ChemicalBook > CAS DataBase List > Trimethylacetic anhydride

Trimethylacetic anhydride

Product Name
Trimethylacetic anhydride
CAS No.
1538-75-6
Chemical Name
Trimethylacetic anhydride
Synonyms
PIVALIC ANHYDRIDE;Bis(2,2-dimethylpropionic)anhydride;Pivalic anydride;Bis(pivalic)anhydride;Pivalic acid anhydride;2,2-Dimethylpropanoicanhydride;2,2-dimethylpropanoyl 2,2-dimethylpropanoate;Pivolic Anhydride;Dipivalic anhydride;PivalicAnhydride>
CBNumber
CB9470666
Molecular Formula
C10H18O3
Formula Weight
186.25
MOL File
1538-75-6.mol
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Trimethylacetic anhydride Property

Boiling point:
193 °C(lit.)
Density 
0.918 g/mL at 25 °C(lit.)
vapor pressure 
62.1Pa at 25℃
refractive index 
n20/D 1.409(lit.)
Flash point:
135 °F
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Miscible with acetonitrile.
form 
Liquid
color 
Clear colorless
Sensitive 
Moisture Sensitive
BRN 
386552
InChI
InChI=1S/C10H18O3/c1-9(2,3)7(11)13-8(12)10(4,5)6/h1-6H3
InChIKey
PGZVFRAEAAXREB-UHFFFAOYSA-N
SMILES
C(C)(C)(C)C(=O)OC(=O)C(C)(C)C
LogP
2.15
CAS DataBase Reference
1538-75-6(CAS DataBase Reference)
EPA Substance Registry System
Propanoic acid, 2,2-dimethyl-, anhydride (1538-75-6)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 2920 8/PG 2
WGK Germany 
3
F 
9-13-21
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29159000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
143502
Product name
Trimethylacetic anhydride
Purity
99%
Packaging
25g
Price
$59
Updated
2024/03/01
Sigma-Aldrich
Product number
143502
Product name
Trimethylacetic anhydride
Purity
99%
Packaging
100g
Price
$176
Updated
2024/03/01
TCI Chemical
Product number
P1414
Product name
Pivalic Anhydride
Purity
>98.0%(GC)
Packaging
25mL
Price
$59
Updated
2024/03/01
TCI Chemical
Product number
P1414
Product name
Pivalic Anhydride
Purity
>98.0%(GC)
Packaging
250mL
Price
$295
Updated
2024/03/01
Alfa Aesar
Product number
B22983
Product name
Trimethylacetic anhydride, 99%
Packaging
25g
Price
$62.1
Updated
2024/03/01
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Trimethylacetic anhydride Chemical Properties,Usage,Production

Description

Trimethylacetic anhydride is a pivalic acid derivative that is used in organic synthesis. The compound's reaction mechanism is believed to be the formation of an alkanoic acid, which reacts with a hydroxyl group to form an anhydride. Trimethyl acetic anhydride has been shown to have pharmacokinetic properties and can be used as a nonsteroidal anti-inflammatory drug. This compound has also been found to have a matrix effect on crystalline cellulose and is capable of forming nitrogen-containing carboxylic acids.

Chemical Properties

clear colourless liquid

Uses

A metabolite of a double prodrug (6-dGCV-DPiv

Uses

Trimethylacetic anhydride was used:

  • in solid-phase oligonucleotide synthesis
  • in kinetic resolution of racemic 2-hydroxy-γ-butyrolactones with diphenylacetic acid
  • as acylation and esterification reagent for anilines
  • as acylation and esterification reagent for phenols

Flammability and Explosibility

Not classified

Trimethylacetic anhydride Preparation Products And Raw materials

Raw materials

Preparation Products

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Trimethylacetic anhydride Suppliers

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View Lastest Price from Trimethylacetic anhydride manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
TRIMETHYLACETIC ANHYDRIDE 1538-75-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-09-01
Henan Fengda Chemical Co., Ltd
Product
TRIMETHYLACETIC ANHYDRIDE 1538-75-6
Price
US $50.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-22
Handan Huajun chemicals Co.,Ltd
Product
Pivalic anhydride 1538-75-6
Price
US $13.00/kg
Min. Order
1kg
Purity
99.0%
Supply Ability
1000MT
Release date
2024-01-24

1538-75-6, Trimethylacetic anhydrideRelated Search:

Iodomethyl pivalate Pivalic acid silver pivalate zinc pivalate 4-Dimethylaminopyridine PotassiuM triMethylacetate, 95% Pivaldehyde Ethyl trimethylacetate DIISOBUTYL ETHER Isobutyl propionate Isobutyl isobutyrate ISOBUTYRIC ACID N-PROPYL ESTER VALERIC ANHYDRIDE Propionic anhydride Methyl trimethylacetate Isobutyl acetate Isobutyl formate TRIMETHYLACETIC ANHYDRIDE

  • BIS(TRIMETHYLACETIC) ANHYDRIDE
  • 2,2-DIMETHYLPROPIONIC ACID ANHYDRIDE
  • 2,2-DIMETHYLPROPIONIC ANHYDRIDE
  • 2,2-Dimethylpropionic anhydride, Pivalic anhydride
  • Bis(2,2-dimethylpropionic acid)anhydride
  • Bis(2,2-dimethylpropionic)anhydride
  • Bis(pivalic acid)anhydride
  • Bis(pivalic)anhydride
  • Dipivalic anhydride
  • Pivalic acid anhydride
  • Trimethylacetic anhydride,99%
  • Pivalic anydride
  • Propanoic acid, 2,2-dimethyl-, anhydride
  • Propanoicacid,2,2-dimethyl-,anhydride
  • 2,2-dimethylpropanoyl 2,2-dimethylpropanoate
  • Trimethylacetic anhydride,2,2-Dimethylpropionic anhydride, Pivalic anhydride
  • Trimethylacetic anhy
  • TriMethylacetic anhydride, 99% 50ML
  • 2,2-Dimethylpropionic Anhydride Trimethylacetic Anhydride
  • PIVALIC ANHYDRIDE FOR SYNTHESIS
  • Propanoic acid,2,2-dimethyl-, 1,1'-anhydride
  • TriMethylacetic anhydride 99%
  • Pivalic anhydride, >=98.0% (GC)
  • TRIMETHYLACETIC ACID ANHYDRIDE
  • TRIMETHYLACETIC ANHYDRIDE
  • 1,1-Dimethylpropanoic anhydride
  • 2,2-dimethyl-propanoicacianhydride
  • 2,2-Dimethylpropanoicanhydride
  • PIVALIC ANHYDRIDE
  • PivalicAnhydride&gt
  • Adefovir Dipivoxil Impurity 15 (Pivalic Anhydride)
  • Adefovir Impurity 36
  • Trimethylacetic Anhydride1538-75-6
  • Adefovir Dipivoxyl Impurity 18
  • TIANFU-CHEM -TRIMETHYLACETIC ANHYDRIDE
  • Pivalic anhydride (7CI, 8CI)
  • Pivolic Anhydride
  • Pivalic anhydride,98%
  • 1538-75-6
  • C10H18O3
  • CH33CCO2O
  • Carbonyl Compounds
  • Carboxylic Acid Anhydrides
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  • Organic Building Blocks
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  • Aliphatics
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