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ChemicalBook > CAS DataBase List > 4-Amino-3-fluorophenol

4-Amino-3-fluorophenol

Uses
Product Name
4-Amino-3-fluorophenol
CAS No.
399-95-1
Chemical Name
4-Amino-3-fluorophenol
Synonyms
4-Amino-3-fluorphenol;4-Amino-3-fL;4-AMino-3-fluo;BUTTPARK 33\04-79;Aminofluorophenol3;IFLAB-BB F2108-0045;4-Amino-3-fluorophen;3-FLUORO-4-AMINOPHENOL;4-AMINO-3-FLUOROPHENOL;2-FLUORO-4-YDROXYANILINE
CBNumber
CB7853597
Molecular Formula
C6H6FNO
Formula Weight
127.12
MOL File
399-95-1.mol
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4-Amino-3-fluorophenol Property

Melting point:
135-137°C
Boiling point:
270.4±25.0 °C(Predicted)
Density 
1.347±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
soluble in Methanol
pka
9.23±0.18(Predicted)
form 
powder to crystal
color 
Light yellow to Brown
InChI
InChI=1S/C6H6FNO/c7-5-3-4(9)1-2-6(5)8/h1-3,9H,8H2
InChIKey
MNPLTKHJEAFOCA-UHFFFAOYSA-N
SMILES
C1(O)=CC=C(N)C(F)=C1
CAS DataBase Reference
399-95-1(CAS DataBase Reference)
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Safety

Hazard Codes 
T,Xi,N
Risk Statements 
22-43-45-51/53
Safety Statements 
45-53-61
RIDADR 
3077
Hazard Note 
Toxic
HazardClass 
9
PackingGroup 
III
HS Code 
29214990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H350May cause cancer

H401Toxic to aquatic life

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2164
Product name
4-Amino-3-fluorophenol
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$71
Updated
2025/07/31
TCI Chemical
Product number
A2164
Product name
4-Amino-3-fluorophenol
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$295
Updated
2025/07/31
TRC
Product number
A609595
Product name
4-Amino-3-fluorophenol
Packaging
1g
Price
$95
Updated
2021/12/16
TRC
Product number
A609595
Product name
4-Amino-3-fluorophenol
Packaging
5g
Price
$245
Updated
2021/12/16
AK Scientific
Product number
J90717
Product name
3-Fluoro-4-aminophenol
Packaging
5g
Price
$14
Updated
2021/12/16
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4-Amino-3-fluorophenol Chemical Properties,Usage,Production

Uses

4-Amino-3-fluorophenol is a compound that can be used in organic synthesis.

Description

4-amino-3-fluorophenol, a light yellow to brown power, is the raw material of a kind of application medicine, a pesticidal active substance very widely, is a fluorinated insecticide, Phenoxymethyl acetate esters, and benzo pyrrole ketone herbicide, the intermediate of antibacterial and hair dye, etc. Fluoro substituents in the 4-amino-3-fluorophenol molecule increase the lipophile of the whole molecule greatly, thus adding to the membrane permeability of this molecule so that it is suitable as the active component intermediate of some medicines.

Chemical Properties

Dark Brown Solid

Synthesis

Using p-nitrophenol as raw material, after catalytic hydrogenation, a sulfonation reaction is performed first, and then a fluorine substitution reaction is performed to substitute the fluorine at the 3-position. Afterwards, a desulfonation reaction was carried out, and the target product 4-Amino-3-fluorophenol was obtained through extraction.

References

[1] Patent: US2005/277652, 2005, A1. Location in patent: Page/Page column 72-73
[2] Patent: WO2006/124118, 2006, A1. Location in patent: Page/Page column 74
[3] Patent: WO2005/9961, 2005, A2. Location in patent: Page/Page column 46
[4] Patent: WO2008/89388, 2008, A2. Location in patent: Page/Page column 16
[5] Patent: WO2008/89389, 2008, A2. Location in patent: Page/Page column 13

4-Amino-3-fluorophenol Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Amino-3-fluorophenol Suppliers

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View Lastest Price from 4-Amino-3-fluorophenol manufacturers

Jinan Ruitong Biotech Co., Ltd.
Product
4-Amino-3-fluorophenol 399-95-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1
Release date
2025-08-28
Shaanxi Dideu New Materials Co. Ltd
Product
4-Amino-3-fluorophenol 399-95-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
10000KGS
Release date
2025-05-07
Handan City Zechi trading Co., LTD
Product
4-amino-3-fluorophenol 399-95-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99
Supply Ability
10000
Release date
2025-03-22

399-95-1, 4-Amino-3-fluorophenolRelated Search:


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