Docetaxel

ChemicalBook > CAS DataBase List > Docetaxel

Product Name: Docetaxel
CAS No.: 125354-16-7
Chemical Name: Docetaxel
Synonyms: CS-878;DOCETAXOL;Docetaxal;PNU 101383;10-Acetyltaxotere;MK-0431 phosphate;10-Acetyldocetaxel;Docetaxel impurity G;ACETYLDOCETAXEL, 10-;Paclitaxel Impurity 3
CBNumber: CB7842087
Molecular Formula: C45H55NO15
Formula Weight: 849.93
MOL File: 125354-16-7.mol

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Docetaxel Property

Melting point:: 201-203 °C(Solv: methanol (67-56-1))
Boiling point:: 901.4±65.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 11.20±0.46(Predicted)
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: D494565
Product name: Docetaxal
Packaging: 100mg
Price: $120
Updated: 2021/12/16

TRC

Product number: D494565
Product name: Docetaxal
Packaging: 1g
Price: $580
Updated: 2021/12/16

Usbiological

Product number: 163942
Product name: Docetaxal
Packaging: 5mg
Price: $460
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0010442
Product name: 10-ACETYLDOCETAXEL
Purity: 95.00%
Packaging: 10MG
Price: $477.75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA46386
Product name: 10-Acetyl docetaxel
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

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Docetaxel Chemical Properties,Usage,Production

Uses

Docetaxal is an impurity of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel (P132500). Docetaxel is an antimitotic agent that promotes the assembly of micro-tubules and inhibits their de -polymerization to free tubulin.

Uses

Docetaxal (Docetaxel EP Impurity G) is an impurity of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel (P132500). Docetaxel is an antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin.

General Description

Docetaxel is available in single-dose vials of 20 mg/0.5 mLand 80 mg/2 mL for IV administration in the treatment of breast, NSCLC, and prostate cancers. It has also been utilizedin non–FDA-approved treatment of head, neck, gastric,bladder, and refractory ovarian cancers.
Docetaxel is highly plasma protein bound (80%) andwidely distributed with the highest concentration in the hepatobiliarysystem, but it does not appear to cross the bloodbrainbarrier. The metabolism of docetaxel has been lesswell studied than that of paclitaxel. The use of human livermicrosomes has indicated that metabolism involves oxidationof one of the tert-butyl methyl groups of the C-13 sidechain to initially give the alcohol. Further oxidation to thealdehyde and carboxylic acid both of which may cyclizewith the carbamate nitrogen to give stereoisomeric hydroxyoxazolidinonesand an oxazolidinedione, respectively. Noactive metabolites have been identified. The major enzymeinvolved is CYP3A4. The drug is primarily eliminated in thefeces with a terminal half-life of 11 hours.
The adverse effects profile for docetaxel is similar to thatof paclitaxel but also includes reversible fluid retention that isdose related. This has been associated with an initial increasein capillary permeability followed by a decrease in lymphaticdrainage later in the therapy. Restriction of sodium intake andpretreatment with corticosteroids is usually successful inminimizing this adverse effect. Peripheral neuropathy is seenwith docetaxel but occurs less often than with paclitaxel.Fatigue and muscle pain are commonly seen, and fever mayoccur in up to 30% of patients who are infection free.

Docetaxel Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Docetaxel manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Product: Docetaxel 125354-16-7
Price: US $0.00/KG
Min. Order: 100g
Purity: 98%+
Supply Ability: 100kg
Release date: 2020-10-22

Dideu Industries Group Limited

Product: Docetaxel 125354-16-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-02

Shaanxi Dideu Medichem Co. Ltd

Product: Docetaxel 125354-16-7
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 800 ton
Release date: 2020-04-30

125354-16-7, DocetaxelRelated Search:

Docetaxel Paclitaxel tert-Butanol tert-Butyl peroxyacetate tert-Butyl acetate DOCETAXEL HYDRATE,Docetaxel trihydrate (2R,3S)-2-HYDROXY-3-(N-TERTBUTOXYCARBONYL) AMINO-3- PHENYL- METHYL PROPIONATE (INTERMEDIATE OF DOCETAXEL) SIDE CHAINS OF DOCETAXEL--4 SIDE CHAINS OF DOCETAXEL--1 SIDE CHAINS OF DOCETAXEL--3 10-Oxo Docetaxel 13-O-(Triethylsilyl) Baccatin III 2-Debenzoyl-2-pentenoyl Docetaxel Docetaxel Impurity 5 Docetaxel impurity 1/(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-6,9,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(((2,2,2-trichloroethoxy)carbonyl)oxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl Docetaxel Impurity 36 (2S,3S)-methyl 3-(tert-butoxycarbonylamino)-2-hydroxy-3-phenylpropanoate Docetaxel Impurity 15

10-Acetyldocetaxel

10-Acetyltaxotere

Docetaxal

PNU 101383

ACETYLDOCETAXEL, 10-(P)

Docetaxel N-Debenzoyl-N-(tert-butoxycarbonyl)taxol

Docetaxel impurity G

Docetaxel Impurity 7(Docetaxel EP Impurity G)

DOCETAXOL

N-Debenzoyl-N-(tert-butoxycarbonyl)taxol

Docetaxel EP Impurity G

CS-878

Paclitaxel Impurity 3

Docetaxel EP Impurity G (10-Acetyl Docetaxel)

Docetaxel impurity 7/Docetaxel EP Impurity G/10-Acetyl Docetaxel/(αR,βS)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxybenzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dode

Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,...

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12-(benzoyloxy)-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b-diyldiacetate

Docetaxel,125354-16-7

MK-0431 phosphate

5β,20-epoxy-1,7β-dihydroxy-9-oxotax-11-ene-2α,4,10β,13α-tetrayl 4,10-diacetate 2-benzoate 13-[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-3-phenylpropanoate] (10-acetyldocetaxel).

Docetaxel EP Impurity G（Paclitaxel Impurity 3）

ACETYLDOCETAXEL, 10-

125354-16-7

C45H55NO15