ChemicalBook > CAS DataBase List > 1-N-Cbz-4-cyanopiperidine

1-N-Cbz-4-cyanopiperidine

Product Name
1-N-Cbz-4-cyanopiperidine
CAS No.
161609-84-3
Chemical Name
1-N-Cbz-4-cyanopiperidine
Synonyms
BUTTPARK 93\50-50;1-Z-4-cyanopiperidine;1-CBZ-4-CYANOPIPERIDINE;N-CBZ-4-cyanopiperidine;1-N-CBZ-4-CYANO-PIPERIDINE;1-N-Cbz-4-cycano-piperidine;1-N-CBZ-PIPERIDINE-4-CARBONITRILE;4-Cyanopiperidine, N-CBZ protected;BENZYL-4-CYANOPIPERIDINE-1-CARBOXYLATE;4-CYANO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
CBNumber
CB7763001
Molecular Formula
C14H16N2O2
Formula Weight
244.29
MOL File
161609-84-3.mol
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1-N-Cbz-4-cyanopiperidine Property

Boiling point:
416.5±45.0 °C(Predicted)
Density 
1.18±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-3.13±0.40(Predicted)
Appearance
White to off-white Solid
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Safety

HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
B194155
Product name
Benzyl4-cyanopiperidine-1-carboxylate
Packaging
250mg
Price
$55
Updated
2021/12/16
AK Scientific
Product number
J56774
Product name
1-N-Cbz-4-Cyanopiperidine
Packaging
5g
Price
$55
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140315
Product name
Benzyl 4-cyanopiperidine-1-carboxylate
Packaging
5G
Price
$167
Updated
2021/12/16
AK Scientific
Product number
W3511
Product name
1-N-Cbz-4-Cyanopiperidine
Packaging
25g
Price
$254
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140315
Product name
Benzyl 4-cyanopiperidine-1-carboxylate
Packaging
10g
Price
$290
Updated
2021/12/16
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1-N-Cbz-4-cyanopiperidine Chemical Properties,Usage,Production

Synthesis

167757-45-1

161609-84-3

General procedure for the synthesis of 1-N-Cbz-4-cyanopiperidine from 1-Cbz-piperidine-4-carboxamide: 1-Cbz-piperidine-4-carboxamide (1.0 mmol) and triethylamine (Et3N, 1.5 mmol) were dissolved in ethyl acetate (EtOAc, 1 mL, 1 M) at room temperature. Subsequently, XtalFluor-E (1.1 mmol) was added in batches. The reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, the reaction was quenched with saturated sodium bicarbonate (NaHCO3) solution. Next, the reaction mixture was washed with aqueous sodium carbonate (Na2CO3) solution and extracted with dichloromethane (CH2Cl2, 2 × 10 mL). The organic layers were combined, washed sequentially with water and brine, dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure to give the crude product. If necessary, the crude product can be purified by fast column chromatography.

References

[1] Synthesis (Germany), 2015, vol. 47, # 23, p. 3758 - 3766

1-N-Cbz-4-cyanopiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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161609-84-3, 1-N-Cbz-4-cyanopiperidineRelated Search:

Benzyl chloride RESMETHRIN Benzyl benzoate Sodium cyanoborohydride Benzyl carbamate Cyanoacetic acid Benzyl chloroformate ETHYL 2-CYANOACRYLATE Benzyl alcohol Benzyl nicotinate 4-Cyanopiperidine Methylene dithiocyanate Benzyl formate Tris(trimethylsilyl)phosphate Haloperidol Benzyl Piperidine Diphenoxylate

  • BENZYL-4-CYANOPIPERIDINE-1-CARBOXYLATE
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  • 4-CYANO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
  • 1-CBZ-4-CYANOPIPERIDINE
  • 1-N-CBZ-4-CYANO-PIPERIDINE
  • 1-N-CBZ-PIPERIDINE-4-CARBONITRILE
  • 1-N-Cbz-4-cycano-piperidine
  • 1-Piperidinecarboxylic acid, 4-cyano-, phenylmethyl ester
  • N-CBZ-4-cyanopiperidine
  • 4-Cyanopiperidine, N-CBZ protected
  • Benzyl 4-cyanopiperidine-1-carboxylate, 1-[(Benzyloxy)carbonyl]-4-cyanopiperidine, 1-[(Benzyloxy)carbonyl]piperidine-4-carbonitrile
  • 1-Z-4-cyanopiperidine
  • 161609-84-3