4-Cbz-Aminopiperidine
- Product Name
- 4-Cbz-Aminopiperidine
- CAS No.
- 182223-54-7
- Chemical Name
- 4-Cbz-Aminopiperidine
- Synonyms
- 4-CBZ-AMINOPIPERIDINE;4-(Z-amino)-piperidine;N-CBZ-piperidin-4-aMine;Benzylpiperidin-4-ylcarbamate;Benzyl 4-Piperidinylcarbamate;4-Benzyloxycarbonylamino-piperdine;benzyl N-(piperidin-4-yl)carbaMate;4-BENZYLOXYCARBONYLAMINO-PIPERIDINE;Phenylmethyl N-4-piperidinylcarbamate;benzyl piperidin-4-ylcarbamate hydrochloride
- CBNumber
- CB7756599
- Molecular Formula
- C13H18N2O2
- Formula Weight
- 234.29
- MOL File
- 182223-54-7.mol
4-Cbz-Aminopiperidine Property
- Boiling point:
- 396.3±41.0 °C(Predicted)
- Density
- 1.13±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Dichloromethane
- form
- Solid
- pka
- 12.18±0.20(Predicted)
- color
- White
- InChI
- InChI=1S/C13H18N2O2/c16-13(15-12-6-8-14-9-7-12)17-10-11-4-2-1-3-5-11/h1-5,12,14H,6-10H2,(H,15,16)
- InChIKey
- WWGUAFRTAYMNHU-UHFFFAOYSA-N
- SMILES
- C(OCC1=CC=CC=C1)(=O)NC1CCNCC1
Safety
- Safety Statements
- 24/25
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B285871
- Product name
- 4-Benzyloxycarbonylaminopiperidine
- Packaging
- 1g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- B285871
- Product name
- 4-Benzyloxycarbonylaminopiperidine
- Packaging
- 2.5g
- Price
- $330
- Updated
- 2021/12/16
- Product number
- 076533
- Product name
- 4-Cbz-Aminopiperidine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $63
- Updated
- 2021/12/16
- Product number
- FC148389
- Product name
- 4-Cbz-aminopiperidine
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- OR301035
- Product name
- 4-Benzyloxycarbonylaminopiperidine
- Packaging
- 1g
- Price
- $138
- Updated
- 2021/12/16
4-Cbz-Aminopiperidine Chemical Properties,Usage,Production
Uses
4-Benzyloxycarbonylaminopiperidine is an intermediate in synthesizing 7-Ethyl-10-(4-amino-1-piperidino)carbonyloxycamptothecin (E899150), a major metabolite of Irinotecan.
Definition
ChEBI: Benzyl 4-piperidinylcarbamate is a member of piperidines.
Synthesis
220394-97-8
182223-54-7
The general procedure for the synthesis of 4-(N-benzyloxycarbonyl)-aminopiperidine from 1-Boc-4-(Cbz-amino)piperidine was as follows: tert-butyl 4-{[(benzyloxy)carbonyl]amino}piperidine-1-carboxylate (13.1 g, 39.2 mmol) obtained in Example 1a was mixed with a 5N aqueous hydrochloric acid (40 ml, 200 mmol) and a methanolic (40 ml) The mixture was stirred at room temperature for 23 hours. After completion of the reaction, 5N aqueous sodium hydroxide solution (40 ml) was slowly added to the reaction mixture under ice bath cooling conditions. Subsequently, water and solvent were removed from the reaction mixture by distillation while azeotropic distillation using ethanol was carried out to remove water completely. Ethanol was added to the distilled residue, filtered to remove insoluble matter, and the filtrate was concentrated to give the final 4-(N-benzyloxycarbonyl)-aminopiperidine (9.10 g, 99.1% yield). The product was characterized by 1H-NMR (400 MHz, CDCl3) with the following chemical shifts δppm: 1.31-1.42 (2H, m), 1.92-2.04 (2H, br), 2.70 (2H, d, J = 12Hz), 3.10 (2H, d, J = 12Hz), 3.56-3.68 (1H, br), 4.72- 4.81 (1H, br), 5.09 (2H, s), 7.26-7.40 (5H, m).
References
[1] Patent: US2013/65925, 2013, A1. Location in patent: Paragraph 0197; 0198
[2] Patent: EP2757103, 2014, A1. Location in patent: Paragraph 0149
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 3, p. 1021 - 1046
[4] Patent: WO2011/60321, 2011, A1. Location in patent: Page/Page column 115
[5] Patent: WO2006/99884, 2006, A1. Location in patent: Page/Page column 18
4-Cbz-Aminopiperidine Preparation Products And Raw materials
Raw materials
Preparation Products
4-Cbz-Aminopiperidine Suppliers
- Tel
- --
- Fax
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- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
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- sales@apolloscientific.co.uk
- Country
- United Kingdom
- ProdList
- 6084
- Advantage
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- Tel
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- Country
- United Kingdom
- ProdList
- 6565
- Advantage
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View Lastest Price from 4-Cbz-Aminopiperidine manufacturers
- Product
- N-CBZ-piperidin-4-aMine 182223-54-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 4-Cbz-Aminopiperidine 182223-54-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-24