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Docetaxel

Product Name
Docetaxel
CAS No.
125354-16-7
Chemical Name
Docetaxel
Synonyms
CS-878;DOCETAXOL;Docetaxal;PNU 101383;10-Acetyltaxotere;MK-0431 phosphate;10-Acetyldocetaxel;Docetaxel impurity G;ACETYLDOCETAXEL, 10-;Paclitaxel Impurity 3
CBNumber
CB7842087
Molecular Formula
C45H55NO15
Formula Weight
849.93
MOL File
125354-16-7.mol
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Docetaxel Property

Melting point:
201-203 °C(Solv: methanol (67-56-1))
Boiling point:
901.4±65.0 °C(Predicted)
Density 
1.36±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
11.20±0.46(Predicted)
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
D494565
Product name
Docetaxal
Packaging
100mg
Price
$120
Updated
2021/12/16
TRC
Product number
D494565
Product name
Docetaxal
Packaging
1g
Price
$580
Updated
2021/12/16
Usbiological
Product number
163942
Product name
Docetaxal
Packaging
5mg
Price
$460
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0010442
Product name
10-ACETYLDOCETAXEL
Purity
95.00%
Packaging
10MG
Price
$477.75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA46386
Product name
10-Acetyl docetaxel
Packaging
50mg
Price
$1800
Updated
2021/12/16
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Docetaxel Chemical Properties,Usage,Production

Uses

Docetaxal is an impurity of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel (P132500). Docetaxel is an antimitotic agent that promotes the assembly of micro-tubules and inhibits their de -polymerization to free tubulin.

Uses

Docetaxal (Docetaxel EP Impurity G) is an impurity of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel (P132500). Docetaxel is an antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin.

General Description

Docetaxel is available in single-dose vials of 20 mg/0.5 mLand 80 mg/2 mL for IV administration in the treatment of breast, NSCLC, and prostate cancers. It has also been utilizedin non–FDA-approved treatment of head, neck, gastric,bladder, and refractory ovarian cancers.
Docetaxel is highly plasma protein bound (80%) andwidely distributed with the highest concentration in the hepatobiliarysystem, but it does not appear to cross the bloodbrainbarrier. The metabolism of docetaxel has been lesswell studied than that of paclitaxel. The use of human livermicrosomes has indicated that metabolism involves oxidationof one of the tert-butyl methyl groups of the C-13 sidechain to initially give the alcohol. Further oxidation to thealdehyde and carboxylic acid both of which may cyclizewith the carbamate nitrogen to give stereoisomeric hydroxyoxazolidinonesand an oxazolidinedione, respectively. Noactive metabolites have been identified. The major enzymeinvolved is CYP3A4. The drug is primarily eliminated in thefeces with a terminal half-life of 11 hours.
The adverse effects profile for docetaxel is similar to thatof paclitaxel but also includes reversible fluid retention that isdose related. This has been associated with an initial increasein capillary permeability followed by a decrease in lymphaticdrainage later in the therapy. Restriction of sodium intake andpretreatment with corticosteroids is usually successful inminimizing this adverse effect. Peripheral neuropathy is seenwith docetaxel but occurs less often than with paclitaxel.Fatigue and muscle pain are commonly seen, and fever mayoccur in up to 30% of patients who are infection free.

Docetaxel Preparation Products And Raw materials

Raw materials

Preparation Products

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Docetaxel Suppliers

Canada 3 China 173 India 7 Israel 1 Italy 2 South Korea 1 United Kingdom 2 United States 15 Global 204
PHYTON BIOTECH LLC
Tel
--
Fax
--
Email
inquiries@phytonbiotech.com
Country
Canada
ProdList
5
Advantage
58
BIOVECTRA INC
Tel
--
Fax
--
Country
Canada
ProdList
3
Advantage
58
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
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View Lastest Price from Docetaxel manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Docetaxel 125354-16-7
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-10-22
Dideu Industries Group Limited
Product
Docetaxel 125354-16-7
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-02
Shaanxi Dideu Medichem Co. Ltd
Product
Docetaxel 125354-16-7
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
800 ton
Release date
2020-04-30

125354-16-7, DocetaxelRelated Search:

Docetaxel Paclitaxel tert-Butanol tert-Butyl peroxyacetate tert-Butyl acetate DOCETAXEL HYDRATE,Docetaxel trihydrate (2R,3S)-2-HYDROXY-3-(N-TERTBUTOXYCARBONYL) AMINO-3- PHENYL- METHYL PROPIONATE (INTERMEDIATE OF DOCETAXEL) SIDE CHAINS OF DOCETAXEL--4 SIDE CHAINS OF DOCETAXEL--1 SIDE CHAINS OF DOCETAXEL--3 10-Oxo Docetaxel 13-O-(Triethylsilyl) Baccatin III 2-Debenzoyl-2-pentenoyl Docetaxel Docetaxel Impurity 5 Docetaxel impurity 1/(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-6,9,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(((2,2,2-trichloroethoxy)carbonyl)oxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl Docetaxel Impurity 36 (2S,3S)-methyl 3-(tert-butoxycarbonylamino)-2-hydroxy-3-phenylpropanoate Docetaxel Impurity 15

  • 10-Acetyldocetaxel
  • 10-Acetyltaxotere
  • Docetaxal
  • PNU 101383
  • ACETYLDOCETAXEL, 10-(P)
  • Docetaxel N-Debenzoyl-N-(tert-butoxycarbonyl)taxol
  • Docetaxel impurity G
  • Docetaxel Impurity 7(Docetaxel EP Impurity G)
  • DOCETAXOL
  • N-Debenzoyl-N-(tert-butoxycarbonyl)taxol
  • Docetaxel EP Impurity G
  • CS-878
  • Paclitaxel Impurity 3
  • Docetaxel EP Impurity G (10-Acetyl Docetaxel)
  • Docetaxel impurity 7/Docetaxel EP Impurity G/10-Acetyl Docetaxel/(αR,βS)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxybenzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dode
  • Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,...
  • (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12-(benzoyloxy)-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b-diyldiacetate
  • Docetaxel,125354-16-7
  • MK-0431 phosphate
  • 5β,20-epoxy-1,7β-dihydroxy-9-oxotax-11-ene-2α,4,10β,13α-tetrayl 4,10-diacetate 2-benzoate 13-[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-3-phenylpropanoate] (10-acetyldocetaxel).
  • Docetaxel EP Impurity G（Paclitaxel Impurity 3）
  • ACETYLDOCETAXEL, 10-
  • (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12-(benzoyloxy)-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12
  • 125354-16-7
  • C45H55NO15