phanquone
Uses- Product Name
- phanquone
- CAS No.
- 84-12-8
- Chemical Name
- phanquone
- Synonyms
- C-11925;entobex;enthohex;Entronon;phanquone;Ciba 11925;phanquinone;phanquone USP/EP/BP;4,7-phenanthroline-5,6-dione;4,7-phenanthroline-5,6-quinone
- CBNumber
- CB7875744
- Molecular Formula
- C12H6N2O2
- Formula Weight
- 210.19
- MOL File
- 84-12-8.mol
phanquone Property
- Melting point:
- 295° (dec)
- Boiling point:
- 349.71°C (rough estimate)
- Density
- 1.2785 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- Storage temp. 2-8°C
- pka
- -0.30±0.20(Predicted)
- form
- Solid
- color
- Crystals from methanol
- InChI
- InChI=1S/C12H6N2O2/c15-11-9-7(3-1-5-13-9)8-4-2-6-14-10(8)12(11)16/h1-6H
- InChIKey
- VLPADTBFADIFKG-UHFFFAOYSA-N
- SMILES
- C1C2=C(C(=O)C(=O)C3=C2C=CC=N3)N=CC=1
Safety
- Toxicity
- LD50 orl-rat: 5 mg/kg ANTCAO 8,297,58 orl-mus LD50:4 mg/kg ANTCAO 8,297,58
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CHM0995598
- Product name
- 4,7-PHENANTHROLINE-5,6-DIONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.15
- Updated
- 2021/12/16
- Product number
- BBC/602
- Product name
- 4,7-phenanthroline-5,6-dione
- Packaging
- 1g
- Price
- $171
- Updated
- 2021/12/16
- Product number
- BBC/602
- Product name
- 4,7-phenanthroline-5,6-dione
- Packaging
- 5g
- Price
- $355
- Updated
- 2021/12/16
- Product number
- CD11048382
- Product name
- 4,7-Phenanthroline-5,6-dione
- Purity
- 97%
- Packaging
- 1g
- Price
- $416
- Updated
- 2021/12/16
phanquone Chemical Properties,Usage,Production
Uses
Phenylamidone drugs are mainly used to treat amoebic dysentery and bacillary dysentery. Most existing synthetic methods involve nitrification, reduction, and hydrolysis of o-acetamipridanisole to produce 2,5-diaminoanisole sulfate, which is then reacted with glycerol and concentrated sulfuric acid in the presence of iodine and potassium iodide under heating to cyclize and obtain 6-methoxy-4,7-diaphenanthrene, which is then further oxidized to obtain the finished product.
Chemical Properties
Orange-red crystalline powder. Melting point 295°C. Slightly soluble in water, insoluble in ethanol and chloroform. Odorless, slightly bitter.
Originator
Phanquinone ,Yick-Vic Chemicals and
Definition
ChEBI: An orthoquinone that is the 5,6-diketo derivative of 4,7-phenanthroline.
Manufacturing Process
2 parts of 6-methoxy-4:7-phenanthroline are mixed with 10 parts by volume of concentrated sulfuric acid and while cooling with a mixture of ice and sodium chloride, with 6 parts by volume of fuming nitric acid (density = 1.51), and the whole is heated for 2 h at 120°C. The reaction solution is poured on to ice, its pH value is adjusted to 7 by means of a 10 N solution of caustic soda, after standing for 2 h the whole is filtered with suction to remove the precipitate which separates, and the latter is washed with hot water. After recrystallising the product from methyl alcohol and drying it at 100°C under 0.1 mm pressure, there are obtained 1.8 parts (i.e. 90 % of the calculated yield) of 4:7-phenanthroline-5:6-quinone in the form of pale yellow crystals melting at 295°C.
Therapeutic Function
Antiamebic
Safety Profile
Poison by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Purification Methods
The dione crystallises from MeOH. The mono-oxime forms yellow crystals from MeOH with m 250o(dec), the di-oxime forms yellow crystals from MeOH with m 300o(dec) and the mono-semihydrazone forms yellow crystals from MeOH with m 195o(dec). [Druey & Schmidt Helv Chim Acta 33 1080 1950, Beilstein 24 III/IV 1741.]
phanquone Preparation Products And Raw materials
Raw materials
Preparation Products
phanquone Suppliers
- Tel
- 086-18817515273 18817515273
- hm-huangmiao@163.com
- Country
- China
- ProdList
- 400
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 13921981169
- Fax
- -
- ftchem2016@163.com
- Country
- China
- ProdList
- 464
- Advantage
- 58
- Tel
- 0371-0371-55629727 13323845623
- Fax
- 037155629727
- 2885676761@qq.com
- Country
- China
- ProdList
- 10110
- Advantage
- 58
- Tel
- 0371-55900031 18137872243
- Fax
- QQ：2853979815
- 2853979815@qq.com
- Country
- China
- ProdList
- 9975
- Advantage
- 55
- Tel
- 021-2221346380 021-54220652 17701603001
- Fax
- QQ:2221346380
- bankpharma@163.com
- Country
- China
- ProdList
- 423
- Advantage
- 58
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 16027
- Advantage
- 58
- Tel
- 400-400-1332688 18019345275
- Fax
- 400-133-2688
- amy@rhawn.cn
- Country
- China
- ProdList
- 14948
- Advantage
- 58
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- +86-29-89586680 +86-15129568250
- 1026@dideu.com
- Country
- China
- ProdList
- 20284
- Advantage
- 58
View Lastest Price from phanquone manufacturers
- Product
- phanquone 84-12-8
- Price
- US $1000.00/KG
- Min. Order
- 25KG
- Purity
- 98%
- Supply Ability
- 10tons
- Release date
- 2018-07-26