5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE

ChemicalBook > CAS DataBase List > 5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE

5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE

Product Name: 5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE
CAS No.: 874902-19-9
Chemical Name: 5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE
Synonyms: CS-752;LY 2183240;LY2183240 powder;LY-2183240 MN-25;LY2183240/LY-2183240;N,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide;5-(biphenyl-4-ylMethyl)-N,N-diMethyl-1H-tetrazole-1-carboxaMide;5-Biphenyl-4-ylmethyl-tetrazole-1-carboxylic acid dimethylamide;1H-Tetrazole-1-carboxamide, 5-([1,1′-biphenyl]-4-ylmethyl)-N,N-dimethyl-;5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE
CBNumber: CB7842012
Molecular Formula: C17H17N5O
Formula Weight: 307.35
MOL File: 874902-19-9.mol

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5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE Property

Melting point:: 87-88℃
Boiling point:: 506.1±53.0 °C(Predicted)
Density: 1.21
storage temp.: Sealed in dry,2-8°C
solubility: Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (up to 15 mg/ml).
pka: 0.01±0.10(Predicted)
form: White to off-white solid.
color: White
Stability:: Stable for 1 year as supplied. Solutions in DMSO of ethanol may be stored at -20°C for up to 1 month

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Safety

Hazard Codes: Xn
Risk Statements: 22

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10008663
Product name: LY2183240
Purity: ≥98%
Packaging: 1mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 10008663
Product name: LY2183240
Purity: ≥98%
Packaging: 5mg
Price: $252
Updated: 2024/03/01

Tocris

Product number: 2452
Product name: LY2183240
Purity: ≥98%(HPLC)
Packaging: 1
Price: $112
Updated: 2021/12/16

Tocris

Product number: 2452
Product name: LY2183240
Purity: ≥98%(HPLC)
Packaging: 10
Price: $237
Updated: 2021/12/16

TRC

Product number: L503140
Product name: LY2183240
Packaging: 250mg
Price: $790
Updated: 2021/12/16

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5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE Chemical Properties,Usage,Production

Description

LY-2183240 (874902-19-9) is highly potent inhibitor of cellular anandamide uptake (IC50 = 0.27nM1, 15nM2). LY-2183240 has also been found2-4 to be an inhibitor of fatty acid amide hydrolase (FAAH) – IC50 = 14nM4, diacylglycerol lipase (DAGL) and monoacylglycerol lipase (MAGL) – IC50 = 5.3 nM3.

Uses

LY2183240 is a potent inhibitor of FAAH activity, and the uptake and enzymatic hydrolysis of anandamide. Synthetic Cannabinoids

Definition

ChEBI: N,N-dimethyl-5-[(4-phenylphenyl)methyl]-1-tetrazolecarboxamide is a member of biphenyls.

Biological Activity

Novel and highly potent blocker of anandamide uptake (IC 50 = 270 pM). Inhibits fatty acid amide hydrolase (FAAH) activity (IC 50 = 12.4 nM). Following i.p. administration in rats, increases brain anandamide concentration and exerts antinociceptive effects in formalin model of pain.

References

1) Moore et al., (2005), Identification of a high-affinity binding site involved in the transport of endocannabinoids; Proc. Natl. Acad. Sci. USA, 102 17852 2) Ortar et al. (2008), Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: A critical revision; Eur. .J. Med. Chem., 43 62 3) Alexander and Cravatt (2006), The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases; J. Am. Chem. Soc., 128 9699 4) Dickason-Chesterfield et al. (2006), Pharmacological Characterization of Endocannabinoid Transport and Fatty Acid Amide Hydrolase Inhibitors; Cell. Mol. Neurobiol., 26 405

5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE Suppliers

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View Lastest Price from 5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE manufacturers

Qiuxian Baitai New Material Co., LTD

Product: LY2183240 powder 874902-19-9
Price: US $29.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500ton/Month
Release date: 2021-07-30

Career Henan Chemical Co

Product: N,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide 874902-19-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-09

874902-19-9, 5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDERelated Search:

Simvastatin EPA LY 171883 Zileuton 3,3',5,5'-Tetramethylbenzidine dihydrochloride Biphenyl Bifenthrin BIFENAZATE FIREMASTER BP-6 Thiamethoxam 5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE 1H-TETRAZOLE, 5-(P-METHYLBENZYL)-

5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE

LY 2183240

LY-2183240 MN-25

1H-Tetrazole-1-carboxamide, 5-([1,1′-biphenyl]-4-ylmethyl)-N,N-dimethyl-

5-Biphenyl-4-ylmethyl-tetrazole-1-carboxylic acid dimethylamide

N,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide

5-(biphenyl-4-ylMethyl)-N,N-diMethyl-1H-tetrazole-1-carboxaMide

LY2183240/LY-2183240

CS-752

LY2183240 powder

Inhibitor,brain,uptake,transport,hydrolases,Fatty acid amide hydrolase,LY2183240,Autophagy,LY 2183240,serine,anandamide,FAAH,inhibit,LY-2183240

5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE

874902-19-9