5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE
- Product Name
- 5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE
- CAS No.
- 874902-19-9
- Chemical Name
- 5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE
- Synonyms
- CS-752;LY 2183240;LY2183240 powder;LY-2183240 MN-25;LY2183240/LY-2183240;N,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide;5-(biphenyl-4-ylMethyl)-N,N-diMethyl-1H-tetrazole-1-carboxaMide;5-Biphenyl-4-ylmethyl-tetrazole-1-carboxylic acid dimethylamide;1H-Tetrazole-1-carboxamide, 5-([1,1′-biphenyl]-4-ylmethyl)-N,N-dimethyl-;5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE
- CBNumber
- CB7842012
- Molecular Formula
- C17H17N5O
- Formula Weight
- 307.35
- MOL File
- 874902-19-9.mol
5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE Property
- Melting point:
- 87-88℃
- Boiling point:
- 506.1±53.0 °C(Predicted)
- Density
- 1.21
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (up to 15 mg/ml).
- pka
- 0.01±0.10(Predicted)
- form
- White to off-white solid.
- color
- White
- Stability:
- Stable for 1 year as supplied. Solutions in DMSO of ethanol may be stored at -20°C for up to 1 month
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 10008663
- Product name
- LY2183240
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 10008663
- Product name
- LY2183240
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $252
- Updated
- 2024/03/01
- Product number
- 2452
- Product name
- LY2183240
- Purity
- ≥98%(HPLC)
- Packaging
- 1
- Price
- $112
- Updated
- 2021/12/16
- Product number
- 2452
- Product name
- LY2183240
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $237
- Updated
- 2021/12/16
- Product number
- L503140
- Product name
- LY2183240
- Packaging
- 250mg
- Price
- $790
- Updated
- 2021/12/16
5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE Chemical Properties,Usage,Production
Description
LY-2183240 (874902-19-9) is highly potent inhibitor of cellular anandamide uptake (IC50 = 0.27nM1, 15nM2). LY-2183240 has also been found2-4 to be an inhibitor of fatty acid amide hydrolase (FAAH) – IC50 = 14nM4, diacylglycerol lipase (DAGL) and monoacylglycerol lipase (MAGL) – IC50 = 5.3 nM3.
Uses
LY2183240 is a potent inhibitor of FAAH activity, and the uptake and enzymatic hydrolysis of anandamide. Synthetic Cannabinoids
Definition
ChEBI: N,N-dimethyl-5-[(4-phenylphenyl)methyl]-1-tetrazolecarboxamide is a member of biphenyls.
Biological Activity
Novel and highly potent blocker of anandamide uptake (IC 50 = 270 pM). Inhibits fatty acid amide hydrolase (FAAH) activity (IC 50 = 12.4 nM). Following i.p. administration in rats, increases brain anandamide concentration and exerts antinociceptive effects in formalin model of pain.
References
1) Moore et al., (2005), Identification of a high-affinity binding site involved in the transport of endocannabinoids; Proc. Natl. Acad. Sci. USA, 102 17852 2) Ortar et al. (2008), Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: A critical revision; Eur. .J. Med. Chem., 43 62 3) Alexander and Cravatt (2006), The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases; J. Am. Chem. Soc., 128 9699 4) Dickason-Chesterfield et al. (2006), Pharmacological Characterization of Endocannabinoid Transport and Fatty Acid Amide Hydrolase Inhibitors; Cell. Mol. Neurobiol., 26 405
5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE Suppliers
View Lastest Price from 5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE manufacturers
- Product
- LY2183240 powder 874902-19-9
- Price
- US $29.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500ton/Month
- Release date
- 2021-07-30
- Product
- N,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide 874902-19-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09