ChemicalBook > CAS DataBase List > Propionic anhydride

Propionic anhydride

Product Name
Propionic anhydride
CAS No.
123-62-6
Chemical Name
Propionic anhydride
Synonyms
propionic;Propionic acid anhydride;PROPANOIC ANHYDRIDE;propionyloxide;Propionyl oxide;C2H5C(O)OC(O)C2H5;Propinoicanhydride;Propanic Anhydride;PROPIONIC ANHYDRIDE;Propionic Anhydried
CBNumber
CB7852974
Molecular Formula
C6H10O3
Formula Weight
130.14
MOL File
123-62-6.mol
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Propionic anhydride Property

Melting point:
-42 °C
Boiling point:
167 °C(lit.)
Density 
1.015 g/mL at 25 °C(lit.)
vapor density 
4.5 (vs air)
vapor pressure 
10 mm Hg ( 57.7 °C)
refractive index 
n20/D 1.404(lit.)
Flash point:
165 °F
storage temp. 
Store below +30°C.
solubility 
H2O: decomposes (when in contact with water)
form 
clear liquid
color 
Colorless to Almost colorless
Odor
like acetaldehyde
PH
2.5 (100g/l, H2O, 20℃)(calculated on the free acid)
explosive limit
1.3-9.5%(V)
Water Solubility 
hydrolyses
Sensitive 
Moisture Sensitive
Merck 
14,7826
BRN 
507066
Dielectric constant
18.300000000000001
Dielectric constant
18.0（16℃）
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, water, moisture, most common metals, active halogen compounds, ammonia, amines.
LogP
0.33 at 20℃
CAS DataBase Reference
123-62-6(CAS DataBase Reference)
NIST Chemistry Reference
Propanoic acid, anhydride(123-62-6)
EPA Substance Registry System
Propionic anhydride (123-62-6)
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Safety

Hazard Codes 
C
Risk Statements 
34-R34
Safety Statements 
26-45-S45-S26
RIDADR 
UN 2496 8/PG 3
WGK Germany 
1
RTECS 
UF9100000
Autoignition Temperature
545 °F
Hazard Note 
Corrosive/Moisture Sensitive
TSCA 
Yes
HS Code 
2915 90 70
HazardClass 
8
PackingGroup 
III
Hazardous Substances Data
123-62-6(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 2.36 g/kg (Smyth)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.00608
Product name
Propionic anhydride
Purity
for synthesis
Packaging
100mL
Price
$27
Updated
2024/03/01
Sigma-Aldrich
Product number
81942
Product name
Propionic anhydride
Purity
purum, ≥96.0% (NT)
Packaging
1l
Price
$81.7
Updated
2024/03/01
Sigma-Aldrich
Product number
8.00608
Product name
Propionic anhydride
Purity
for synthesis
Packaging
500mL
Price
$47.8
Updated
2024/03/01
Sigma-Aldrich
Product number
8.00608
Product name
Propionic anhydride
Purity
for synthesis
Packaging
1L
Price
$78.2
Updated
2024/03/01
Sigma-Aldrich
Product number
240311
Product name
Propionic anhydride
Purity
≥99%
Packaging
50g
Price
$59.5
Updated
2024/03/01
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Propionic anhydride Chemical Properties,Usage,Production

Chemical Properties

Propionic anhydride is a colorless liquid. Strong, pungent, unpleasant odor. Soluble in methanol, ethanol, ether, chloroform and alkali, decomposes in water.

Uses

Propionic anhydride is used as a esterifying agent for certain perfume oils, fats, oils, and especially cellulose and as a reagent in organic synthesis. In the production of alkyd resins, dyestuffs and drugs. Has been used as a dehydrating agent in some sulfonations and nitrations.

Application

Propionic anhydride was previously used in the preparation of α and β-1-propionyl derivatives of glucopyranose tetra-acetate.

General Description

Propionic anhydride is an organic compound with the molecular formula (CH3CH2CO)2O. it is an colorless acid anhydride that is widely used as a reagent in organic synthesis.

Air & Water Reactions

Decomposes exothermically in water to form a corrosive solution of propionic acid [Merck, 11th ed. 1989].

Reactivity Profile

Propionic anhydride reacts exothermically with water. The reactions are sometimes slow, but can become violent when local heating accelerates their rate. Acids accelerate the reaction with water. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases.

Hazard

Strong irritant to tissue.

Health Hazard

Inhalation causes irritation of eyes and respiratory tract. Contact with liquid causes burns of eyes and skin. Ingestion causes burns of mouth and stomach.

Fire Hazard

Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Flammability and Explosibility

Non flammable

Safety Profile

Moderately toxic by ingestion. Mildly toxic by skin contact. A corrosive irritant to skin, eyes, and mucous membranes. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. Used as an esterifyng agent and dehydrating agent. See also ANHYDRIDES.

Safety

Propanoic anhydride is strong smelling and corrosive, and will cause burns on contact with skin. Vapour can burn eyes and lungs.

Synthesis

Propanoic anhydride has been prepared by dehydration of propanoic acid using ketene :
2 CH3CH2CO2H + CH2= C= O → (CH3CH2CO)2O + CH3CO2H.

Potential Exposure

Used in the manufacture of perfumes, flavorings, alkyd resins; dyestuffs, pharmaceuticals; as an esterifying agent for fats, oils, and cellulose; dehydrating medium for nitrations and sulfonations.

Shipping

UN2496 Propionic anhydride, Hazard class: 8; Labels: 8-Corrosive material.

Purification Methods

Shake the anhydride with P2O5 for several minutes, then distil. [Beilstein 2 IV 722.]

Incompatibilities

Vapors may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, perox- ides, permanganates, perchlorates, chlorine, bromine, fluo- rine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, reducing agents; alcohols and metals. Contact with water forms heat 1 flammable propionic acid. Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercap- tans, nitrides, and sulfides (releasing heat, toxic and possibly flammable gases), thiosulfates and dithionites (releasing hydrogen sulfate and oxides of sulfur).

Waste Disposal

Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

Propionic anhydride Preparation Products And Raw materials

Raw materials

Propionyl chloride Sodium propionate

Preparation Products

LINALYL PROPIONATE cis-Anethol (-)-CARVYL PROPIONATE Erythromycin Estolate PROPIONYLTHIOCHOLINE IODIDE Tralkoxydim Alclometasone Dipropionate 3-METHYL-CHROMEN-2-ONE CITRONELLYL PROPIONATE 2-ETHYL-3-HYDROXY-6-METHYLPYRIDINE 3-Methylquinoline Deprodone propionate (5-Fluoro-2-methyl-1H-inden-3-yl)acetic acid Hydrocortisone Butyrate Propionate 6'-Methoxy-2'-propiononaphthone 6-Methylcoumarin Disperse Blue SE-2R 2-PROPIONYLFURAN
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View Lastest Price from Propionic anhydride manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
Propionic anhydride 123-62-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-14
Weijer International Trade (Hebei) Co., Ltd
Product
Propionic anhydride 123-62-6
Price
US $80.00/KG
Min. Order
1KG
Purity
>99%
Supply Ability
20tons
Release date
2023-03-22
Hebei Mingeng Biotechnology Co., Ltd
Product
Propionic anhydride 123-62-6
Price
US $150.00/ASSAYS
Min. Order
10g
Purity
>99%
Supply Ability
500kg/month
Release date
2021-11-22

123-62-6, Propionic anhydrideRelated Search:

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  • Anhydrid kyseliny propionove
  • anhydridkyselinypropionove
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  • 123-62-6
  • 123-62-2
  • CH3CH2CO2O
  • Carbonyl Compounds
  • Carboxylic Acid Anhydrides
  • Building Blocks
  • Organic Building Blocks
  • Biochemicals and Reagents
  • Carboxylic Acid Anhydrides
  • Fatty Acids and conjugates
  • Fatty Acyls
  • Saturated Fatty Acids and Derivatives
  • Anhydrides
  • Building Blocks
  • Carbonyl Compounds
  • Chemical Synthesis
  • Lipids
  • Organic Building Blocks
  • Acylation Reagent