Cyclopentyl chloroformate
- Product Name
- Cyclopentyl chloroformate
- CAS No.
- 50715-28-1
- Chemical Name
- Cyclopentyl chloroformate
- Synonyms
- Cyclopentyl carbonochloridate;yclopentyl chloroformate;CYCLOPENTYL CHLOROFORMATE;Cyclopentyl carbonochloridoate;CARBONOCHLORIDIC ACID, CYCLOPENTYL ESTER;Cyclopentyl carbonochloridoate, [(Chlorocarbonyl)oxy]cyclopentane, [(Chloroformyl)oxy]cyclopentane
- CBNumber
- CB7751594
- Molecular Formula
- C6H9ClO2
- Formula Weight
- 148.59
- MOL File
- 50715-28-1.mol
Cyclopentyl chloroformate Property
- Boiling point:
- 69.0-70.5 °C(Press: 25 Torr)
- Density
- 1.19±0.1 g/cm3(Predicted)
- form
- liquid
- color
- Brown
- InChI
- InChI=1S/C6H9ClO2/c7-6(8)9-5-3-1-2-4-5/h5H,1-4H2
- InChIKey
- ZFQCRLNKHHXELH-UHFFFAOYSA-N
- SMILES
- C(Cl)(OC1CCCC1)=O
- CAS DataBase Reference
- 50715-28-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,T
- Risk Statements
- 10-22-23-41-43-48/22
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN3277
- Hazard Note
- Irritant
- HazardClass
- 6.1, 8
- HS Code
- 2916200090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H317May cause an allergic skin reaction
H318Causes serious eye damage
H331Toxic if inhaled
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- C989930
- Product name
- CyclopentylChloroformate
- Packaging
- 25g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- 2223-5-X0
- Product name
- Cyclopentyl chloroformate
- Purity
- 95.0%
- Packaging
- 25g
- Price
- $350
- Updated
- 2021/12/16
- Product number
- FC01775
- Product name
- Cyclopentyl chloroformate
- Packaging
- 50g
- Price
- $350
- Updated
- 2021/12/16
- Product number
- FC01775
- Product name
- Cyclopentyl chloroformate
- Packaging
- 100g
- Price
- $500
- Updated
- 2021/12/16
- Product number
- HCH0025728
- Product name
- CYCLOPENTYL CHLOROFORMATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $708.48
- Updated
- 2021/12/16
Cyclopentyl chloroformate Chemical Properties,Usage,Production
Uses
Cyclopentyl Chloroformate is a chemical reagent used in the synthesis of novel peptidomimetic Hep C protease inhibitors.
Synthesis
32315-10-9
96-41-3
50715-28-1
A mixed solution of cyclopentanol (10.9 mL, 120 mmol) and pyridine (10.7 mL, 132 mmol) was added slowly and dropwise to a solution of triphosgene (11.87 g, 40.0 mmol) in anhydrous ether (100 mL) at -70 °C. The reaction mixture was stirred continuously for 1 h at this temperature and then removed from the low temperature bath. Stirring was continued at room temperature for 1.5 h. Subsequently, 1.0 N HCl aqueous solution (110 mL) was added for acidification. The organic phase was separated, washed with brine (60 mL) and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure to afford cyclopentyl chloroformate (14.395 g, boiling point 80 °C/75 mmHg, 80.7% yield). The resulting cyclopentyl chloroformate could be used directly in the subsequent reaction without further purification.
References
[1] Patent: CN106045802, 2016, A. Location in patent: Paragraph 0044-0045
[2] Patent: WO2008/95058, 2008, A1. Location in patent: Page/Page column 31
[3] European Journal of Medicinal Chemistry, 1993, vol. 28, # 1, p. 37 - 45
[4] Patent: WO2008/38175, 2008, A2. Location in patent: Page/Page column 38
[5] Patent: CN107417748, 2017, A. Location in patent: Paragraph 0106
Cyclopentyl chloroformate Preparation Products And Raw materials
Raw materials
Preparation Products
Cyclopentyl chloroformate Suppliers
- Tel
- --
- Fax
- --
- chemcontrol@nextra.sk
- Country
- Slovakia
- ProdList
- 6700
- Advantage
- 60
View Lastest Price from Cyclopentyl chloroformate manufacturers
- Product
- Cyclopentyl chloroformate 50715-28-1
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-15