A 205804
- Product Name
- A 205804
- CAS No.
- 251992-66-2
- Chemical Name
- A 205804
- Synonyms
- CS-635;A 205804;A-205804;A 205804;A 205804 USP/EP/BP;A205804;A 205804;A-205804;IKK-16 (IKK Inhibitor VII);4-(p-tolylthio)thieno[2,3-c]pyridine-2-carboxamide;4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide;Thieno[2,3-c]pyridine-2-carboxamide, 4-[(4-methylphenyl)thio]-;4-[(4-methylphenyl)sulfanyl]thieno[2,3-c]pyridine-2-carboxam...
- CBNumber
- CB7838925
- Molecular Formula
- C15H12N2OS2
- Formula Weight
- 300.4
- MOL File
- 251992-66-2.mol
A 205804 Property
- Melting point:
- 198-199℃
- Boiling point:
- 581.3±45.0 °C(Predicted)
- Density
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- ≥30 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- pka
- 15.12±0.30(Predicted)
- form
- powder to crystal
- color
- White to Orange to Green
Safety
- HS Code
- 2934.99.9001
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T3498
- Product name
- 4-(p-Tolylthio)thieno[2,3-c]pyridine-2-carboxamide
- Purity
- >95.0%(HPLC)
- Packaging
- 25mg
- Price
- $178
- Updated
- 2024/03/01
- Product number
- T3498
- Product name
- 4-(p-Tolylthio)thieno[2,3-c]pyridine-2-carboxamide
- Purity
- >95.0%(HPLC)
- Packaging
- 100mg
- Price
- $488
- Updated
- 2024/03/01
- Product number
- 21252
- Product name
- A-205804
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 21252
- Product name
- A-205804
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 21252
- Product name
- A-205804
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $130
- Updated
- 2024/03/01
A 205804 Chemical Properties,Usage,Production
Description
A-205804 is a potent inhibitor of E-selectin and ICAM-1 expression in human vascular endothelial cells stimulated with TNF-α (IC50s = 20 and 25 nM, respectively). It does not block expression of VCAM-1 (IC50 > 1,000 nM).
Uses
4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide is a reagent used in the preparation of selective inhibitors of cell adhesion molecule expression in human endothelial cells.
Definition
ChEBI: 4-[(4-methylphenyl)thio]-2-thieno[2,3-c]pyridinecarboxamide is an aryl sulfide.
Biological Activity
Selective inhibitor of E-selectin and ICAM-1 expression (IC 50 values are 20, 25 and > 1000 nM for TNF- α -induced E-selectin, ICAM-1 and VCAM-1 expression respectively). Effective inhibitor of cell-cell adhesion in an in vitro flow experiment.
storage
Store at +4°C
References
[1]. stewart, a.o., et al., discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. selective inhibition of icam-1 and e-selectin expression. j med chem, 2001. 44(6): p. 988-1002.
[2]. chang, c.z., et al., valproic acid attenuates intercellular adhesion molecule-1 and e-selectin through a chemokine ligand 5 dependent mechanism and subarachnoid hemorrhage induced vasospasm in a rat model. j inflamm (lond), 2015. 12: p. 27.
[3]. zhu, g.d., et al., selective inhibition of icam-1 and e-selectin expression in human endothelial cells. 2. aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at c-2 carbamides. j med chem, 2001. 44(21): p. 3469-87.
[4]. zhu, g.d., et al., synthesis and mode of action of (125)i- and (3)h-labeled thieno[2,3-c]pyridine antagonists of cell adhesion molecule expression. j org chem, 2002. 67(3): p. 943-8.
A 205804 Preparation Products And Raw materials
Raw materials
Preparation Products
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