1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE

Product Name: 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE
CAS No.: 105628-72-6
Chemical Name: 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE
Synonyms: Ha 1100;Fasudil Impurity L;Fasudil Impurity 5;1-[(1,2-DIHYDRO-1-OX;HA 1100 HYDROCHLORIDE;HA-1100;HA 1100;HA1100;HYDROXYFASUDIL;HA-1100;HA 1100;HA1100;5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1-ol;5-((1,4-Diazepan-1-yl)sulfonyl)isoquinolin-1(2H)-one;5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1(8aH)-one
CBNumber: CB7847446
Molecular Formula: C14H17N3O3S
Formula Weight: 307.37
MOL File: 105628-72-6.mol

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1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Property

storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Soluble in DMSO
form: Solid
color: White to off-white

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Safety

Toxicity: mouse,LD50,unreported,145mg/kg (145mg/kg),United States Patent Document. Vol. #4678783,

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 2415
Product name: HA1100hydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $244
Updated: 2021/12/16

Usbiological

Product number: 255432
Product name: HA 1100 hydrochloride
Packaging: 10mg
Price: $516
Updated: 2021/12/16

AK Scientific

Product number: 3044AH
Product name: 1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine
Packaging: 5mg
Price: $258
Updated: 2021/12/16

ApexBio Technology

Product number: A3478
Product name: Hydroxyfasudil
Packaging: 10mg
Price: $126
Updated: 2021/12/16

ChemScene

Product number: CS-1599
Product name: Hydroxyfasudil
Purity: 98.11%
Packaging: 10mg
Price: $136
Updated: 2021/12/16

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1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Chemical Properties,Usage,Production

Biological Activity

Cell-permeable active metabolite of Fasudil (HA 1077; Fasudil hydrochloride). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo .

1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE Suppliers

China 63 Germany 1 South Korea 1 Switzerland 1 United Kingdom 1 United States 16 Global 83

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View Lastest Price from 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE manufacturers

Career Henan Chemical Co

Product: 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE 105628-72-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1lg; 2kg; 5kg; 10kg; 100kg
Release date: 2019-08-31

105628-72-6, 1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINERelated Search:

5-Quinolinesulfonic acid, 2-methyl- Fasudil Impurity 6 Fasudil Impurity 13 Fasudil Pyridine N-Oxide TFA Salt Fasudil Impurity 9 Fasudil Impurity 34 Fasudil iMpurity Fasudil Impurity 7 1-[(1-Chloro-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine Fasudil Impurity 8 1-Chloro-5-isoquinolinesulfonic Acid Fasudil Impurity 6 1,4-ditosyl-1,4-diazepane Fasudil diMer Fasudil N-hydroxy iMpurity N-(3-HYDROXYPROPYL)ETHYLENEDIAMINE Isoquinoline HYDROXYFASUDIL MONOHYDROCHLORIDE

5-(1,4-diazepane-1-sulfonyl)-1,2-dihydroisoquinolin-1-one

HYDROXYFASUDIL;HA-1100;HA 1100;HA1100

1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE

1H-1,4-Diazepine, hexahydro-1-((1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl)-

Ha 1100

Hexahydro-1-((1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl)-1H-1,4-diazepine

1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepinehydrochloride

5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1-ol

Fasudil Impurity L

HA 1100 HYDROCHLORIDE

1-[(1,2-DIHYDRO-1-OX

5-((1,4-Diazepan-1-yl)sulfonyl)isoquinolin-1(2H)-one

Fasudil impurity 12/5-(1,4-diazepan-1-ylsulfonyl)-2H-isoquinolin-1-one hydrochloride

HA-1100;HA 1100;HA1100

1(2H)-Isoquinolinone, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-

5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1(8aH)-one

HA1100,ROCK,Rho-kinase,inhibit,Rho-associated kinase,Inhibitor,ROK,Hydroxyfasudil,HA 1100,Rho-associated protein kinase

Fasudil Impurity 5

105628-72-6

C14H17N3O3S

Angiogenesis and Metastasis

Intracellular signaling