Description References
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1,3-Butanediol

Description References
Product Name
1,3-Butanediol
CAS No.
107-88-0
Chemical Name
1,3-Butanediol
Synonyms
BD;Butane-1,3-diol;1,3-BUTYLENE GLYCOL;1,3-Butandiol;(3S)-butane-1,3-diol;3-Butanediol;BUTAN-1,3-DIOL;(±)-butane-1,3-diol;1-Methyl-1,3-propanediol;butane-1,
CBNumber
CB7758265
Molecular Formula
C4H10O2
Formula Weight
90.12
MOL File
107-88-0.mol
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1,3-Butanediol Property

Melting point:
-54 °C
Boiling point:
203-204 °C(lit.)
Density 
1.005 g/mL at 25 °C(lit.)
vapor density 
3.1 (20 °C, vs air)
vapor pressure 
0.06 mm Hg ( 20 °C)
refractive index 
n20/D 1.44(lit.)
Flash point:
250 °F
storage temp. 
Store below +30°C.
solubility 
>500g/lMiscible
form 
Liquid
pka
14.83±0.20(Predicted)
Specific Gravity
1.004 – 1.007
color 
Clear colorless to yellow, may discolor to brown on storage
PH
6.1 (500g/l, H2O, 20℃)
Odor
odorless
PH Range
6 - 7 at 20 °C
explosive limit
1.9-12.6%(V)
Water Solubility 
SOLUBLE
Sensitive 
Hygroscopic
Merck 
14,1567
BRN 
1731276
Stability:
Stable. Flammable. Hygroscopic - protect from air and moisture. Incompatible with strong oxidizing agents.
LogP
-0.9 at 25℃
CAS DataBase Reference
107-88-0(CAS DataBase Reference)
NIST Chemistry Reference
1,3-Butanediol(107-88-0)
EPA Substance Registry System
1,3-Butylene glycol (107-88-0)
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Safety

Safety Statements 
24/25
WGK Germany 
1
RTECS 
EK0440000
F 
3
Autoignition Temperature
741 °F
TSCA 
Yes
HS Code 
29053920
Hazardous Substances Data
107-88-0(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 18610 mg/kg LD50 dermal Rabbit > 20000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B84785
Product name
(±)-1,3-Butanediol
Purity
ReagentPlus?,99.5%
Packaging
18L
Price
$1230
Updated
2024/03/01
Sigma-Aldrich
Product number
8.01964
Product name
1,3-Butanediol
Purity
for synthesis
Packaging
1L
Price
$51.4
Updated
2024/03/01
Sigma-Aldrich
Product number
8.01964
Product name
1,3-Butanediol
Purity
for synthesis
Packaging
25KG
Price
$491
Updated
2024/03/01
Sigma-Aldrich
Product number
8.01964
Product name
1,3-Butanediol
Purity
for synthesis
Packaging
200KG
Price
$3560
Updated
2024/03/01
Sigma-Aldrich
Product number
09068
Product name
(±)-1,3-Butanediol
Purity
analytical standard
Packaging
1ml
Price
$72
Updated
2024/03/01
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1,3-Butanediol Chemical Properties,Usage,Production

Description

1,3-Butanediol is an organic chemical which belongs to the family of secondary alcohols. At present, 1,3-butanediol is used mainly in surfactants, inks, solvents for natural and synthetic flavoring agents and serves as a co-monomer in manufacturing certain polyurethane and polyester resins. It can also serve as a humectant to prevent loss of moisture in cosmetics, particularly in hair sprays and setting lotions. Besides, 1,3-Butanediol is pharmaceutically involved in the production of colchicine derivatives as a anticancer agent and in the synthesis of dual peroxisome proliferator-activated gamma and delta agonists acting as a hypoglycaemic agent, which is effective for the treatment of diabetes.

References

https://en.wikipedia.org/wiki/1,3-Butanediol
https://www.trc-canada.com/product-detail/?B690010
http://www.hmdb.ca/metabolites/HMDB31320
https://www.alfa.com/zh-cn/catalog/A11684/

Chemical Properties

1,3-Butanediol is a colorless oily liquid. Sp.Gr. 1.00. B.P. 207℃. Miscible with water, soluble in alcohol and many perfume and flavor materials, but poorly soluble in hydrocarbons (terpenes, etc.). 1,3-Butylene glycol has a sweet flavor with bitter aftertaste and is odorless when pure.

Chemical Properties

colourless liquid

Chemical Properties

Butylene glycol occurs as a clear, colorless, viscous liquid with a sweet flavor and bitter aftertaste.

Uses

(^+)-1,3-Butanediol acts as a co-monomer in the production of polyurethane and polyester resins. It is used as a humectant (to prevent loss of moisture) in cosmetics, especially in hair sprays and setting lotions. It is used in surfactants, inks, solvents for natural and synthetic flavorings. It is involved in the synthesis of dual peroxisome proliferator-activated gamma and delta agonists acting as euglycemic agents, which is used in the treatment of diabetes.

Uses

Its most extensive use is as an intermediate in the manufacture of polyester plasticisers and other chemical products. It finds some use as a solvent and humectant, a useful chemical intermediate. It has extensive application in the manufacture of structural materials for boats, custom mouldings, and sheets and boards for construction applications. 1,3-Butanediol imparts resistance to weathering plus flexibility and impact resistance. It is also used in the manufacture of saturated polyesters for polyurethane coatings, where the glycol imparts greater flexibility to the polyester molecule. 1,3-Butanediol is currently used in many personal care products.

Uses

1,3-Butanediol is used in the synthesis of colchicine derivatives as anticancer agents. Also used in the synthesis of dual peroxisome proliferator-activated gamma and delta agonists acting as euglycem ic agents in the treatment of diabetes.

Preparation

From formaldehyde and propylene via pressure and a catalyst.

Production Methods

Butylene glycol is prepared by catalytic hydrogenation of aldol using Raney nickel.

Definition

ChEBI: A butanediol compound having two hydroxy groups in the 1- and 3-positions.

Aroma threshold values

Detection: 70 to 100 ppm

General Description

(±)-1,3-Butanediol (BD) is a 1,3-diol. Its vapor pressure upto 270kPa, liquid-phase densities over a temperature range, two-phase (liquid + vapor) heat capacities, critical temperature and critical density have been determined. The obtained data was employed to derive various thermophysical properties.

Flammability and Explosibility

Not classified

Pharmaceutical Applications

Butylene glycol is used as a solvent and cosolvent for injectables. It is used in topical ointments, creams, and lotions, and it is also used as a vehicle in transdermal patches. Butylene glycol is a good solvent for many pharmaceuticals, especially estrogenic substances.
In an oil-in-water emulsion, butylene glycol exerts its best antimicrobial effects at ～8% concentration. Higher concentrations above 16.7% are required to inhibit fungal growth.

Contact allergens

This dihydric alcohol is used for its humectant and preservative potentiator properties in cosmetics, topical medicaments and polyurethane, polyester, cellophane, and cigarettes. It has similar properties, but is less irritant than propylene glycol. Contact allergies seem to be rare.

Side effects

1,3-Butanediol is commonly used as a solvent in food flavourings and is mildly toxic by oral and subcutaneous routes, with possible side effects including severe respiratory problems, coma, amnesia, belligerence, confusion, agitation, vomiting, seizures and very slow heartbeat. People who use butylene glycol on a regular basis and then stop using it may also experience withdrawal symptoms such as sleep problems (insomnia), tremors and anxiety.

Safety Profile

Mdly toxic by ingestion and subcutaneous routes. A skin and eye irritant. See also ETHYLENE GLYCOL. Experimental reproductive effects. Combustible when exposed to heat or flame. Incompatible with oxidizing materials. To fight fire, use foam, alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.

Safety

Butylene glycol is used in a wide variety of cosmetic formulations and is generally regarded as a relatively nontoxic material. It is mildly toxic by oral and subcutaneous routes.
In topical preparations, butylene glycol is regarded as minimally irritant. Butylene glycol can cause allergic contact dermatitis, with local sensitivity reported in patch tests. Some local irritation is produced on eye contact.
LD50 (guinea pig, oral): 11.0 g/kg
LD50 (mouse, oral): 12.98 g/kg
LD50 (rat, oral): 18.61 g/kg
LD50 (rat, SC): 20.0 g/kg

Carcinogenicity

There were no tumors found in the 2-year feeding studies on dogs and rats . Thus, it appears that 1,3-butanediol is not carcinogenic.

storage

Butylene glycol is hygroscopic and should be stored in a well-closed container in a cool, dry, well-ventilated place. When heated to decomposition, butylene glycol emits acrid smoke and irritating fumes.

Incompatibilities

Butylene glycol is incompatible with oxidizing reagents.

Regulatory Status

GRAS listed. Included in the FDA Inactive Ingredients Database (transdermal patches). Included in licensed medicines in the UK (topical gel patches/medicated plasters).

1,3-Butanediol Preparation Products And Raw materials

Raw materials

PROPYLENE Butyraldehyde ALDOL

Preparation Products

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1,3-Butanediol Suppliers

Americas 1 Australia 2 Austria 1 Belgium 4 Brazil 1 Canada 3 CHINA 436 Europe 5 France 4 Germany 30 India 33 Italy 1 Japan 17 Mexico 1 Philippines 1 Slovakia 1 South Korea 2 Spain 2 Switzerland 3 The Netherlands 4 Ukraine 2 United Kingdom 11 United States 71 Global 636
Connect Chemicals GmbH
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+49 2102 2077 19
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+49 2102 2077 40
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Martin.Klapper@connectchemicals.com
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View Lastest Price from 1,3-Butanediol manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
1,3-butylene glycol 107-88-0
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-04-22
Hebei Saisier Technology Co., LTD
Product
1,3-Butanediol 107-88-0
Price
US $6.00/KG
Min. Order
1KG
Purity
More than 99%
Supply Ability
2000KG/Month
Release date
2024-04-15
Hebei Mujin Biotechnology Co.,Ltd
Product
1,3-Butanediol 107-88-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-07

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