Trimethylacetic anhydride

Product Name: Trimethylacetic anhydride
CAS No.: 1538-75-6
Chemical Name: Trimethylacetic anhydride
Synonyms: PIVALIC ANHYDRIDE;Bis(2,2-dimethylpropionic)anhydride;Pivalic anydride;Bis(pivalic)anhydride;Pivalic acid anhydride;2,2-Dimethylpropanoicanhydride;2,2-dimethylpropanoyl 2,2-dimethylpropanoate;Pivolic Anhydride;Dipivalic anhydride;PivalicAnhydride>
CBNumber: CB9470666
Molecular Formula: C10H18O3
Formula Weight: 186.25
MOL File: 1538-75-6.mol

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Trimethylacetic anhydride Property

Boiling point:: 193 °C(lit.)
Density: 0.918 g/mL at 25 °C(lit.)
vapor pressure: 62.1Pa at 25℃
refractive index: n20/D 1.409(lit.)
Flash point:: 135 °F
storage temp.: Inert atmosphere,Room Temperature
solubility: Miscible with acetonitrile.
form: Liquid
color: Clear colorless
Sensitive: Moisture Sensitive
BRN: 386552
InChI: InChI=1S/C10H18O3/c1-9(2,3)7(11)13-8(12)10(4,5)6/h1-6H3
InChIKey: PGZVFRAEAAXREB-UHFFFAOYSA-N
SMILES: C(C)(C)(C)C(=O)OC(=O)C(C)(C)C
LogP: 2.15
CAS DataBase Reference: 1538-75-6(CAS DataBase Reference)
EPA Substance Registry System: Propanoic acid, 2,2-dimethyl-, anhydride (1538-75-6)

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Safety

Hazard Codes: C
Risk Statements: 34
Safety Statements: 26-36/37/39-45
RIDADR: UN 2920 8/PG 2
WGK Germany: 3
F: 9-13-21
TSCA: Yes
HazardClass: 8
PackingGroup: II
HS Code: 29159000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 143502
Product name: Trimethylacetic anhydride
Purity: 99%
Packaging: 25g
Price: $59
Updated: 2024/03/01

Sigma-Aldrich

Product number: 143502
Product name: Trimethylacetic anhydride
Purity: 99%
Packaging: 100g
Price: $176
Updated: 2024/03/01

TCI Chemical

Product number: P1414
Product name: Pivalic Anhydride
Purity: >98.0%(GC)
Packaging: 25mL
Price: $59
Updated: 2024/03/01

TCI Chemical

Product number: P1414
Product name: Pivalic Anhydride
Purity: >98.0%(GC)
Packaging: 250mL
Price: $295
Updated: 2024/03/01

Alfa Aesar

Product number: B22983
Product name: Trimethylacetic anhydride, 99%
Packaging: 25g
Price: $62.1
Updated: 2024/03/01

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Trimethylacetic anhydride Chemical Properties,Usage,Production

Description

Trimethylacetic anhydride is a pivalic acid derivative that is used in organic synthesis. The compound's reaction mechanism is believed to be the formation of an alkanoic acid, which reacts with a hydroxyl group to form an anhydride. Trimethyl acetic anhydride has been shown to have pharmacokinetic properties and can be used as a nonsteroidal anti-inflammatory drug. This compound has also been found to have a matrix effect on crystalline cellulose and is capable of forming nitrogen-containing carboxylic acids.

Chemical Properties

clear colourless liquid

Uses

A metabolite of a double prodrug (6-dGCV-DPiv

Uses

Trimethylacetic anhydride was used:

in solid-phase oligonucleotide synthesis
in kinetic resolution of racemic 2-hydroxy-γ-butyrolactones with diphenylacetic acid
as acylation and esterification reagent for anilines
as acylation and esterification reagent for phenols

Flammability and Explosibility

Not classified

Trimethylacetic anhydride Preparation Products And Raw materials

Raw materials

Preparation Products

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Trimethylacetic anhydride Suppliers

Americas 1 Belgium 1 Canada 1 China 195 Europe 1 France 1 Germany 4 India 8 Japan 3 Slovakia 1 South Korea 2 Switzerland 5 United Kingdom 5 United States 24 Global 252

Handan Huajun Chemicals Co., Ltd.

Tel: 0310-8166583 13303008150
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Email: 884971191@qq.com
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Creasyn Finechem(Tianjin) Co., Ltd.

Tel: 022-83946278 13820503911
Fax: 022-83945176
Email: sales@creasyn.com
Country: China
ProdList: 982
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J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

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ShangHai DEMO Chemical Co.,Ltd

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Beijing dtftchem Technology Co., Ltd.

Tel: 010-60275820 13031183356
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ProdList: 1390
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Energy Chemical

Tel: 021-021-58432009 400-005-6266
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Email: sales8178@energy-chemical.com
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Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13552068683
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Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9513
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View Lastest Price from Trimethylacetic anhydride manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Trimethylacetic Anhydride 1538-75-6
Price: US $180.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-06-05

Handan Huajun chemicals Co.,Ltd

Product: Pivalic anhydride 1538-75-6
Price: US $13.00/kg
Min. Order: 1kg
Purity: 99.0%
Supply Ability: 1000MT
Release date: 2024-01-24

airuikechemical co., ltd.

Product: trimethylacetic anhydride 1538-75-6
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 20 tons
Release date: 2024-07-12

1538-75-6, Trimethylacetic anhydrideRelated Search:

Iodomethyl pivalate Pivalic acid silver pivalate zinc pivalate 4-Dimethylaminopyridine PotassiuM triMethylacetate, 95% Pivaldehyde Ethyl trimethylacetate DIISOBUTYL ETHER Isobutyl propionate Isobutyl isobutyrate ISOBUTYRIC ACID N-PROPYL ESTER VALERIC ANHYDRIDE Propionic anhydride Methyl trimethylacetate Isobutyl acetate Isobutyl formate TRIMETHYLACETIC ANHYDRIDE

BIS(TRIMETHYLACETIC) ANHYDRIDE

2,2-DIMETHYLPROPIONIC ACID ANHYDRIDE

2,2-DIMETHYLPROPIONIC ANHYDRIDE

2,2-Dimethylpropionic anhydride, Pivalic anhydride

Bis(2,2-dimethylpropionic acid)anhydride

Bis(2,2-dimethylpropionic)anhydride

Bis(pivalic acid)anhydride

Bis(pivalic)anhydride

Dipivalic anhydride

Pivalic acid anhydride

Trimethylacetic anhydride,99%

Pivalic anydride

Propanoic acid, 2,2-dimethyl-, anhydride

Propanoicacid,2,2-dimethyl-,anhydride

2,2-dimethylpropanoyl 2,2-dimethylpropanoate

Trimethylacetic anhydride,2,2-Dimethylpropionic anhydride, Pivalic anhydride

Trimethylacetic anhy

TriMethylacetic anhydride, 99% 50ML

2,2-Dimethylpropionic Anhydride Trimethylacetic Anhydride

PIVALIC ANHYDRIDE FOR SYNTHESIS

Propanoic acid,2,2-dimethyl-, 1,1'-anhydride

TriMethylacetic anhydride 99%

Pivalic anhydride, >=98.0% (GC)

TRIMETHYLACETIC ACID ANHYDRIDE

TRIMETHYLACETIC ANHYDRIDE

1,1-Dimethylpropanoic anhydride

2,2-dimethyl-propanoicacianhydride

2,2-Dimethylpropanoicanhydride

PIVALIC ANHYDRIDE

PivalicAnhydride&gt

Adefovir Dipivoxil Impurity 15 (Pivalic Anhydride)

Adefovir Impurity 36

Trimethylacetic Anhydride1538-75-6

Adefovir Dipivoxyl Impurity 18

TIANFU-CHEM -TRIMETHYLACETIC ANHYDRIDE

Pivalic anhydride (7CI, 8CI)

Pivolic Anhydride

Pivalic anhydride,98%

Cevelestat sodium impurity B-3 (valeanhydride)

1538-75-6

C10H18O3

CH33CCO2O

Carbonyl Compounds

Carboxylic Acid Anhydrides

Building Blocks

Organic Building Blocks

Aliphatics, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals

Aliphatics

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals