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Glutaric acid

Product Name
Glutaric acid
CAS No.
110-94-1
Chemical Name
Glutaric acid
Synonyms
PENTANEDIOIC ACID;glutaric;1,5-PENTANEDIOIC ACID;1,5-PENTADIOIC ACID;1,3-PROPANEDICARBOXYLIC ACID;Glutarsure;Glutarsaure;utaric acid;lutaric acid;G1utaric Acid
CBNumber
CB7852828
Molecular Formula
C5H8O4
Formula Weight
132.11
MOL File
110-94-1.mol
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Glutaric acid Property

Melting point:
95-98 °C (lit.)
Boiling point:
200 °C/20 mmHg (lit.)
Density 
1,429 g/cm3
vapor pressure 
0.022 hPa (18.5 °C)
refractive index 
nD106 1.41878
Flash point:
200°C/20mm
storage temp. 
Store below +30°C.
solubility 
water: soluble5mg/mL, clear to slightly hazy, colorless to faintly yellow
pka
4.31(at 25℃)
form 
Crystalline Powder
color 
Orange
PH
3.7(1 mM solution);3.17(10 mM solution);2.66(100 mM solution)
Water Solubility 
430 g/L (20 ºC)
Merck 
14,4473
BRN 
1209725
Stability:
Stable. Incompatible with bases, oxidizing agents, reducing agents.
InChIKey
JFCQEDHGNNZCLN-UHFFFAOYSA-N
LogP
-0.26 at 25℃
CAS DataBase Reference
110-94-1(CAS DataBase Reference)
NIST Chemistry Reference
Pentanedioic acid(110-94-1)
EPA Substance Registry System
Pentanedioic acid (110-94-1)
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Safety

Hazard Codes 
Xi
Risk Statements 
36-36/37/38
Safety Statements 
26-37/39-36-39
WGK Germany 
1
RTECS 
MA3740000
TSCA 
Yes
HS Code 
29171990
Hazardous Substances Data
110-94-1(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G3407
Product name
Glutaric acid
Purity
99%
Packaging
25g
Price
$26.7
Updated
2024/03/01
Sigma-Aldrich
Product number
8.00295
Product name
Glutaric acid
Purity
for synthesis
Packaging
100g
Price
$78.5
Updated
2024/03/01
Sigma-Aldrich
Product number
89147
Product name
Glutaric acid
Purity
certified reference material, TraceCERT
Packaging
100mg
Price
$133
Updated
2024/03/01
Sigma-Aldrich
Product number
8.00295
Product name
Glutaric acid
Purity
for synthesis
Packaging
250g
Price
$159
Updated
2024/03/01
Sigma-Aldrich
Product number
8.00295
Product name
Glutaric acid
Purity
for synthesis
Packaging
1kg
Price
$455
Updated
2024/03/01
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Glutaric acid Chemical Properties,Usage,Production

Description

Glutaric acid is a dicarboxylic acid with carboxylic acid functional groups at either either end of the molecular chain. The terminal carboxylic acid groups can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Chemical Properties

white or off-white crystals, usually containing 1mol crystal water. Soluble in water, alcohol, ether and chloroform, slightly soluble in petroleum ether.

Occurrence

Glutaric acid occurs in washings from fleece and, together with malonic acid, in the juice of unripened sugar beet.

Uses

Glutaric acid is used as the raw material for organic synthesis, pharmaceutical intermediate and synthetic resin. It serves as a precursor in the production of polyester polyols, polyamides, ester plasticizers and corrosion inhibitors. It is useful to decrease polymer elasticity and in the synthesis surfactants and metal finishing compounds. It acts as an intermediate during the catabolism of lysine in mammals.

Definition

ChEBI: glutaric acid is an alpha,omega-dicarboxylic acid that is a linear five-carbon dicarboxylic acid. It has a role as a human metabolite and a Daphnia magna metabolite. It is an alpha,omega-dicarboxylic acid and a dicarboxylic fatty acid. It is a conjugate acid of a glutarate(1-) and a glutarate.

Preparation

glutaric acid is produced as a by-product of the production process of adipic acid (about 2% of the output of an adipic acid plant is glutaric); Glutaric acid can be produced through various chemical routes, for example, from cyclopentane by oxidation with molecular oxygen and cobalt (III) catalysts or by ozonolysis; and from cyclopentanol–cyclopentanone by oxidation with oxygen and Co(CH3CO2)2, with potassium peroxide in benzene, or with N2O4 or nitric acid. Together with succinic acid, glutaric acid is formed as a by-product during oxidation of cyclohexanol–cyclohexanone in the adipic acid production process.

Application

The applications of glutaric acid, e.g., as an intermediate, are limited. Its use as a starting material in the manufacture of maleic acid has no commercial importance. it does not usually reach the market because it is converted into dibasic esters and sold as environmentally friendly solvents.

Synthesis Reference(s)

Journal of the American Chemical Society, 78, p. 2489, 1956 DOI: 10.1021/ja01592a042
Organic Syntheses, Coll. Vol. 1, p. 290, 1941
Synthetic Communications, 10, p. 205, 1980 DOI: 10.1080/00397918008064223

General Description

Glutaric acid appears as colorless crystals or white solid. (NTP, 1992)

Air & Water Reactions

Water soluble.

Reactivity Profile

1,5-Pentanedioic acid is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in 1,5-Pentanedioic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions 1,5-Pentanedioic acid reacts with bases, oxidizing agents and reducing agents.

Fire Hazard

Flash point data for 1,5-Pentanedioic acid are not available; however, 1,5-Pentanedioic acid is probably combustible.

Flammability and Explosibility

Not classified

Purification Methods

Crystallise the acid from *benzene, CHCl3, distilled water or *benzene containing 10% (w/w) of diethyl ether. Dry it under vacuum. [Beilstein 2 IV 1934.]

Glutaric acid Preparation Products And Raw materials

Raw materials

Adipic acid oxidized paraffin(wax) Paraffin wax Dihydropyran 2,3-Dihydrofuran Nitrogen Tetroxide 1,3-Propanediol Glutaronitrile Ammonium chloride Nitric acid Cyclohexanone Cyclopentanone POTASSIUM CYANIDE Gamma Butyrolactone

Preparation Products

Buspirone Cinmethylin Azelaic acid Glutaric anhydride Baclofen LACCAIC ACID
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View Lastest Price from Glutaric acid manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Glutaric Acid 110-94-1
Price
US $99.00-35.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-13
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Pentanedioic Acid 110-94-1
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-12-13
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Glutaric acid 110-94-1
Price
US $999.00-800.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-22

110-94-1, Glutaric acidRelated Search:

Diethyl glutarate MONO-METHYL GLUTARATE Dimethyl Glutarate ETHYL HYDROGEN GLUTARATE Glutaric anhydride ethyl pentanimidate hydrochloride Glutarimide Glutacondianil hydrochloride 3-(cyanomethylene)glutaric acid dimethyl ester GLUTARIC ACID-2-METHYLAMINO-5-NITROMONOANILIDE PHOSPHORUS PENTABROMIDE Glutaraldehyde Phosphorus pentoxide Isocitric acid trisodium salt N-Cbz-L-glutamic acid D-(+)-Camphoric acid 2-Ketoglutaric acid Glutaric acid

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