4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE

Product Name: 4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE
CAS No.: 2770-01-6
Chemical Name: 4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE
Synonyms: 4-CHLORO-1-H-IMIDAZO[4;4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE;3H-IMidazo[4,5-c]pyridine, 4-chloro-;4-Chloro-1H-imidazo[4,5-c]pyridine 98%;4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE ISO 9001：2015 REACH;4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE
CBNumber: CB7840366
Molecular Formula: C6H4ClN3
Formula Weight: 153.57
MOL File: 2770-01-6.mol

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4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE Property

Melting point:: 179-181 °C
Boiling point:: 455.4±25.0 °C(Predicted)
Density: 1.531±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated)
form: Solid
pka: 7.93±0.40(Predicted)
color: Pale Beige to Pale Brown
InChI: InChI=1S/C6H4ClN3/c7-6-5-4(1-2-8-6)9-3-10-5/h1-3H,(H,9,10)
InChIKey: DHJMLXBBZRWBPW-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=CC2N=CNC1=2

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C367595
Product name: 4-Chloro-1H-imidazo[4,5-c]pyridine
Packaging: 10g
Price: $1185
Updated: 2021/12/16

Matrix Scientific

Product number: 070335
Product name: 4-Chloro-1H-imidazo[4,5-c]pyridine
Purity: 95%
Packaging: 5g
Price: $1234
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0027369
Product name: 4-CHLORO-1H-IMIDAZO[4,5-C]PYRIDINE
Purity: 95.00%
Packaging: 1G
Price: $1783.32
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0027369
Product name: 4-CHLORO-1H-IMIDAZO[4,5-C]PYRIDINE
Purity: 95.00%
Packaging: 5G
Price: $5227.53
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC32403
Product name: 4-Chloro-1H-imidazo[4,5-c]pyridine
Packaging: 100mg
Price: $50
Updated: 2021/12/16

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4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE Chemical Properties,Usage,Production

Uses

4-Chloro-1H-imidazo[4,5-c]pyridine is used as a reagent in the synthesis of 3-bromo-3-deazaneplanocin and 3-bromo-3-deazaaristeromycin, compounds which exhibit antiviral activity.

Synthesis

91184-02-0

2770-01-6

The general procedure for the synthesis of 4-chloroimidazo[4,5-C]pyridine using the compound (CAS: 91184-02-0) as starting material was as follows: compound 3 (255 mg, 1.88 mmol) was dissolved in 10 mL of phosphorus oxytrichloride (POCl3), and the reaction was stirred for 3 hr at 110 °C until the reaction solution became clear. Upon completion of the reaction, the excess phosphorous trichloride was removed under vacuum. Subsequently, ice water was added to the reaction mixture, the pH was adjusted to about 9 by slowly adding ammonia dropwise, and an equal volume of methanol (MeOH) was added. At this point, a precipitate appeared in the reaction mixture and the precipitate was collected by filtration. The filtrate was adsorbed on silica gel and purified by silica gel column chromatography, the eluent being a mixture of ethyl acetate (EA) and 5% methanol (MeOH), resulting in the target product 4 in 83% yield. The results of high-resolution mass spectrometry (HRMS-ESI) analysis were as follows: m/z calculated value (C6H5ClN3 [M+H]+) was 154.0166, and the measured value was 154.0171.

References

[1] European Journal of Medicinal Chemistry, 2018, vol. 148, p. 384 - 396
[2] ChemMedChem, 2013, vol. 8, # 6, p. 985 - 993
[3] Patent: US5057517, 1991, A

4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE Suppliers

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View Lastest Price from 4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE manufacturers

Dideu Industries Group Limited

Product: 4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE 2770-01-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-27

2770-01-6, 4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINERelated Search:

4-Chloro-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline 4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE 3-chloroimidazo[1,2-a]pyridine-8-carboxylic acid 7-chloro-1H-imidazo[4,5-b]pyridine 6-bromo-8-chloroimidazo[1,2-a]pyridine 6-CHLOROIMIDAZO[1,2-A]PYRIDINE 5-CHLORO-3H-IMIDAZO[4,5-B]PYRIDINE 8-CHLORO-6-(TRIFLUOROMETHYL)IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID 4-Chloroimidazole 4-chloro-2-methyl-1H-imidazo[4,5-c]pyridine 2-BROMO-4-CHLORO-1,6-DIMETHYL-1H-IMIDAZO[4,5-C]PYRIDINE 2-BROMO-4-CHLORO-1-METHYL-1H-IMIDAZO[4,5-C]PYRIDINE 4-CHLORO-1-(2-DEOXY-BETA-D-ERYTHROPENTOFURANOSYL)-1H-IMIDAZO[4,5-C]PYRIDINE 4-Chloro-2-(3-chlorophenyl)-imidazo(4,5-c)pyridine 4-CHLORO-1-METHYL-1H-IMIDAZO[4,5-C]PYRIDINE 4-CHLORO-1,6-DIMETHYL-1H-IMIDAZO[4,5-C]PYRIDINE 2-(2-bromophenyl)-4-chloro-1H-imidazo[4,5-c]pyridine 8-CHLORO-6-(TRIFLUOROMETHYL)IMIDAZO[1,2-A]PYRIDINE

3H-IMidazo[4,5-c]pyridine, 4-chloro-

4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE

4-Chloro-1H-imidazo[4,5-c]pyridine 98%

4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE

4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE ISO 9001：2015 REACH

4-CHLORO-1-H-IMIDAZO[4

2770-01-6

2770-1-6

Heterocycle-Pyridine series