alminoprofen
- Product Name
- alminoprofen
- CAS No.
- 39718-89-3
- Chemical Name
- alminoprofen
- Synonyms
- EB 382;Minalfen;Minalfene;alminoprofen;Alminoprofene;Alminoprofeno;rac AlMinoprofen;alminoprofen USP/EP/BP;ALMINOPROFEN(FORR&DONLY);Alminoprofene [inn-french]
- CBNumber
- CB7885929
- Molecular Formula
- C13H17NO2
- Formula Weight
- 219.28
- MOL File
- 39718-89-3.mol
alminoprofen Property
- Melting point:
- 107°
- Boiling point:
- 360.1°C (rough estimate)
- Density
- 1.0697 (rough estimate)
- refractive index
- 1.5100 (estimate)
- storage temp.
- -20°C Freezer
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.86±0.50(Predicted)
- color
- Light Brown
Safety
- Toxicity
- LD50 orally in mice: 2400 mg/kg (Dumaitre)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A575150
- Product name
- racAlminoprofen
- Packaging
- 1g
- Price
- $790
- Updated
- 2021/12/16
- Product number
- API0003395
- Product name
- ALMINOPROFEN
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1575
- Updated
- 2021/12/16
- Product number
- API0003395
- Product name
- ALMINOPROFEN
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $2255
- Updated
- 2021/12/16
- Product number
- CS-0009220
- Product name
- Alminoprofen
- Purity
- 99.35%
- Packaging
- 100mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- CS-0009220
- Product name
- Alminoprofen
- Purity
- 99.35%
- Packaging
- 250mg
- Price
- $450
- Updated
- 2021/12/16
alminoprofen Chemical Properties,Usage,Production
Description
Alminoprofen is an arylpropionic acid analgesic/antiinflammatory agent indicated for the short term management of dental, traumatic and postpartum pain.
Originator
Labs. Dr. E. Bouchara (France)
Uses
Alminoprofen is a nonsteroidal antiinflammatory drugs (NSAID) of the phenylpropionic acid class. Alminoprofen maybe a useful therapeutic option in the management of immune dysfunction in rheumatoid ar thritis.
Definition
ChEBI: A substituted aniline that is ibuprofen in which the isobutyl group is replaced by a (2-methylprop-2-en-1-yl)amino group. A non-steroidal anti-inflammatory drug, it is used for treatment of inflammatory and rheumatic disorders.
Manufacturing Process
Methyl 2-(p-aminophenyl)propionate:
Methyl 2-(p-nitrophenyl)acrylate (52 g) is hydrogenated in ethanol (500 ml) in
the presence of 5% palladium-over-charcoal, while maintaining the
temperature at +5°C. The theoretical amount of hydrogen is taken up within
one hour. After separation of the catalyst and concentration to dryness, the
resulting material gives methyl 2-(p-aminophenyl)proprionate which
crystallizes: MP: = 40°-43°C.
Methyl 2-(p-methallylaminophenyl)propionate hydrochloride:
A mixture of methyl 2-(p-aminophenyl)propionate (44.75 g), methallyl
chloride (34 g) and pyridine (30 ml) in isopropanol (400 ml) is boiled during
30 hours. The solvent is removed in vacuo and the residue is taken up into
water and ether. After separation, the organic phase is washed repeatedly
with water, after which it is dried and concentrated in vacuo. The resulting oil
is fractionally distilled in vacuo (0.1 mm Hg; 5 g of oil essentially consisting of
methyl 2-(p-aminophenyl)propionate are collected at 115°-120°C; 30 g of oil
consisting of a mixture of mono- (80%) and disubstituted (20%) amines is
collected at 128°-130°C. This oil is used to prepare the hydrochloride, which
is recrystallized from ethyl acetate, to give white crystals (22.7 g) melting at 115°C. Saponification in the cold methanolic hydroxide gives the desired 2-(4-
(methallylamino)phenyl)propionic acid (alminoprofen). MP: 120°C.
brand name
MINALFENE
Therapeutic Function
Analgesic, Antiinflammatory
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View Lastest Price from alminoprofen manufacturers
- Product
- alminoprofen 39718-89-3
- Price
- US $8.00/KG
- Min. Order
- 1g
- Purity
- Min98% HPLC/gc
- Supply Ability
- g/kg/ton
- Release date
- 2020-11-04
- Product
- alminoprofen 39718-89-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-06-15