Propionic anhydride

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Propionic anhydride

Product Name: Propionic anhydride
CAS No.: 123-62-6
Chemical Name: Propionic anhydride
Synonyms: propionic;Propionic acid anhydride;PROPANOIC ANHYDRIDE;propionyloxide;Propionyl oxide;C2H5C(O)OC(O)C2H5;Propinoicanhydride;Propanic Anhydride;PROPIONIC ANHYDRIDE;Propionic Anhydried
CBNumber: CB7852974
Molecular Formula: C6H10O3
Formula Weight: 130.14
MOL File: 123-62-6.mol

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Propionic anhydride Property

Melting point:: -42 °C
Boiling point:: 167 °C(lit.)
Density: 1.015 g/mL at 25 °C(lit.)
vapor density: 4.5 (vs air)
vapor pressure: 10 mm Hg ( 57.7 °C)
refractive index: n20/D 1.404(lit.)
Flash point:: 165 °F
storage temp.: Store below +30°C.
solubility: H2O: decomposes (when in contact with water)
form: clear liquid
color: Colorless to Almost colorless
Odor: like acetaldehyde
PH: 2.5 (100g/l, H2O, 20℃)(calculated on the free acid)
explosive limit: 1.3-9.5%(V)
Water Solubility: hydrolyses
Sensitive: Moisture Sensitive
Merck: 14,7826
BRN: 507066
Dielectric constant: 18.300000000000001
Dielectric constant: 18.0（16℃）
Stability:: Stable. Combustible. Incompatible with strong oxidizing agents, water, moisture, most common metals, active halogen compounds, ammonia, amines.
LogP: 0.33 at 20℃
CAS DataBase Reference: 123-62-6(CAS DataBase Reference)
NIST Chemistry Reference: Propanoic acid, anhydride(123-62-6)
EPA Substance Registry System: Propionic anhydride (123-62-6)

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Safety

Hazard Codes: C
Risk Statements: 34-R34
Safety Statements: 26-45-S45-S26
RIDADR: UN 2496 8/PG 3
WGK Germany: 1
RTECS: UF9100000
Autoignition Temperature: 545 °F
Hazard Note: Corrosive/Moisture Sensitive
TSCA: Yes
HS Code: 2915 90 70
HazardClass: 8
PackingGroup: III
Hazardous Substances Data: 123-62-6(Hazardous Substances Data)
Toxicity: LD50 orally in rats: 2.36 g/kg (Smyth)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.00608
Product name: Propionic anhydride
Purity: for synthesis
Packaging: 100mL
Price: $27
Updated: 2024/03/01

Sigma-Aldrich

Product number: 81942
Product name: Propionic anhydride
Purity: purum, ≥96.0% (NT)
Packaging: 1l
Price: $81.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.00608
Product name: Propionic anhydride
Purity: for synthesis
Packaging: 500mL
Price: $47.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.00608
Product name: Propionic anhydride
Purity: for synthesis
Packaging: 1L
Price: $78.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 240311
Product name: Propionic anhydride
Purity: ≥99%
Packaging: 50g
Price: $59.5
Updated: 2024/03/01

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Propionic anhydride Chemical Properties,Usage,Production

Chemical Properties

Propionic anhydride is a colorless liquid. Strong, pungent, unpleasant odor. Soluble in methanol, ethanol, ether, chloroform and alkali, decomposes in water.

Uses

Propionic anhydride is used as a esterifying agent for certain perfume oils, fats, oils, and especially cellulose and as a reagent in organic synthesis. In the production of alkyd resins, dyestuffs and drugs. Has been used as a dehydrating agent in some sulfonations and nitrations.

Application

Propionic anhydride was previously used in the preparation of α and β-1-propionyl derivatives of glucopyranose tetra-acetate.

General Description

Propionic anhydride is an organic compound with the molecular formula (CH3CH2CO)2O. it is an colorless acid anhydride that is widely used as a reagent in organic synthesis.

Air & Water Reactions

Decomposes exothermically in water to form a corrosive solution of propionic acid [Merck, 11th ed. 1989].

Reactivity Profile

Propionic anhydride reacts exothermically with water. The reactions are sometimes slow, but can become violent when local heating accelerates their rate. Acids accelerate the reaction with water. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases.

Hazard

Strong irritant to tissue.

Health Hazard

Inhalation causes irritation of eyes and respiratory tract. Contact with liquid causes burns of eyes and skin. Ingestion causes burns of mouth and stomach.

Fire Hazard

Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Flammability and Explosibility

Non flammable

Safety Profile

Moderately toxic by ingestion. Mildly toxic by skin contact. A corrosive irritant to skin, eyes, and mucous membranes. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. Used as an esterifyng agent and dehydrating agent. See also ANHYDRIDES.

Safety

Propanoic anhydride is strong smelling and corrosive, and will cause burns on contact with skin. Vapour can burn eyes and lungs.

Synthesis

Propanoic anhydride has been prepared by dehydration of propanoic acid using ketene :
2 CH₃CH₂CO₂H + CH₂= C= O → (CH₃CH₂CO)₂O + CH₃CO₂H.

Potential Exposure

Used in the manufacture of perfumes, flavorings, alkyd resins; dyestuffs, pharmaceuticals; as an esterifying agent for fats, oils, and cellulose; dehydrating medium for nitrations and sulfonations.

Shipping

UN2496 Propionic anhydride, Hazard class: 8; Labels: 8-Corrosive material.

Purification Methods

Shake the anhydride with P2O5 for several minutes, then distil. [Beilstein 2 IV 722.]

Incompatibilities

Vapors may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, perox- ides, permanganates, perchlorates, chlorine, bromine, fluo- rine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, reducing agents; alcohols and metals. Contact with water forms heat 1 flammable propionic acid. Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercap- tans, nitrides, and sulfides (releasing heat, toxic and possibly flammable gases), thiosulfates and dithionites (releasing hydrogen sulfate and oxides of sulfur).

Waste Disposal

Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

Propionic anhydride Preparation Products And Raw materials

Raw materials

Propionyl chloride Sodium propionate

Preparation Products

LINALYL PROPIONATE cis-Anethol (-)-CARVYL PROPIONATE Erythromycin Estolate PROPIONYLTHIOCHOLINE IODIDE Tralkoxydim Alclometasone Dipropionate 3-METHYL-CHROMEN-2-ONE CITRONELLYL PROPIONATE 2-ETHYL-3-HYDROXY-6-METHYLPYRIDINE 3-Methylquinoline Deprodone propionate (5-Fluoro-2-methyl-1H-inden-3-yl)acetic acid Hydrocortisone Butyrate Propionate 6-Methoxy-2-Acetyl Naphthalene 6-Methylcoumarin Disperse Blue SE-2R 2-PROPIONYLFURAN

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View Lastest Price from Propionic anhydride manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: Propionic anhydride 123-62-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-10-25

Hebei Chuanghai Biotechnology Co,.LTD

Product: Propionic anhydride 123-62-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99.%
Supply Ability: 10 ton
Release date: 2024-08-05

Hebei Mujin Biotechnology Co.,Ltd

Product: Propionic anhydride 123-62-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-14

123-62-6, Propionic anhydrideRelated Search:

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propanoic acid 1-oxopropyl ester

PROPANOIC ANHYDRIDE

PROPIONIC ANHYDRIDE

Propinoicanhydride

propionic

Propionic acid anhydride

propionicacidanhydride

Propionyl oxide

propionyloxide

Propionic Anhydried

Anhydrid kyseliny propionove

anhydridkyselinypropionove

C2H5C(O)OC(O)C2H5

Methylacetic anhydride

methylaceticanhydride

Propanoicacid,anhydride

Propanic Anhydride

PROPIONIC ANHYDRIDE, 99+%

PropionicAnhydrideForSynthesis

Propionic anhydride 97%

PROPIONSAEUREANHYDRID

Propionsureanhydrid

PROPIONIC Anhydride extrapure

Propionic anhydride Methylacetic anhydride

Bispropanoic anhydride

Bispropionic acid anhydride

Dipropionic anhydride

Propionic anhydride, synthesis grade

Propanoic anhydride 97%

Propionic anhydride, Propanoyl propanoate

Propionic anhydride, 99% 1LT

Propanoic acid,1,1'-anhydride

Propionic anhydride puruM, >=96.0% (NT)

PropionicAnhydride&gt

Propionic anhydride, puriss, 97%+

Propionic anhydride, puriss

Propionic anhydride,97%

Propionic Anhydride, ≥ 98.0%

Carprofen Impurity 14

123-62-6

123-62-2

CH3CH2CO2O

Carbonyl Compounds

Carboxylic Acid Anhydrides

Building Blocks

Organic Building Blocks

Biochemicals and Reagents

Carboxylic Acid Anhydrides

Fatty Acids and conjugates

Fatty Acyls

Saturated Fatty Acids and Derivatives

Anhydrides

Building Blocks

Carbonyl Compounds

Chemical Synthesis

Lipids

Organic Building Blocks

Acylation Reagent