ChemicalBook > CAS DataBase List > 5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL

5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL

Product Name
5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL
CAS No.
213261-59-7
Chemical Name
5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL
Synonyms
RITA;ZNF331;ZNF361;ZNF463;PSEC0043;RITA, >99%;RITA, >=98%;RITA (NSC 652287);p53 Activator III;RITA, p53 activator
CBNumber
CB7839285
Molecular Formula
C14H12O3S2
Formula Weight
292.37
MOL File
213261-59-7.mol
More
Less

5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL Property

Melting point:
160 °C
Boiling point:
464.9±40.0 °C(Predicted)
Density 
1.396±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
Soluble in DMSO (up to 20 mg/ml)
form 
Crystalline solid
pka
13.43±0.10(Predicted)
color 
Yellow
Sensitive 
Light Sensitive
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
More
Less

Safety

HS Code 
29321900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
506149
Product name
p53 Activator III, RITA
Packaging
1mg
Price
$146
Updated
2025/07/31
TCI Chemical
Product number
F1235
Product name
RITA
Packaging
5MG
Price
$107
Updated
2025/07/31
TCI Chemical
Product number
F1235
Product name
RITA
Packaging
25MG
Price
$373
Updated
2025/07/31
Cayman Chemical
Product number
10006426
Product name
RITA
Purity
≥98%
Packaging
1mg
Price
$64
Updated
2024/03/01
Cayman Chemical
Product number
10006426
Product name
RITA
Purity
≥98%
Packaging
5mg
Price
$132
Updated
2024/03/01
More
Less

5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL Chemical Properties,Usage,Production

Description

RITA (reactivation of p53 and induction of tumor cell apoptosis, 213261-59-7) binds to p53 (Kd = 1.5 nM), changing its conformation, preventing it from binding to HDM2 and preventing its proteasomal degradation.1 It also weakly (computed Kd = 22 μM) binds HDM2 in the cleft that contacts the p53 transactivation domain.2 Its restoration of mutant p53 function depends on eIF2α phosphorylation, and it induces apoptosis via p53-dependent and -independent (JNK/SAPK/p38; protein translation) pathways.3-5 Induces senescence in head and neck cancer cells.6

Uses

NSC 652287, a DNA damaging agent. It induces p53 tumor suppressor protein.

Uses

A cell-permeable, p53-targeting, tricyclic thiophene derivative

Definition

ChEBI: [5-[5-[5-(hydroxymethyl)-2-thiophenyl]-2-furanyl]-2-thiophenyl]methanol is a member of thiophenes.

Biological Activity

Anti-tumor agent that binds wild-type p53 (K d = 1.5 nM) preventing p53-MDM2 (HDM2) interaction. Induces p53 accumulation and stimulates apoptosis in tumor cell lines expressing wild-type p53 in vitro and in vivo .

in vitro

a number of cell lines showed a striking differential sensitivity to nsc 652287 when compared with the other cell lines in the panel, with gi50 values of 10–60 nm. the compound was found to decrease the initial number of cells by 50% (lc50) at a concentration of 100 nm in the a-498 cell line, compared with ~100 mm for the majority of the tumor cell lines. the a-498 and tk-10 cell lines were particularly sensitive to nsc 652287-induced cytotoxicity compared with achn and uo-31 cell lines [1].

in vivo

nsc 652287 was evaluated against a-498 tumor cell xenografts grown subcutaneously in nude mice. when nsc 652287 was administered twice a day, all three doses resulted in complete tumor regression in 100% of the treated mice by the end of the third treatment period. the tumors did not regrow during the remaining 40 days of the study, and no gross evidence of toxicity was observed. studies with xenografts derived from other sensitive cell lines including the renal caki-1, melanoma uacc-257, ovarian ovcar-5, and colon hcc-2998, showed moderate or minimal in vivo activity [2].

IC 50

2 nm and 20 nm for a-498 and tk-10, respectively

storage

Store at -20°C

References

[1] NATALIA ISSAEVA. Small molecule RITA binds to p53, blocks p53–HDM-2 interaction and activates p53 function in tumors[J]. Nature Medicine, 2004, 10 12: 1321-1328. DOI:10.1038/nm1146
[2] ESPINOZA-FONSECA L M. Targeting MDM2 by the small molecule RITA: towards the development of new multi-target drugs against cancer.[C]//Vol. 2. 2005: 38. DOI:10.1186/1742-4682-2-38
[3] JOHANNES RISTAU. RITA requires eIF2α-dependent modulation of mRNA translation for its anti-cancer activity[J]. Cell Death & Disease, 2019, 70 1. DOI:10.1038/s41419-019-2074-3
[4] CAROLYN Y ZHAO. Rescue of the apoptotic-inducing function of mutant p53 by small molecule RITA.[J]. Cell Cycle, 2010, 9 9: 1847-1855. DOI:10.4161/cc.9.9.11545
[5] A WEILBACHER. RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38[J]. Cell Death & Disease, 2014, 5 7: e1318-e1318. DOI:10.1038/cddis.2014.284
[6] HUI-CHING CHUANG. The p53-reactivating small molecule RITA induces senescence in head and neck cancer cells.[J]. PLoS ONE, 2014: e104821. DOI:10.1371/journal.pone.0104821

5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL Suppliers

Americas 1 Canada 1 China 126 Europe 1 Germany 1 India 2 Japan 2 United Kingdom 1 United States 25 Global 160
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Jinan Trio PharmaTech Co., Ltd.
Tel
0531-88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com
Country
China
ProdList
1856
Advantage
62
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4720
Advantage
55
CEG Chemical Science&Technology Co., Ltd.
Tel
Mobile:13665161512
Fax
+86-510-68873513
Country
China
ProdList
1785
Advantage
58
GIHI CHEMICALS CO.,LTD
Tel
0086-571-86217390
Fax
0086-571-86217391
Email
Sales@gihichem.com
Country
China
ProdList
860
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Shanghai JiYi Biotechnology Co. Ltd.
Tel
13621943973
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1166
Advantage
55
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9858
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4768
Advantage
55
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
6687
Advantage
55
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862，442785678，326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
Country
China
ProdList
9627
Advantage
58
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9923
Advantage
55
Lancrix Chemicals
Tel
86-21-50817262
Fax
86-21-57712035
Email
sales@lancrix.com
Country
China
ProdList
1502
Advantage
55
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
8011
Advantage
55
Chengdu Huachun Technology Co., Ltd
Tel
400-1166-196 15982826727
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
12475
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29759
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Medi-tech Bioscientific Co., Ltd.
Tel
0519-83246372 13585352506
Fax
0519-83246372
Country
China
ProdList
1844
Advantage
58
Shanghai Kangman Biological Technology Co., Ltd.
Tel
18800375331
Fax
021-50908862
Email
kangmansales@163.com
Country
China
ProdList
7570
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28785
Advantage
58
Shanghai BaiShun Biological Technology Co., Ltd
Tel
021-37581181
Fax
021-57456066
Email
sales@chem-mall.com
Country
China
ProdList
10330
Advantage
58
Shanghai Zhen Li Biological Technology Co., Ltd
Tel
021-16621358918; 18516310516
Fax
13045646768
Email
zhenlipharma888@163.com
Country
China
ProdList
19035
Advantage
58
Aikon International Limited
Tel
025-58851090 15955137747
Fax
(6)02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15949
Advantage
58
UHN Shanghai Research & Development Co., Ltd.
Tel
021-58958002 18930822973
Fax
021-58958618
Email
sales@uhnshanghai.com
Country
China
ProdList
1984
Advantage
58
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3277
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-037163312495,13303845143 13303845143
Fax
QQ3001379618
Email
3001379618@qq.com
Country
China
ProdList
10267
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4696
Advantage
58
Taizhou Crene Biotechnology Co. Ltd.
Tel
+86-0576-88813233 +86-13396860566
Email
sales@pharm-intermediates.com
Country
China
ProdList
1991
Advantage
58
Henan Alpha Chemical Co., Ltd.
Tel
0371-55055611 18137792234
Fax
QQ：3002694073
Email
3002694073@qq.com
Country
China
ProdList
9987
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
20284
Advantage
58
Hubei Jusheng Technology Co.,Ltd.
Tel
18871490254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28172
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3934
Advantage
58
More
Less

View Lastest Price from 5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL manufacturers

Career Henan Chemical Co
Product
5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL 213261-59-7
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-09-03

213261-59-7, 5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOLRelated Search:

3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Pomalidomide Dequalinium chloride Pifithrin-α (PFTα) Bortezomib GDC-0068 MG-132 Dabrafenib BEZ235 (NVP-BEZ235, Dactolisib) 2-Thiophenemethanol 5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL [5-(2-Furyl)thien-2-yl]methanol 2-(2-THIENYL)FURAN 97

  • 5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL
  • p53 Activator III
  • RITA (NSC 652287)
  • (5,5'-(furan-2,5-diyl)bis(thiophene-5,2-diyl))diMethanol
  • 2-Thiophenemethanol, 5,5'-(2,5-furandiyl)bis-
  • 5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol RITA (NSC 652287)
  • 5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol NSC 652287
  • NSC 652287 5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol
  • ANTI-ZNF331 (N-TERM) antibody produced in rabbit
  • Zinc finger protein 331
  • ZNF331
  • ZNF361
  • ZNF463
  • p53 Activator III, RITA
  • [5-[5-[5-(hydroxymethyl)thiophen-2-yl]furan-2-yl]thiophen-2-yl]methanol
  • RITA
  • RITA, >99%
  • RITA, >=98%
  • p53 Activator III, RITA - CAS 213261-59-7 - Calbiochem
  • NSC-652287; NSC 652287
  • 2,5-Bis(5-hydroxymethyl-2-thienyl)furan
  • 5,5'-(2,5-FURANDIYL)BIS-2-THIOPHENEMETHANOL USP/EP/BP
  • RITA, p53 activator
  • RITA, 10 mM in DMSO
  • PSEC0043
  • (furan-2,5-diylbis(thiophene-5,2-diyl))dimethanol
  • 213261-59-7
  • Inhibitor
  • Inhibitors