Volagidemab

Product Name: Volagidemab
CAS No.: 1233956-13-2
Chemical Name: Volagidemab
Synonyms: Volagidemab;Volagidemab (anti-GCGR);Research Grade Volagidemab;Research Grade Volagidemab (DHE51801)
CBNumber: CB78081136
Formula Weight: 0
MOL File: Mol file

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Volagidemab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Volagidemab Chemical Properties,Usage,Production

Uses

Volagidemab is an antagonistic glucagon receptor (GCGR) monoclonal antibody (mAb). Volagidemab can be used in the research of type 1 diabetes (T1D)[1][2].

in vivo

Volagidemab (5 mg/kg, s.c.) suppresses type 1 diabetes phenotype in Alloxan-induced diabetic mice^[2].

Animal Model:	Alloxan-induced diabetic mice ^[2]
Dosage:	5 mg/kg
Administration:	Subcutaneous injection (s.c.)
Result:	Reduced phosphorylated CREB protein and PEPCK protein expression to nondiabetic levels.

References

[1] Pettus J, et al. Glucagon receptor antagonist volagidemab in type 1 diabetes: a 12-week, randomized, double-blind, phase 2 trial. Nat Med. 2022 Oct;28(10):2092-2099. DOI:10.1038/s41591-022-02011-x
[2] Wang MY, et al. Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway. Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2503-8. DOI:10.1073/pnas.1424934112

Volagidemab Preparation Products And Raw materials

Raw materials

Preparation Products

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Volagidemab Suppliers

China 16 Global 16

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1233956-13-2, VolagidemabRelated Search:

Anselamimab Fidasimtamab Gremubamab bexxar Biciromab Vibecotamab Mipasetamab Sibrotuzumab Galegenimab Anatumomab

Volagidemab

Research Grade Volagidemab (DHE51801)

Research Grade Volagidemab

Volagidemab (anti-GCGR)

1233956-13-2