4-CHLORO-5-METHOXY-2-(METHYLSULFANYL)PYRIMIDINE
- Product Name
- 4-CHLORO-5-METHOXY-2-(METHYLSULFANYL)PYRIMIDINE
- CAS No.
- 87026-45-7
- Chemical Name
- 4-CHLORO-5-METHOXY-2-(METHYLSULFANYL)PYRIMIDINE
- Synonyms
- 4-Chloro-5-methoxy-2-(methylthio);5-methoxy-2-methylthio-4-chloropyrimidine;4-Chloro-5-methoxy-2-(methylthio)pyrimidine;Pyrimidine, 4-chloro-5-methoxy-2-(methylthio)-;4-CHLORO-5-METHOXY-2-(METHYLSULFANYL)PYRIMIDINE;4-Chloro-5-methoxy-2-(methylthio)pyrimidine ,97%
- CBNumber
- CB7781391
- Molecular Formula
- C6H7ClN2OS
- Formula Weight
- 190.65
- MOL File
- 87026-45-7.mol
4-CHLORO-5-METHOXY-2-(METHYLSULFANYL)PYRIMIDINE Property
- Melting point:
- 73-77°
- Boiling point:
- 285.5±20.0 °C(Predicted)
- Density
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.39±0.29(Predicted)
- Appearance
- Light yellow to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P330Rinse mouth.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- S217344
- Product name
- 4-CHLORO-5-METHOXY-2-METHYLSULFANYL-PYRIMIDINE
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $30.7
- Updated
- 2025/07/31
- Product number
- S217344
- Product name
- 4-CHLORO-5-METHOXY-2-METHYLSULFANYL-PYRIMIDINE
- Purity
- AldrichCPR
- Packaging
- 25mg
- Price
- $29.8
- Updated
- 2024/03/01
- Product number
- HCH0122025
- Product name
- 4-CHLORO-5-METHOXY-2-(METHYLSULFANYL)PYRIMIDINE
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $932.89
- Updated
- 2021/12/16
- Product number
- FC11181
- Product name
- 4-Chloro-5-methoxy-2-(methylthio)pyrimidine
- Packaging
- 1g
- Price
- $940
- Updated
- 2021/12/16
- Product number
- FC11181
- Product name
- 4-Chloro-5-methoxy-2-(methylthio)pyrimidine
- Packaging
- 2g
- Price
- $1504
- Updated
- 2021/12/16
4-CHLORO-5-METHOXY-2-(METHYLSULFANYL)PYRIMIDINE Chemical Properties,Usage,Production
Chemical Properties
White solid
Synthesis
1671-08-5
87026-45-7
The general procedure for the synthesis of 4-chloro-5-methoxy-2-(methylthio)pyrimidine from 5-methoxy-4-hydroxy-2-methylthiopyrimidine was as follows: 1. To a round-bottomed flask containing ethyl formate (6 mL, 0.062 mol) and ether (30 mL) in an ice-water bath was added Na (1.4 g, 0.062 mol), followed by dropwise addition of methyl 2-methoxyacetate (6.5 g, 0.062 mol). The reaction mixture was stirred for 4 hours at room temperature. 2. Upon completion of the reaction, the reaction was quenched by the addition of ice water (25 mL) and the aqueous phase was separated. 3. To the aqueous phase, S-methylisothiourea (5.6 g, 0.062 mol) and KOH (2.2 g, 0.062 mol) were added sequentially and the reaction was heated to 65 °C for 1 hour. 4. After cooling, the reaction mixture was neutralized with 37% HCl, the crude product was collected by vacuum filtration and recrystallized from 95% ethanol to give Intermediate 2 as white needle-like crystals (4.3 g, 40.1% yield). 5. Intermediate 2 (1.7 g, 0.01 mol) was slowly added to POCl3 (4.6 g, 0.03 mol) in an ice-water bath, and the reaction was heated to 80 °C for 1 hour. 6. After the reaction was completed, it was cooled to room temperature, neutralized with 25% ammonia, filtered the precipitated solid, recrystallized with petroleum ether and decolorized with activated carbon to obtain Intermediate 3 as a light yellow solid (1.8 g, 95.2% yield). 7. Intermediate 3 was dissolved in methanol (10 mL), 50% hydrazine hydrate solution (1.6 g, 0.015 mol) was added dropwise under an ice-water bath, and the reaction was heated to 50 °C. The reaction progress was monitored by TLC. 8. Upon completion of the reaction, the reaction was cooled, the solvent was removed under reduced pressure, and the solid was recrystallized from ethyl acetate and petroleum ether to afford 5-methoxy-2-(methylthio)pyrimidin-4-ylhydrazine (4,1.1 g, 96.2% yield).
References
[1] Letters in Drug Design and Discovery, 2016, vol. 13, # 4, p. 329 - 334
[2] Patent: WO2004/50640, 2004, A1. Location in patent: Page 22
[3] Patent: WO2007/88999, 2007, A1. Location in patent: Page/Page column 167
4-CHLORO-5-METHOXY-2-(METHYLSULFANYL)PYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
4-CHLORO-5-METHOXY-2-(METHYLSULFANYL)PYRIMIDINE Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 023-63225655 13320248848
- Fax
- 023-63225655QQ2366581735
- 2366581735@qq.com
- Country
- China
- ProdList
- 511
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 18066080842 13952020641
- Fax
- 025-58912720
- bamd@foxmail.com
- Country
- China
- ProdList
- 759
- Advantage
- 55
- Tel
- 021-021-021-31663258 13795219287
- Fax
- 021-31663258
- donghuanwen@126.com
- Country
- China
- ProdList
- 8816
- Advantage
- 58
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 15083
- Advantage
- 58
View Lastest Price from 4-CHLORO-5-METHOXY-2-(METHYLSULFANYL)PYRIMIDINE manufacturers
- Product
- 4-chloro-5-Methoxy-2-(Methylsulfanyl)pyriMidine 87026-45-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15