXIDE

2-PICOLINE N-OXIDE, 96+%

Alfa picoline oxide

2-MethylpyridineN-Oxide&gt

Pyridinium, 1-hydroxy-2-methyL

2-Picoline-N-oxide ISO 9001：2015 REACH

Alfa picoline -N-oxide

2-PicolineN-oxide, 95%

2-Methylpyridine N-Oxide,98% (contains <5%H2O)

931-19-1

1931-19-1

Building Blocks

Heterocyclic Building Blocks

Pyridines

C6

Pyridines

Pyridine

bc0001