ChemicalBook > CAS DataBase List > 2'-FLUORO-6'-HYDROXYACETOPHENONE

2'-FLUORO-6'-HYDROXYACETOPHENONE

Product Name
2'-FLUORO-6'-HYDROXYACETOPHENONE
CAS No.
93339-98-1
Chemical Name
2'-FLUORO-6'-HYDROXYACETOPHENONE
Synonyms
2-FLUORO-6-HYDROXYACETOPHENONE;2'-Fluoro-6'-hydroxyacetophenone;1-(2-FLUORO-6-HYDROXYPHENYL)ETHANONE;1-(2-Fluoro-6-hydroxyphenyl)ethan-1-one;Ethanone, 1-(2-fluoro-6-hydroxyphenyl)-;1-(2-Fluoro-6-hydroxyphenyl)ethan-1-one, 2-Acetyl-3-fluorophenol
CBNumber
CB7757152
Molecular Formula
C8H7FO2
Formula Weight
154.14
MOL File
93339-98-1.mol
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2'-FLUORO-6'-HYDROXYACETOPHENONE Property

Boiling point:
224.0±20.0 °C(Predicted)
Density 
1.25g/ml
refractive index 
1.534
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
liquid
pka
9.17±0.10(Predicted)
color 
Clear, faint lime
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Safety

Hazard Codes 
Xi
Hazard Note 
Irritant
HS Code 
2914500090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
F598130
Product name
1-(2-Fluoro-6-hydroxyphenyl)ethanone
Packaging
10mg
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
PC9896
Product name
2'-Fluoro-6'-hydroxyacetophenone
Packaging
1g
Price
$85
Updated
2021/12/16
SynQuest Laboratories
Product number
2620-3-X7
Product name
2'-Fluoro-6'-hydroxyacetophenone
Packaging
1g
Price
$93
Updated
2021/12/16
Apolloscientific
Product number
PC9896
Product name
2'-Fluoro-6'-hydroxyacetophenone
Packaging
5g
Price
$254
Updated
2021/12/16
SynQuest Laboratories
Product number
2620-3-X7
Product name
2'-Fluoro-6'-hydroxyacetophenone
Packaging
5G
Price
$280
Updated
2021/12/16
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2'-FLUORO-6'-HYDROXYACETOPHENONE Chemical Properties,Usage,Production

Preparation

Preparation by reaction of boron tribromide on 2-fluoro-6- methoxyacetophenone (I) in methylene chloride at ?65° to ?80° (56%). The precursor (I) was obtained by reaction of methyl magnesium iodide on 2-fluoro-6-methoxybenzonitrile in refluxing toluene (quantitative yield).

Synthesis

120484-50-6

93339-98-1

General procedure for the synthesis of 2-fluoro-6-hydroxyacetophenone from 2-fluoro-6-methoxyacetophenone: aluminum chloride (14.3 g, 0.107 mol) was added to an ice-cold solution of intermediate 3 (9.0 g, 53.5 mmol) in dichloromethane (70 mL), followed by slow warming of the reaction mixture to room temperature. After the reaction was carried out for 12 h, the reaction was quenched with aqueous 2N hydrochloric acid and extracted with ethyl acetate. The organic layer was washed sequentially with water, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 2-fluoro-6-hydroxyacetophenone as a brown liquid (5.48 g, 66% yield). The product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, CDCl3, 400 MHz): δ 12.72 (s, 1H, OH), 7.40 (m, 1H, Ar-H), 6.78 (d, J = 8.5 Hz, 1H, Ar-H), 6.62 (dd, J = 11.3, 8.3 Hz, 1H, Ar-H), 2.69 (d, J = 7.2 Hz, 3H, CH3).

References

[1] Patent: WO2012/151525, 2012, A1. Location in patent: Page/Page column 101
[2] Patent: US2012/289496, 2012, A1. Location in patent: Page/Page column 100
[3] Patent: US5399584, 1995, A
[4] Patent: US2007/14733, 2007, A1. Location in patent: Sheet 14
[5] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 619 - 622

2'-FLUORO-6'-HYDROXYACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-FLUORO-6'-HYDROXYACETOPHENONE Suppliers

Belgium 1 China 83 France 1 Germany 4 India 4 The Netherlands 2 United Kingdom 11 United States 17 Global 123
Ark Pharm, Inc.
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View Lastest Price from 2'-FLUORO-6'-HYDROXYACETOPHENONE manufacturers

Career Henan Chemical Co
Product
2'-FLUORO-6'-HYDROXYACETOPHENONE 93339-98-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-11

93339-98-1, 2'-FLUORO-6'-HYDROXYACETOPHENONERelated Search:

5-Fluoro-4-chromanone 2'-FLUORO-6'-HYDROXYACETOPHENONE R547 2'-FLUORO-6'-METHOXYACETOPHENONE 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE 2'-FLUORO-4'-HYDROXYACETOPHENONE,2-FLUORO-4-HYDROXYACETOPHENONE 3-FLUORO-4-HYDROXYACETOPHENONE,3'-FLUORO-4'-HYDROXYACETOPHENONE,3'-Fluoro-4'-hydroxyacetophenone, 98+% 3''-Fluoro-2''-Hydroxyacetophenone 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone 4'-Fluoro-2'-hydroxyacetophenone 2-Bromo-1-(2-fluoro-6-hydroxyphenyl)ethanone 2-(4-CHLOROPHENYL)-5'-FLUORO-2'-HYDROXYACETOPHENONE 2'-FLUORO-5'-HYDROXYACETOPHENONE 2-BROMO-5'-FLUORO-2'-HYDROXYACETOPHENONE 1-[2-(cyclopentyloxy)-6-fluorophenyl]ethan-1-one 1-[2-fluoro-6-(oxolan-2-ylmethoxy)phenyl]ethan-1-one 1-[2-fluoro-6-(3-methylbutoxy)phenyl]ethan-1-one 5,6,7,8-TETRAFLUORO-2-METHYL-4-OXO-4H-CHROMENE-3-CARBOXYLIC ACID ETHYL ESTER

  • 1-(2-Fluoro-6-hydroxyphenyl)ethan-1-one
  • 1-(2-FLUORO-6-HYDROXYPHENYL)ETHANONE
  • 2-FLUORO-6-HYDROXYACETOPHENONE
  • 1-(2-Fluoro-6-hydroxyphenyl)ethan-1-one, 2-Acetyl-3-fluorophenol
  • Ethanone, 1-(2-fluoro-6-hydroxyphenyl)-
  • 2'-Fluoro-6'-hydroxyacetophenone
  • 93339-98-1
  • 9339-98-1
  • Aromatic Acetophenones & Derivatives (substituted)