N-Acetyl-L-thioproline

Product Name: N-Acetyl-L-thioproline
CAS No.: 54323-50-1
Chemical Name: N-Acetyl-L-thioproline
Synonyms: AC-L-Thz-OH;(R)-Aminofol;N-Ac-L-Pro-OH;N-Ac-L-Thz-OH;N-ACETYL-THIOPROLINE;N-Acetyl-L-thiaproline;N-Acetyl-L-thioproline;N-Acetyl-L-thioproline USP/EP/BP;3-Acetylthiazolidine-4-carboxylic acid;(R)-3-Acetylthiazolidine-4-carboxylicaci
CBNumber: CB7896439
Molecular Formula: C6H9NO3S
Formula Weight: 175.21
MOL File: 54323-50-1.mol

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N-Acetyl-L-thioproline Property

Melting point:: 143-145℃
Boiling point:: 439℃/760mm
Density: 1.46
storage temp.: 2-8°C
solubility: Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 3.27±0.20(Predicted)
color: White
InChI: InChI=1S/C6H9NO3S/c1-4(8)7-3-11-2-5(7)6(9)10/h5H,2-3H2,1H3,(H,9,10)/t5-/m0/s1
InChIKey: WXTBYSIPOKXCPM-YFKPBYRVSA-N
SMILES: S1C[C@@H](C(O)=O)N(C(C)=O)C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: A609645
Product name: (R)-Aminofol
Packaging: 250mg
Price: $45
Updated: 2021/12/16

TRC

Product number: A609645
Product name: (R)-Aminofol
Packaging: 5g
Price: $165
Updated: 2021/12/16

Ark Pharm

Product number: P000369003
Product name: (R)-3-Acetylthiazolidine-4-carboxylic acid
Purity: 95+%
Packaging: 25g
Price: $119
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17752
Product name: (R)-Aminofol
Packaging: 10mg
Price: $139.8
Updated: 2021/12/16

Activate Scientific

Product number: AS48637
Product name: (R)-3-Acetylthiazolidine-4-carboxylic acid
Purity: 95+% ee
Packaging: 25g
Price: $145
Updated: 2021/12/16

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N-Acetyl-L-thioproline Chemical Properties,Usage,Production

Chemical Properties

off-white to white powder

Uses

A cysteine derivative as potential antitumor agent

Synthesis

33898-90-7

34592-47-7

54323-50-1

GENERAL STEPS: L-thioproline (0.11 mol) and potassium chloride solution (100 mL) were added to the reaction vessel. The stirring speed was controlled at 150 rpm. the reaction mixture was heated to 85°C. A solution of 85% 2-thienylacetonitrile (50 mL) was slowly added dropwise with a controlled drip time of 40 min. The stirring rate was maintained and the reaction was continued for 120 minutes. Upon completion of the reaction, a reduced pressure distillation (2.3 kPa) was performed to separate the solid product. To the resulting solid, 90% p-xylene (80 mL) was added and heated to completely dissolve the solid. Decolorization was performed by adding decolorizing molecular sieves, maintaining the solution temperature at 15°C for 35 min. The solid impurities were removed by filtration and dehydrated using phosphorus pentoxide to give the final white N-acetyl-L-thioproline (1) (17.13 g, 89% yield).

References

[1] Patent: CN105541749, 2016, A. Location in patent: Paragraph 0014; 0015

N-Acetyl-L-thioproline Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Acetyl-L-thioproline Suppliers

Canada 1 China 134 India 2 United Kingdom 2 United States 5 Global 144

J & K SCIENTIFIC LTD.

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Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
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Chemsky (shanghai) International Co.,Ltd

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Chembon Pharmaceutical Co., Ltd.

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Beijing Isomersyn Technology CO;LTD

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Shandong Xiya Chemical Co., Ltd

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Syntechem Co.,Ltd

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China Langchem Inc.

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T&W GROUP

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View Lastest Price from N-Acetyl-L-thioproline manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: AC-L-Thz-OH 54323-50-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-01-15

Hebei Yanxi Chemical Co., Ltd.

Product: N-Acetyl-L-thioproline 54323-50-1
Price: US $50.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10000
Release date: 2023-10-20

Shandong Deshang Chemical Co., Ltd.

Product: N-Acetyl-L-thioproline 54323-50-1
Price: US $8.90-5.20/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 tons
Release date: 2024-07-12

54323-50-1, N-Acetyl-L-thioprolineRelated Search:

ACETYLTHIOCHOLINE IODIDE Ethyl 2-(Chlorosulfonyl)acetate Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) Acetyl chloride Thiazolidine-4-carboxylic acid L-PROLINE-(4-3H(N)) cis-4-Hydroxy-L-proline Acetylacetone 2-Methyl-4-isothiazolin-3-one N-ACETYL-L-TYROSINE ETHYL ESTER N-Acetyl-L-proline Acetyl coenzyme A sodium salt tributyl acetocitrate L(-)-Thiazolidine-4-carboxylic acid N-Acetyl-L-thioproline CARBOXYLIC ACID Acetyl-resveratrol

(R)-3-acetylthiazolidine-4-carboxylic acid

N-Acetyl-L-thiazolidiNe-4-Carboxylic acid

(4R)-3-Acetyl-4α-thiazolidinecarboxylic acid

3-Acetylthiazolidine-4-carboxylic acid

N-Acetyl-L-thioproline

(R)-Aminofol

(R)-3-Acetyl-1,3-thiazolidine-4-carboxylic acid

1-acetyl-3-sulfanylidene-2-pyrrolidinecarboxylic acid

N-ACETYL-THIOPROLINE

N-Acetyl-L-thiaproline

N-Ac-L-Pro-OH

N-Ac-L-Thz-OH

(R)-3-Acetylthiazolidine-4-carboxylic acid(N-Acetyl-L-Thioproline)

AC-L-Thz-OH

4-Thiazolidinecarboxylic acid, 3-acetyl-, (4R)-

(R)-3-Acetylthiazolidine-4-carboxylicaci

N-Acetyl-L-thioproline USP/EP/BP

TIANFU-CHEM 54323-50-1 N-Acetyl-L-thioproline

(4R)-3-Acetyl-1,3-thiazolidine-4-carboxylic acid

(4R)-3-Acetyl-4-thiazolidinecarboxylic acid

54323-50-1

Chiral Reagents

Heterocycles

Sulfur & Selenium Compounds