Mal-?PEG4-?propargyl
- Product Name
- Mal-?PEG4-?propargyl
- CAS No.
- 1262681-30-0
- Chemical Name
- Mal-?PEG4-?propargyl
- Synonyms
- Propargyl-PEG4-Mal;Mal-?PEG4-?propargyl;1-(3,6,9,12-Tetraoxapentadec-14-yn-1-yl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 1-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)-;1-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethyl]pyrrole-2,5-dione;1-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
- CBNumber
- CB78054749
- Molecular Formula
- C15H21NO6
- Formula Weight
- 311.33
- MOL File
- 1262681-30-0.mol
Mal-?PEG4-?propargyl Property
- Boiling point:
- 432.0±40.0 °C(Predicted)
- Density
- 1.190±0.06 g/cm3(Predicted)
- solubility
- good in water, DMF, DMSO
- form
- Oil
- pka
- -2.34±0.20(Predicted)
- color
- Colorless to light yellow
- Appearance
- yellow oil
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- BP-24402
- Product name
- Propargyl-PEG4-Maleimide
- Purity
- 95%
- Packaging
- 25mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- BP-24402
- Product name
- Propargyl-PEG4-Maleimide
- Purity
- 95%
- Packaging
- 100mg
- Price
- $380
- Updated
- 2021/12/16
- Product number
- AS108020
- Product name
- Mal-PEG4-Propargyl
- Purity
- 94%
- Packaging
- 250mg
- Price
- $787
- Updated
- 2021/12/16
Mal-?PEG4-?propargyl Chemical Properties,Usage,Production
Description
Propargyl-PEG4-Maleimide has a propargyl group and a maleimide group. The propargyl group reacts with azide compounds or biomolecules under the catalyzation of copper in Click Chemistry reactions. The maleimide group enables the formation of a covalent bond with biomolecules containing a thiol group.
Uses
Mal-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Mal-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Mal-?PEG4-?propargyl Preparation Products And Raw materials
Raw materials
Preparation Products
Mal-?PEG4-?propargyl Suppliers
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View Lastest Price from Mal-?PEG4-?propargyl manufacturers
- Product
- MAL-PEG4-propargyl 1262681-30-0
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1g/bottle, 10g/bottle, 100g/bottle
- Release date
- 2026-02-03
- Product
- Mal-PEG4-propargyl 1262681-30-0
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-27