A 205804

ChemicalBook > CAS DataBase List > A 205804

Product Name: A 205804
CAS No.: 251992-66-2
Chemical Name: A 205804
Synonyms: CS-635;A 205804;A-205804;A 205804;A 205804 USP/EP/BP;A205804;A 205804;A-205804;IKK-16 (IKK Inhibitor VII);4-(p-tolylthio)thieno[2,3-c]pyridine-2-carboxamide;4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide;Thieno[2,3-c]pyridine-2-carboxamide, 4-[(4-methylphenyl)thio]-;4-[(4-methylphenyl)sulfanyl]thieno[2,3-c]pyridine-2-carboxam...
CBNumber: CB7838925
Molecular Formula: C15H12N2OS2
Formula Weight: 300.4
MOL File: 251992-66-2.mol

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A 205804 Property

Melting point:: 198-199℃
Boiling point:: 581.3±45.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: ≥30 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
pka: 15.12±0.30(Predicted)
form: powder to crystal
color: White to Orange to Green

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Safety

HS Code: 2934.99.9001

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T3498
Product name: 4-(p-Tolylthio)thieno[2,3-c]pyridine-2-carboxamide
Purity: >95.0%(HPLC)
Packaging: 25mg
Price: $178
Updated: 2024/03/01

TCI Chemical

Product number: T3498
Product name: 4-(p-Tolylthio)thieno[2,3-c]pyridine-2-carboxamide
Purity: >95.0%(HPLC)
Packaging: 100mg
Price: $488
Updated: 2024/03/01

Cayman Chemical

Product number: 21252
Product name: A-205804
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21252
Product name: A-205804
Purity: ≥95%
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 21252
Product name: A-205804
Purity: ≥95%
Packaging: 10mg
Price: $130
Updated: 2024/03/01

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A 205804 Chemical Properties,Usage,Production

Description

A-205804 is a potent inhibitor of E-selectin and ICAM-1 expression in human vascular endothelial cells stimulated with TNF-α (IC₅₀s = 20 and 25 nM, respectively). It does not block expression of VCAM-1 (IC₅₀ > 1,000 nM).

Uses

4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide is a reagent used in the preparation of selective inhibitors of cell adhesion molecule expression in human endothelial cells.

Definition

ChEBI: 4-[(4-methylphenyl)thio]-2-thieno[2,3-c]pyridinecarboxamide is an aryl sulfide.

Biological Activity

Selective inhibitor of E-selectin and ICAM-1 expression (IC 50 values are 20, 25 and > 1000 nM for TNF- α -induced E-selectin, ICAM-1 and VCAM-1 expression respectively). Effective inhibitor of cell-cell adhesion in an in vitro flow experiment.

storage

Store at +4°C

References

[1]. stewart, a.o., et al., discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. selective inhibition of icam-1 and e-selectin expression. j med chem, 2001. 44(6): p. 988-1002.
[2]. chang, c.z., et al., valproic acid attenuates intercellular adhesion molecule-1 and e-selectin through a chemokine ligand 5 dependent mechanism and subarachnoid hemorrhage induced vasospasm in a rat model. j inflamm (lond), 2015. 12: p. 27.
[3]. zhu, g.d., et al., selective inhibition of icam-1 and e-selectin expression in human endothelial cells. 2. aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at c-2 carbamides. j med chem, 2001. 44(21): p. 3469-87.
[4]. zhu, g.d., et al., synthesis and mode of action of (125)i- and (3)h-labeled thieno[2,3-c]pyridine antagonists of cell adhesion molecule expression. j org chem, 2002. 67(3): p. 943-8.

A 205804 Preparation Products And Raw materials

Raw materials

Preparation Products

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A 205804 Suppliers

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251992-66-2, A 205804Related Search:

p-Tolualdehyde 2-Methylpropanedioic acid p-Toluenethiol Poly(methyl methacrylate) (S)-(+)-Benzyl glycidyl ether Benzyl alcohol 4'-Hydroxyacetophenone Selumetinib Ki16198 Nintedanib Raltitrexed TAK875 PLX4032 Thieno[2,3-c]pyridine, 2-methyl- (9CI) A 205804

A 205804

4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide

CS-635

A205804;A 205804;A-205804

A 205804,4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxaMide

4-(p-tolylthio)thieno[2,3-c]pyridine-2-carboxamide

Thieno[2,3-c]pyridine-2-carboxamide, 4-[(4-methylphenyl)thio]-

4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide A-205804

IKK-16 (IKK Inhibitor VII)

A-205804;A 205804

A 205804 USP/EP/BP

4-[(4-methylphenyl)sulfanyl]thieno[2,3-c]pyridine-2-carboxam...

Inhibitor,molecules,Adhesion,ICAM-1,A205804,E-selectin,A-205804,Integrin,A 205804,inhibit

251992-66-2

Inhibitors