Cefmenoxime
- Product Name
- Cefmenoxime
- CAS No.
- 65085-01-0
- Chemical Name
- Cefmenoxime
- Synonyms
- CMX;SCE 1365;AB 50912;CEFMENOXIME;Cefotaxime Isomer;Cefmenoxime USP/EP/BP;7β-[[(Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazole-5-yl)thio]methyl]cepham-3-ene-4-carboxylic acid;(6R,7R)-7-[[(Z)-(2-Aminothiazol-4-yl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;(6R,7R)-7α-[2-(2-Amino-4-thiazolyl)-2-[(Z)-methoxyimino]acetylamino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;[6R-[6α，7β(Z)]]-7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-y1)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oet-2-ene-2-carboxylic acid
- CBNumber
- CB7771510
- Molecular Formula
- C16H17N9O5S3
- Formula Weight
- 511.56
- MOL File
- 65085-01-0.mol
Cefmenoxime Property
- Density
- 1.96±0.1 g/cm3(Predicted)
- pka
- 2.61±0.50(Predicted)
- CAS DataBase Reference
- 65085-01-0(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- C242838
- Product name
- Cefmenoxime
- Packaging
- 10mg
- Price
- $580
- Updated
- 2021/12/16
- Product number
- C242838
- Product name
- Cefmenoxime
- Packaging
- 25mg
- Price
- $1155
- Updated
- 2021/12/16
- Product number
- API0007249
- Product name
- CEFMENOXIME
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $909.56
- Updated
- 2021/12/16
- Product number
- 2848
- Product name
- Cefmenoxime
- Packaging
- 25mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 2848
- Product name
- Cefmenoxime
- Packaging
- 100mg
- Price
- $95
- Updated
- 2021/12/16
Cefmenoxime Chemical Properties,Usage,Production
Originator
Tacef,Takeda,W. Germany,1983
Uses
Cefmenoxime (cas# 65085-01-0) is a compound useful in organic synthesis.
Uses
Antibacterial.
Definition
ChEBI: A third-generation cephalosporin antibiotic, bearing a 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino group at the 7beta-position and a [(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl group at the 3-position.
Manufacturing Process
7β-[α-Methoxyimino-α-(2-aminothiazol-4-yl)acetamido]cephalosporanicacid trifluoroacetic acid salt is dissolved in a solution of 272 mg of 1-methyl-5- mercapto-1H-tetrazole, 555 mg of sodium bicarbonate and 68 mg of triethylbenzylammonium bromide in 10 ml of water. The solution is heated at 60°C in nitrogen atmosphere for 6 hours. After cooling, the reaction solution is passed through a column of Amberlite XAD-2 and eluted with water and then with 2.5% ethanol. The procedure yields sodium 7β-[α-methoxyimino-α- (2-aminothiazol-4-yl)acetamido]-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-3- cephem-4-carboxylate, MP 174°C to 175°C (decomposition).
brand name
Cefmax (TAP).
Therapeutic Function
Antibacterial
Antimicrobial activity
A semisynthetic cephalosporin supplied as the hydrochloride.
Its activity is very similar to that of cefotaxime. A
500 mg intramuscular injection achieves a plasma concentration
of 15 mg/L after 40 min. A concentration of 200 mg/L is
attained after intravenous administration of 1 g. The plasma
half-life is c. 1 h. Around 77% is protein bound. Probenecid
increases peak plasma levels and extends the plasma half-life
to 1.8 h. Therapeutic concentrations are achieved in CSF.
There is a degradation product with a long half-life (around
40 h), but 80–92% of the drug is recovered unchanged from
the urine. In patients with renal insufficiency, no significant
relation was found between creatinine clearance and peak
serum concentrations but there was a linear relationship
with plasma half-life and total body clearance. About 10%
of the dose appears in the feces, mostly extensively degraded,
possibly
by the fecal flora.
Toxicity, side effects and clinical use are those common to
group 4 cephalosporins.
Cefmenoxime Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Cefmenoxime manufacturers
- Product
- Cefmenoxime 65085-01-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10mt
- Release date
- 2024-10-30
- Product
- Cefmenoxime 65085-01-0
- Price
- US $30.00-20.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000000
- Release date
- 2023-10-31
- Product
- Cefmenoxime 65085-01-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-06-20